Trust: Reason,Routine, Reflexivity     

John B Kidd 《知识管理研究与实践》2006,4(3):254-255

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Clinico-Biochemical indexing of calcium urolithiasis on the basis of urinary citrate to calcium ratio and inhibition of mineralisation of urinary stone forming minerals by human urine     

T. V. R. K. Rao  Sofia Bano 《Indian journal of clinical biochemistry : IJCB》2003,18(1):52-60

Urinary citric acid and calcium levels have been estimated in the urine of 20 normal healthy persons as well as 12 urinary stone patients. Inhibition efficiency of these urine samples towards the mineralisation of urinary stone forming minerals, viz., calcium phosphate, oxalate or carbonate, has been studied in an experimental model. Statistical correlation of the above data has been made by computing the coefficient of determination and unexplained variance. Clinico-biochemical indexing of calcium urolithiasis risk factor has been attempted in the light of the data.  相似文献   

Is knowledge merely perception?     

Heiner Müller-Merbach 《知识管理研究与实践》2004,2(3):200-200

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Abstraction and Concept Formation     

Steven French 《Metascience》2007,16(3):539-542

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Optimal pruning for tree-structured vector quantization     

Jianhua Lin  James A. Storer  Martin Cohn 《Information processing & management》1992,28(6)

Tree-structured vector quantization (VQ) is a technique designed to represent a codebook that simplifies encoding as well as vector quantizer design. Most design algorithms for tree-structured VQ used in the past are based on heuristics that successively partition the input space. Recently, Chou, Lookabaugh and Gray proposed a tree-pruning heuristic in which a given initial tree is pruned backwards according to certain optimization criterion. We define the notion of an optimal pruned tree subject to a cost constraint and study the computational complexity of finding such an optimal tree for various cost functions. Under the assumption that all trees are equally probable, we show that, on the average, the number of pruned trees in a given tree is exponential in the number of leaves. Furthermore, we prove that finding an optimal pruned tree subject to constraints such as entropy or the expected-depth is NP-hard. However, we show that when the constraint is the number of leaves, the problem can be solved in polynomial time. We develop an algorithm to find the optimal pruned tree in O(nk) time, where n is the size of the initial tree and kis the constraint size.  相似文献   

Integrated MSS effects: An empirical health care investigation     

Guisseppi A. Forgionne  Rajiv Kohli 《Information processing & management》1995,31(6)

Since accurate decisions are required for effective management, much research has focused on information systems that support decision making. Recently, this research has engendered frameworks, such as the management support system (MSS), that are designed to provide comprehensive and integrated support for the decision making process. Few, if any, studies have empirically measured the effects of these frameworks on decision making. This article offers empirical evidence on MSS effectiveness. It overviews the decision making process, presents an MSS for supporting the process, and assesses the influences of the MSS on the process and outcomes of health care decision making. The paper also examines the implications of the analyses for information systems research and health care practice.  相似文献   

Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies     

K. A. Faseehuddin Shakir  Basavaraj Madhusudhan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):117-121

Rats fed with hypercholesterolemic diet showed a significant increase in serum total—cholesterol, liver homogenate total-cholesterol, HDL-cholesterol and changed LDL-cholesterol, and HDL/LDL ratio in comparison to control. Flaxseedchutney (FC) supplemented diet (15%, w/w) was found to be more effective in restoring lipid profile changes in rats fed with cholesterol, (1.0%). The activities of serum marker enzymes glutamate oxaloacetate transminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) were elevated significantly in carbon tetrachloride induced rats. Administration of flaxseedchutney (15%, w/w) resulted in depletion of serum marker enzymes and exhibited recoupment thus showing significant hepatoprotective effect. It was observed that flaxseedchutney supplemented diet could lower the serum cholesterol and as a potential source of antioxidants it could exert protection against hepatotoxic damage induced by carbon tetrachloride (CCl₄) in rats.  相似文献   

Maintaining the reversibility of foldings: Making the ethics (politics) of information technology visible   总被引：1，自引：0，他引：1  

Lucas D. Introna 《Ethics and Information Technology》2007,9(1):11-25

This paper will address the question of the morality of technology. I believe this is an important question for our contemporary society in which technology, especially information technology, is increasingly becoming the default mode of social ordering. I want to suggest that the conventional manner of conceptualising the morality of technology is inadequate – even dangerous. The conventional view of technology is that technology represents technical means to achieve social ends. Thus, the moral problem of technology, from this perspective, is the way in which the given technical means are applied to particular (good or bad) social ends. In opposition to this I want to suggest that the assumed separation, of this approach, between technical means and social ends are inappropriate. It only serves to hide the most important political and ethical dimensions of technology. I want to suggest that the morality of technology is much more embedded and implicit than such a view would suggest. In order to critique this approach I will draw on phenomenology and the more recent work of Bruno Latour. With these intellectual resources in mind I will propose disclosive ethics as a way to make the morality of technology visible. I will give a brief account of this approach and show how it might guide our␣understanding of the ethics and politics of technology by considering two examples of contemporary information technology: search engines and plagiarism detection systems.  相似文献   

Cardioprotective activity of synthetic guggulsterone (E and Z-isomers) in isoproterenol induced myocardial ischemia in rats: A comparative study     

Ramesh Chander  Farhan Rizvi  A. K Khanna  Ram Pratap 《Indian journal of clinical biochemistry : IJCB》2003,18(2):71-79

Guggulsterone, a mixture of cis (E) and trans (Z) isomers (7∶3 w/w) was synthesized from 16-DPA. The isomers were separated by column chromatography and evaluated for cardioprotective and antioxidant activities. Myocardial necrosis induced by isoproterenol in rats caused marked increase in serum creatine phosphokinase and glutamate pyruvate transaminase. Simultaneously in ischemic heart, phospholipase, xanthine oxidase and lipid peroxides were enhanced following depletion of glycogen, phospholipids and cholesterol. Treatment with guggulsterone and its both isomers at the dose of 50 mg/kg po., significantly protected cardiac damage as assessed by the reversal of blood and heart biochemical parameters in ischemic rats. The cardioprotective activity of guggulsterone and of both the isomers were compared with that of gemfibrozil at the same doses. Guggulsterone and both the isomers at tested concentrations (5–20mM) inhibited oxidative degradation of lipids in human low-density lipoprotein and rat liver microsomes induced by metal ionsin vitro. The drug counteracted against the generation of superoxide anions (O₂) and hydroxyl radicals (OH⁻) in non-enzymic test systems. It is suggested that cardioprotective and antioxidant activities of synthetic guggulsterone and guggulsterone obtained from gum resinCommiphora mukul that contains isomers E & Z in the ratio of 46∶54w/w are the same.  相似文献   

Serum super oxide dismutase (SOD), malondialdehyde (MDA) levels in urinary disorders     

J. Baxi  Kavita Sharma  Rajbala  Asha Mehta  A. K. Pendse  P. P. Singh 《Indian journal of clinical biochemistry : IJCB》1994,9(1):47-49

Evaluation of serum SOD and MDA level was done in 21 first episode renal stone formers, 9 recurrent stone formers, 20 patients with obstructive uropathy other than urolithiasis and 12 patients with urinary infection. Twenty-two healthy volunteers were taken as controls. The level of SOD in respective groups was 2.12±0.84, 2.78±0.85, 1.42±0.31, 1.98±0.70 and 2.32±0.62 units/ml and of MDA was 2.61±1.07, 2.69±1.15, 1.65±0.33, 1.33±0.34 and 1.55±0.48 n mol/ml respectively. The results indicate increased peroxidative stressin nephrolithiasis only. Since SOD level was normal in all groups, this increased peroxidative stress in nephrolithiasis should be due to factors other than this one.  相似文献