Alloimmunization to Red Cells and the Association of Alloantibodies Formation with Splenectomy Among Transfusion-Dependent β-Thalassemia Major/HbE Patients     

Suteenee Jansuwan  Orathai Tangvarasittichai  Surapon Tangvarasittichai 《Indian journal of clinical biochemistry : IJCB》2015,30(2):198-203

Severe hemolytic anemia in β-thalassemia major and β-thalassemias/HbE (β-TM) patients requires giving blood transfusions. Chronic blood transfusions lead to iron overload consequence with organs damage and risk of alloantibody-formation. This study evaluates the prevalence of red cell alloimmunization and estimates the risk of alloantibody-formation in chronic transfusion-dependent β-TM patients. This cross sectional study was conducted on 143 β-TM patients receiving regular transfusions. We tried to determine the frequency, types and factors influencing red cell alloimmunization in these transfusion-dependent β-TM patients. Median age of 25 (17.5 %) alloantibody-formation β-TM patients was 19.0 years (inter quartile 15.5–24.0 years). The alloantibodies were Anti-Rh (E) (13.1 %), Anti-Rh (D) (0.7 %). Thirty-four patients (23.8 %) of the sample had splenectomies of which 10 (29.4 %) had alloantibody-formation. The interval from first transfusion to antibody development varied from 1.5 to 14 years. Alloantibody-formation correlated with splenectomy and splenectomy correlated with number of transfusion (p < 0.005). In multiple logistic regression used to estimate the risk of alloantibodies formation with splenectomy; OR and 95 % CI were 2.88 (1.07–7.80), p = 0.037 after adjusting for other co-variates. The rate of red cell alloimmunization was 17.5 % and splenectomy associated with increased alloantibody-formation in these transfusion-dependent β-TM patients.  相似文献   

Detection of Bone Metastases in Breast Cancer (BC) Patients by Serum Tartrate-Resistant Acid Phosphatase 5b (TRACP 5b), a Bone Resorption Marker and Serum Alkaline Phosphatase (ALP), a Bone Formation Marker,in Lieu of Whole Body Skeletal Scintigraphy with Technetium99m MDP     

B. K. D. Sarvari  D. Sankara Mahadev  S. Rupa  S. A. Mastan 《Indian journal of clinical biochemistry : IJCB》2015,30(1):66-71

Bone metastases are a serious problem in patients with advanced cancer disease and their presence usually signifies serious morbidity prior to the patient’s death. In breast cancer patients the incidence of bone metastasis is observed to be very high at 70 %, as seen during post-mortem examination. Bone metastasis is difficult to diagnose, treat or follow clinically without radiological tools. This study was designed to evaluate the utility of a novel bone resorption marker–serum tartrate-resistant acid phosphatase 5b (TRACP5b) and the bone formation marker such as serum total alkaline phosphatase (ALP), in comparison with whole body skeletal scintigraphy with Technetium99m MDP for the diagnosis of bone metastases (BM) in breast cancer (BC) patients. This study is intended to help the clinician to diagnose bone metastasis without resorting to radiological tools, as they are not cost effective and carry the risk of radiation. Experimental design: Four groups of samples were analysed. 1st group consists 52 normal female (cancer free women), 2nd group consists 38 BC patients without bone metastasis, 3rd group consists 27 breast cancer patients with limited bone metastasis (3 or less than 3 skeletal lesions) and 4th group consists 35 breast cancer patients with extensive bone metastasis (4 or more than 4 skeletal lesions), conformed by whole body skeletal scintigraphy with Technetium99m MDP. One way ANOVA was used to compare serum TRACP5b and serum ALP among these groups. Both serum TRACP5b and serum ALP are not markedly elevated in limited bone metastasis but are strongly elevated in extensive bone metastasis (p < 0.0001). As seen in this study the biochemical bone resorption marker, serum TRACP5b, abnormally increased in extensive bone metastasis of breast cancer patients and can be used as a specific marker for bone metastasis in lieu of radiological tools.  相似文献   

论电子商务中的物流管理创新   总被引：13，自引：0，他引：13  

邱均平  宋恩梅 《中国软科学》2002,(4):107-110

网络时代电子商务的兴起给人类社会带来了巨大的变革,同时对传统商务方式和传统企业管理提出了严峻的挑战。在电子商务中,物流是商务流程的重要环节,但由于物流管理的严重滞后,在一定程度上造成了电子商务发展的困境。电子商务使现代物流管理面临着机遇和挑战,作为在工业社会业已存在的物流行业,其管理也必然要随之进行变革和创新。随着信息技术和供应链管理的兴起,电子商务物流管理已明显区别于传统的物流管理,成为一种建立在现代信息技术和先进管理思想之上的集成化的运作模式。在电子商务环境下,物流管理的创新需要通过物流管理技术化、信息化、柔性化和一体化等途径得以实现。而目前的电子商务企业自建物流体系、第三方物流配送以及第四方物流联盟等各具特色的物流管理模式都凸现出管理创新的主旨。  相似文献   

无线局域网技术特点及实现方案     

罗利民  樊爱京 《内江科技》2006,(1):101-101,88

无线网络越来越受欢迎．目前存在几种实现无线网络的技术。本文对各种无线网络技术的特点进行介绍，并且提出两个具体的实现方案。  相似文献   

EPC Class 1b规范研究     

邹应全  胥磊 《中国科技信息》2005,(11):30-31

本文阐述了射频识别技术(RFID)在UHF频段的EPC Class 1b协议及其主要内容、特点和发展前景，并分析了协议中具体技术，提出了解决多卡防碰撞解决方法。  相似文献   

无线局域网安全问题及解决方案   总被引：1，自引：0，他引：1  

沈海波 《培训与研究》2004,21(2):27-30

本研究了无线局域网常用的安全技术，分析了IEEE802．11b存在的主要安全缺陷，提出了一些解决无线安全问题的方案。  相似文献   

无线网络技术与校园网的组建   总被引：4，自引：1，他引：4  

雷朝铨 《宁德师专学报(自然科学版)》2003,15(2):116-119

介绍无线网络的基本概念,阐述其技术特点、网络标准、应用领域及所需设备,并给出一个组建校园网络的方案设想.  相似文献   

鸟类mtDNA中cytb基因及在系统进化研究中的应用   总被引：2，自引：0，他引：2  

陈艳荣  王继文 《黄山学院学报》2004,6(6):88-90

本文着重介绍了鸟类mtDNA中cytb基因的结构、功能、特点及其在鸟类系统进化研究领域中的主要应用。  相似文献   

浅谈无线网络在图书馆的应用     

姚斌 《闽西职业技术学院学报》2006,8(3):99-100

建设一个高质量的无线局域网是目前大多数图书馆发展所必要的,在技术上也是完全可行的。构建无线网络包括两个部分:布线施工和认证系统规划,须遵循可靠、先进、实用、灵活扩展、易用、安全等原则。  相似文献   

The Diagnosis of α-Thalassaemia: A Case of Hemoglobin H -α Deletion     

Bhat VS  Dewan KK  Krishnaswamy PR 《Indian journal of clinical biochemistry : IJCB》2010,25(4):435-440

We report a case of hemolytic anemia that was subsequently identified to be a case of α-thalassaemia harboring the common rightward 3.7 kb deletion/HbH. The diagnosis was based on sequential analyses using BioRad D10 HPLC, Alkaline gel electrophoresis, GPO α THAL-IC strips and the identification of the specific genetic lesion using an α Globin reverse dot blot hybridization assay. Supravital stain of RBCs helped in identifying classical HbH inclusions. In a background of a variable clinical presentation, lack of definitive hematological markers, and general under-diagnosis of α-thalassaemias we have used this case to highlight the features and sequence of techniques involved in identifying and characterizing an α-globin chain mutation, starting from a diffuse clinical history and presentation up to the identification of a specific genetic lesion involved.  相似文献