Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation     

Lu YH  Gao HJ  Li BJ  Zheng YM  Ye YH  Qian YL  Xu CM  Huang HF  Jin F 《Journal of Zhejiang University. Science. B》2012,13(1):1-10

To evaluate the effects of sperm with different parameters and sources on the outcomes of intracytoplasmic sperm injection (ICSI), 1972 ICSI cycles were analyzed retrospectively. Groups 1 to 5 were composed of cycles using ejaculated sperm and were grouped according to sperm quantity, quality, and morphology into normal (288 cycles), or mild (329 cycles), moderate (522 cycles), severe (332 cycles), and extremely severe (171 cycles) oligozoospermia and/or asthenozoospermia and/or teratozoospermia (OAT) groups. Group 6 was composed of 250 cycles using testicular or epididymal sperm, and Group 7 consisted of 80 cycles using frozen-thawed sperm. We found that fertilization rates were gradually reduced from Groups 1 to 6, and reached statistical difference in Groups 5 and 6 (P<0.05). The high-quality embryo rate was higher in Group 1 than in Groups 2, 3, 5, 6, and 7 (P<0.05). No statistical differences were observed in the rates of embryo cleavage, clinical pregnancy, miscarriage, live-birth, premature birth, low birth weight, weeks of premature birth, average birth weight, or sex ratio for all seven groups (P>0.05). A total of nine cases of malformation were observed, with a malformation rate of 1.25% (9/719). In conclusion, different sperm sources and parameters can affect ICSI outcomes before embryo implantation. A full assessment of offspring malformation will require further study using a larger sample size.  相似文献   

房产税的筹划及其会计核算     

张小庆 《商丘职业技术学院学报》2004,3(4):22-23

税收筹划，是指纳税人为充分享受税收权利、优化税收成本、回避涉税风险而进行的筹划活动和选择行为，客观上具有谋求合法的“实现税收最晚、承担税负最轻、适用税基最窄、享受税权最多、惩戒风险最小、税收成本最佳”目的。税收筹划的出现是税收进步的象征，是经济发展到一定阶段的必然现象，也是现代企业必修的功课。房产税是以房屋为征税对象，按房屋的计税余值或租金收入，向产权所有人征收的一种财产税。由于计税的依据不同，相应税率相差很大，因此，应当从加强会计核算的角度出发做好房产税的筹划。  相似文献   

科技期刊融合发展难题解决策略与复合型全媒体出版——以综合指导类期刊《今日科技》创新探索为例     

李祖平 《编辑学报》2017,29(3):284-286

根据《今日科技》10余年的创新转型实践,分析综合指导类科技期刊融合发展面临的难题,总结解决“广”与“专”、“浅”与“深”、“慢”与“快”3大难题的经验,实现全流程、整体性出版传播能力与价值持续提升的策略和路径:从“大杂烩”转型到“五专创新”,从“扩音器”提升到“决策咨询”,从纸质扩展到复合型、全媒体的出版传播.  相似文献   

Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF     

Qian YL  Ye YH  Xu CM  Jin F  Huang HF 《Journal of Zhejiang University. Science. B》2008,9(8):649-655

Objective:To evaluate the accuracy of a scoring system combining zygote and embryo morphology in predicting the outcome of in vitro fertilization(IVF)treatment.Methods:In a study group,117 consecutive IVF or intracytoplasmic sperm injection(ICSI) cycles with embryo transfer were carried out and 312 embryos were scored Using a combmed scoring system(CSS)of zygote and embryo morphology before transplantation.In a control group,a total of 420 IVF or ICSI cycles were carried out and 1176 embryos were scored using a cumulative embryo score(CES).The effects of the combined scoring system on the embryo implantation rate and pregnancy rate per cycle were analyzed.Results:Using the combined scoring system,the embryo implantation rate(27.6%)and the clinical pregnancy rate(48.7%)were significantly higher than those in the control group(20.8%and 38.6%,respectively).Also,the implantation rate of embryos scoring≥70 (38.5%:82 sacs/213 embryos)was significantly higher (P＜0.001)than that of embryos scoring＜70(4%:4 sacs/99 embryos).The pregnancy rate of patients with embryos scoring≥70 using the combined scoring system(66.7%)Was significantly higher(P＜0.001)than that of patients with embryos scoring≥20 using the cumulative embryo score(59.0%).Conclusion:The results suggest that selecting embryos with a high Score(≥70)using the combined scoring system could inerease the implantation rate and pregnancy rate,and that using a scoring system combining assessments of human zygotes and pre-implantation embryos might predict IVF outcomes more accurately than using a cumulafive embryo score.  相似文献   

Identification of embryonic chromosomal abnormality using FISH-based preimplantaion genetic diagnosis     

叶英辉  徐晨明  金帆  钱羽力 《浙江大学学报(A卷英文版)》2004,5(10):1249-1254

Objective: Embryonic chromosomal abnormality is one of the main reasons for in vitro fertilization (IVF)failure. This study aimed at evaluating the value of Fluorescence in-situ Hybridization (FISH)-based Preimplantation Genetic Diagnosis (PGD) in screening for embryonic chromosomal abnormality to increase the successful rate of IVF. Method:Ten couples, four with high risk of chromosomal abnormality and six infertile couples, underwent FISH-based PGD during IVF procedure. At day 3, one or two blastomeres were aspirated from each embryo. Biopsied blastomeres were examined using FISH analysis to screen out embryos with chromosomal abnormalities. At day 4, embryos without detectable chromosomal abnormality were transferred to the mother bodies as in regular IVF. Results: Among 54 embryos screened using FISH-based PGD, 30 embryos were detected to have chromosomal abnormalities. The 24 healthy embryos were implanted,resulting in four clinical pregnancies, two of which led to successful normal birth of two healthy babies; one to ongoing pregnancy during the writing of this article; and one to ectopic pregnancy. Conclusion: FISH-based PGD is an effective method for detecting embryonic chromosomal abnormality, which is one of the common causes of spontaneous miscarriages and chromosomally unbalanced offsprings.  相似文献   

浙江省内科科技史     

童钟杭 《科技通报》1997,13(1):59-63

概述了１８４０～１９９０年浙江省内科科技史．１８４３年美国教会在宁波开设诊所，是西医内科在省内的开端．之后，省内各地先后开设内科．２０世纪５０年代后，西医内科分化为传染病、神经、精神、心血管、消化、呼吸、内分泌、肾脏等专业．在科技领域，浙江省６０年代的血红蛋白病及冠心病研究，７０年代白血病、心电学及肺心病的研究，８０年代胃癌及糖尿病的研究都取得了令人注目的成就  相似文献   

Science Letters： Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography     

Zhang YZ  Zhou YC  Liu L  Zhu Y 《Journal of Zhejiang University. Science. B》2007,8(7):507-511

Simple, reliable and sensitive analytical methods to determine anticariogenic agents, preservatives, and artificial sweeteners contained in commercial gargles are necessary for evaluating their effectiveness, safety, and quality. An ion chromatography （IC） method has been described to analyze simultaneously eight anions including fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate （anticariogenic agents）, sorbate （a preservative）, and saccharin （an artificial sweetener） in gargles. In this IC system, we applied a mobile phased gradient elution with KOH, separation by IonPac AS18 columns, and suppressed conductivity detection. Optimized analytical conditions were further evaluated for accuracy. The relative standard deviations （RSDs） of the inter-day＇s retention time and peak area of all species were less than 0.938% and 8.731%, respectively, while RSDs of 5-day retention time and peak area were less than 1.265% and 8.934%, respectively. The correlation coefficients for targeted analytes ranged from 0.999 7 to 1.000 0. The spiked recoveries for the anions were 90%-102.5%. We concluded that the method can be applied for comprehensive evaluation of commercial gargles.  相似文献   

Anticoagulation therapy in intra-aortic balloon counterpulsation: Does IABP really need anti-coagulation?     

蒋晨阳  赵莉莉  王建安  单江  MOHAMMOD Balgaith 《浙江大学学报(A卷英文版)》2003,4(5):607-611

Objective: To investigate if intra-aortic balloon pump(IABP) is contraindicated without anticoagulation therapy. Methods: Some 153 IABP patients in the King Abdulaziz Cardiac Center(KSA) were randomly assigned into two groups. Anticoagulation group (Group A) consisted of 71 patients who were given heparin intravenously with target aPTT50–70 seconds. Non-anticoagulation group (Group B) consisted of 82 patients without intravenous heparin during balloon pumping. Hematological parameters including platelet count, D-dimer, Plasminogen activator inhibitor-1 (PAI-1) and fibrinogen degradation products (FDP) were checked respectively at the point of baseline, 24 hours, 48 hours and 24 hours post IABP counterpulsation. Clot deposits on balloon surface, vascular complications from IABP including bleeding and limb ischemia were recorded. Results: Platelet count and PAI-1 level decreased at 24 hours and 48 hours in both groups (P<0.05). D-dimer dimer and FDP level increased at 24 hours and 48 hours in both groups(P<0.05), but returned to the baseline level 24 hours post IABP removal (P>0.05). Three patients in Group A and 2 patients in Group B developed minor limb ischemia (P>0.05). No major limb ischemia in either group. Two patients in Group A suffered major bleeding and required blood transfusion or surgical intervention, whereas no patient had major bleeding in Group B. Eight patients had minor bleeding in Group A, but only 2 patients in Group B (P<0.05). No clot deposit developed on IABP surface in either group. Conclusion: IABP is safe without routine anticoagulation therapy. Selecting appropriate artery approach and early detection intervention are key methods for preventing complications.  相似文献   

查新信息资源的深度挖掘及定向服务探讨     

方飞  张帆 《中国科技信息》2012,(9):231-232

科技查新工作中能够获得丰富的信息资源,要使这些信息资源得到充分的利用,必须对其进行深度挖掘。通过对科技查新工作中形成的各类信息资源进行归类和分析,形成查新信息资源的一次文献、二次文献及三次文献,并提出了利用科技查新工作中获取的信息资源开展定向服务的设想。  相似文献   

SCIE收录2009年浙江省科技论文统计分析     

赵志娟 《科技管理研究》2012,32(8):38-39,44

通过对浙江省2009年度被SCIE收录的论文数量统计分析,了解浙江省的科研水平以及科研力量分布,为科研管理部门、科学研究人员以及企业提供定量参考依据.  相似文献