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11.
R. Kapoor D. B. Gundpatil B. L. Somani T. K. Saha S. Bandyopadhyay P. Misra 《Indian journal of clinical biochemistry : IJCB》2014,29(2):213-220
Cancer cells generally exhibit increased glycolysis for ATP generation (the Warburg effect). Compounds that inhibit glycolysis have potential applications in cancer treatment. dl-glyceraldehyde (DLG) and 2-Deoxyglucose (2-DG) have been proven effective in the inhibition of glucose metabolism. Ehrlich ascites carcinoma (EAC) cells were injected intraperitoneally (i.p) in 10–12 weeks old Swiss albino mice, weighing between 20 and 30 g. The anticancer activity of DLG and 2-DG were determined by tumor volume, tumor weight, viable and nonviable tumor cell count, average survival time, percentage increase in life span and tumor inhibition ratio. The blood samples were obtained for biochemical analysis after 9 days of treatment to study the effect on liver, kidney and haematological parameters. Histopathological examination of liver and kidney was also performed. One-way ANOVA test and Dunnett’s test were used for comparisons of parameters in study groups. Both DLG and 2-DG individually decreased the tumor weight, tumor volume, viable tumor cell count and significantly increased the life span of treated mice, however the combination was found to be better. The biochemical parameters of liver and kidney functions and haematological parameters were restored close to control group as compared with the EAC bearing mice. Histopathological examination of liver and kidney in EAC control group showed large areas of necrosis, congestion and mononuclear cell infiltration but such changes were not observed in liver and kidney sections observed after i.p injection of DLG and 2-DG for 9 days. Improvement was much better in the group where combination of these two drugs were used. 相似文献
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Serum Urea:Albumin Ratio as a Prognostic Marker in Critical Patients With Non-Chronic Kidney Disease
D. B. Gundpatil B. L. Somani T. K. Saha M. Banerjee 《Indian journal of clinical biochemistry : IJCB》2014,29(1):97-100
Routine laboratory investigations play an important role in estimating the risk of mortality in intensive care unit (ICU) patients. The significance of urea:albumin ratio (UAR) in predicting the stay and mortality of ICU patients is not known. It is a retrospective study of patients admitted to ICU (n = 412) with non-chronic kidney disease (non-CKD). Receiver-operating characteristics (ROC) analysis for predicting mortality was carried out to find area under curve (AUC) and threshold levels. Analysis of survival probability was carried out by Kaplan–Meier method and Log-rank test. The AUC to predict mortality were 0.695, 0.767 and 0.791 for serum albumin, urea and UAR, respectively. The threshold levels for albumin, urea and UAR were 2.8 g/dL, 53 mg/dL, and 23.44 mg/g, respectively. The highest odds ratio (OR) of 9.75 to predict mortality at threshold level was observed for UAR, while OR were 7.0 and 3.62 for serum urea and albumin, respectively. The serum urea above and albumin below threshold level were associated with increase in ICU stay of >3 days but the highest OR of 4.73 to predict stay of >3 days was observed for UAR. Kaplan–Meier survival analysis shows significant (p < 0.001) difference at the threshold value of UAR. Serum urea and albumin are found to be an independent predictor for the mortality and stay; however an increased UAR value is the best parameter in predicting mortality and stay in ICU patients with non-CKD illness. 相似文献
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Richard Axel and Linda B Buck received the Nobel Prize for their discoveries leading to an understanding of how odors are
perceived. A large family of receptors present in the nasal epithelium are activated by specific odorants and relay information
on the signal to the brain, allowing us to have the sense of smell. 相似文献
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Biswajit Saha 《Indian journal of clinical biochemistry : IJCB》2006,21(2):67-71
During routine screening, some otherwise healthy individuals who showed remarkably lower post prandial (at 2 hour) plasma
glucose without any symptom were subjected to extended glucose tolerance test and a few of them to extended post meal tolerance
test as well. It was observed that post prandial (at 2 hour) plasma glucose after glucose administration was significantly
lower than the fasting level (p<0.05−p<0.001). However, post prandial plasma glucose at 2 hour after their usual meal exhibited
a significantly higher level than the fasting and post glucose level (p<0.05−p<0.001). Glucose appears to be a stronger agent
than the more natural mixed meal in these individuals in causing post prandial lowering of plasma glucose. Hence, these individuals
are to be evaluated with their usual meals before considering further investigations. Like upper limit, there is the need
to have a consensus lower limit of reference interval of blood glucose level. 相似文献
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The investigation probed relationships among human‐figure drawing, field‐dependent‐independent cognitive style and self‐esteem of 10–15 year olds. It also attempted to predict human‐figure drawing scores of participants based on their field‐dependence‐independence and self‐esteem. Area, stratified and multi‐stage random sampling were used to select a sample of 600 10–15 year olds residing in Kolkata city, India. The sample comprised three age‐based strata: 10 and 11 year olds; 12 and 13 year olds; and 14 and 15 year olds. Each stratum comprised 100 girls and 100 boys. Participants’ actual age‐ranges were 10 years 1 month – 11 years 10 months (first stratum); 12 years 4 months – 13 years 10 months (second stratum); and 14 years 3 months – 15 years 9 months (third stratum). Goodenough‐Harris Drawing Test, Group Embedded Figures Test and Coopersmith Inventory were administered for assessing participants’ human‐figure drawing, field‐dependence‐independence and self‐esteem respectively. Results revealed significant positive relations among pertinent variables. Participants’ human‐figure drawing scores could be significantly predicted by their field‐dependence‐independence and self‐esteem. 相似文献
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Alumina nanoparticles （A1NP） were synthe- sized from aluminium nitrate using extracts of tea, coffee and triphala--a well known herbal plant as well as a non- toxic and eco--friendly green material. The synthesis was carried out taking 1：4 ratio of metal salt and these extracts under microwave irradiations at 540 W, which gave better yield of nanoparticles. Water was taken as solvent medium. The formations of A1NP were initially monitored by the colour changes occurring in the reaction mixture during the incubation period. As synthesized nanoparticles were characterized by scanning electron microscope （SEM）, UV-Visible （UV-Vis） spectroscopy and Fourier transform infrared spectroscopy （FTIR）. The A1NP were found to be spherical in shape in case of tea and coffee extracts with a size of 50-200 nm and to be oval shaped in case of triphala extract with an average size of 200-400 nm. The formation of A1NP with the microwave-assistance using these plant extracts has proved to be very faster than any other methods. In addition, excellent reproducibility of these nanoparticles, without the use of any additional capping agent or stabilizer will have great advantages in compari- son with microbial synthesis, avoiding all the tedious and hygienic complications. 相似文献
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Qualitative analysis of unknown organic compounds is an essential part of the core curriculum for BSc and MSc students in chemistry. The functional group detection is a significant component of qualitative analysis. The present work describes the reason for the failure of Mulliken-Barker test for nitro compounds having carboxylic acid functionality and suggests a possible remedy. 相似文献
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Asma Ahmed Banishree Saha Anand Patwardhan Shwetha Shivaprasad Dipankar Nandi 《Resonance》2009,14(6):610-621
Our immune system, by and large, does a fine job in protecting us from opportunistic and infectious microbes, potential carcinogens and allergens. It is therefore crucial to understand the organization of the immune network. This article focuses on some important features and key players involved in adaptive immune response. The first part of the article dealt with the humoral immune response mediated mainly by immunoglobulins produced by the B cells. The second part deals with T cells, the Major Histocompatibility Complex (MHC)-encoded molecules, and Recombination Activating Genes (RAG) responsible for generating diverse B-cell receptors (BCR) and T-cell receptors (TCR). With the advent of newer and smarter infectious agents, it is important to understand the working of the immune network as more research in this area may facilitate the development of better protective strategies. 相似文献