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Objective: A natural cyclic peptide previously isolated from Citrus medica was synthesized by coupling oftetrapep-tide units Boc-Leu-Pro-Trp-Leu-Ome and Boc-Ile-Ala-Ala-Gly-Ome after proper deprotection at carboxyl and amino terminals followed by cyclization of linear octapeptide segment.Methods: Solution phase technique was adopted for the synthesis of cyclooctapeptide--sarcodactylamide.Required tetrapeptide units were prepared by coupling of Boc-protected dipeptides viz.Boc-Leu-Pro-OH and Boc-Ile-Ala-OH with respective dipeptide methyl esters Trp-Leu-Ome and Ala-Gly-Ome.Cyclization of linear octapeptide unit was done by p-nitrophenyl ester method.The structure of synthesized cyclopolypeptide was elucidated by FTIR,1H NMR,13C NMR,FABMS spectral data and elemental analysis.The newly synthesized peptide was evaluated for dif-ferent pharmacological activities including antimicrobial,anthelmintic and cytotoxic activities.Results: Synthesis of sarcodac-tylamide was accomplished with >78% yield utilizing dicyclohexylcarbodiimide (DCC) as coupling agent.Newly synthesized peptide possessed potent cytotoxic activity against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines,in addition to moderate anthelmintic activity against earthworms Megascoplex konkanensis,Pontoscotex corethruses and Eudrilus sp.Moreover,cyclopolypeptide displayed good antimicrobial activity against pathogenic fungi Candida albicans and Gram-negative bacteria Pseudomonas aeruginosa,in comparison to standard drugs griseofulvin and ciprofloxacin.Conclusion: Solution phase technique employing DCC and triethylamine (TEA) as base proved to be effective for the synthesis of natural cyclooctapeptide.N-methyl morpholine (NMM) was found to be a better base for the cyclization of linear octapeptide unit in comparison to TEA and pyridine. 相似文献
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Since accurate decisions are required for effective management, much research has focused on information systems that support decision making. Recently, this research has engendered frameworks, such as the management support system (MSS), that are designed to provide comprehensive and integrated support for the decision making process. Few, if any, studies have empirically measured the effects of these frameworks on decision making. This article offers empirical evidence on MSS effectiveness. It overviews the decision making process, presents an MSS for supporting the process, and assesses the influences of the MSS on the process and outcomes of health care decision making. The paper also examines the implications of the analyses for information systems research and health care practice. 相似文献
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We present evidence on productivity improvement experienced by the research institutes of the Chinese Academy of Sciences (CAS) after its implementation of the Knowledge Innovation Program (KIP). Using a balanced panel of data on R&D inputs and outputs of 59 research institutes in CAS, we analyze the productivity, technological and efficiency changes from 1997 to 2005. We document that the CAS research institutes have a productivity growth of 12.5% from 1998 to 2005, which can be further decomposed into 8.8% attributed to technological progress and 3.3% to efficiency improvement. Results of regional analysis show that institutes in Beijing and Shanghai, performed better than institutes in other regions during the same period. 相似文献
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Teaching Multistep Equations with Virtual Manipulatives to Secondary Students with Learning Disabilities 
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下载免费PDF全文 Rajiv Satsangi Rachel Hammer Anya S. Evmenova 《Learning disabilities research & practice》2018,33(2):99-111
Students with learning disabilities often struggle with the academic demands presented in secondary mathematics curricula. To combat these students’ struggles, researchers have studied various pedagogical practices and classroom technologies for teaching standards covered in subjects such as algebra and geometry. However, as the role of computer‐ and tablet‐based technologies in education grows, some areas of study, such as the use of virtual manipulatives, lack exploration. This study sought to assess the benefits of virtual manipulatives to teach secondary students with a learning disability in mathematics how to solve multistep algebraic equations. A multiple baseline design across three participants demonstrated a functional relation between the use of a virtual manipulative balance and teaching students to acquire, maintain, and generalize the skill of solving multistep algebraic equations. Results provide new evidence demonstrating virtual manipulatives as a beneficial age‐appropriate technology to teach higher order mathematical concepts to secondary students with a learning disability. 相似文献
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Measuring academic growth, or change in aptitude, relies on longitudinal data collected across multiple measurements. The National Educational Longitudinal Study (NELS:88) is among the earliest, large-scale, educational surveys tracking students’ performance on cognitive batteries over 3 years. Notable features of the NELS:88 data set, and of almost all repeated measures educational assessments, are (a) the outcome variables are binary or at least categorical in nature; and (b) a set of different items is given at each measurement occasion with a few anchor items to fix the measurement scale. This study focuses on the challenges related to specifying and fitting a second-order longitudinal model for binary outcomes, within both the item response theory and structural equation modeling frameworks. The distinctions between and commonalities shared between these two frameworks are discussed. A real data analysis using the NELS:88 data set is presented for illustration purposes. 相似文献
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Wendy Kohli 《Educational theory》1998,48(4):511-519
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Tanu Kohli Bagwe 《Journal of Intercultural Communication Research》2020,49(4):346-371
ABSTRACT The importance of intercultural competence in today’s global economy is evident. Achieving intercultural competence, however, has no single formula. This study explored the variables impacting intercultural competence development. Through a systematic literature review, it identified 48 scholarly sources, 11 unique variables and two sub-variables impacting intercultural competence development. The impact of programme characteristics was found to be significant across the board, while the impact of demographic factors was harder to predict. The findings of this research inform scholars, educators and practitioners of the most effective ways to design intercultural experiences and help participants maximize their learning at home and abroad. 相似文献
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A Second-Order Conditionally Linear Mixed Effects Model With Observed and Latent Variable Covariates
A conditionally linear mixed effects model is an appropriate framework for investigating nonlinear change in a continuous latent variable that is repeatedly measured over time. The efficacy of the model is that it allows parameters that enter the specified nonlinear time-response function to be stochastic, whereas those parameters that enter in a nonlinear manner are common to all subjects. In this article we describe how a variant of the Michaelis-Menten (M-M) function can be fit within this modeling framework using Mplus 6.0. We demonstrate how observed and latent covariates can be incorporated to help explain individual differences in growth characteristics. Features of the model including an explication of key analytic decision points are illustrated using longitudinal reading data. To aid in making this class of models accessible, annotated Mplus code is provided. 相似文献