Clinical and biochemical characteristics of high-intensity functional training (HIFT) and overtraining syndrome: findings from the EROS study (The EROS-HIFT)     

Flavio A. Cadegiani  Claudio E. Kater  Matheus Gazola 《Journal of sports sciences》2019,37(11):1296-1307

The metabolic and hormonal consequences of high-intensity functional training regimens such as CrossFit® (CF) are unclear. Little is known about the triggers and clinical and biochemical features of CF-related overtraining syndrome (OTS). The EROS study compared endocrine and metabolic responses, and eating, social, psychological and body characteristics of OTS-affected (OTS) and healthy athletes (ATL), and non-physically active controls (NPAC). The current study is a post-hoc analysis of the CF subgroups of the EROS study, to evaluate specific characteristics of CF in ATL and OTS. Parameters were overall and pairwise compared among OTS-affected (CF-OTS) and healthy (CF-ATL) athletes that exclusively practiced CF, and NPAC. CF-ATL yielded earlier and enhanced cortisol, GH, and prolactin responses to an insulin tolerance test (ITT), increased neutrophils, lower lactate, increased testosterone, improved sleep quality, better psychological performance, increased measured-to-predicted basal metabolic rate (BMR) ratio and fat oxidation, and better hydration, when compared to NPAC. Conversely, more than 90% of the adaptive changes in CF were lost under OTS, including an attenuation of the hormonal responses to an ITT, increased estradiol, decreased testosterone, and decreased BMR and fat oxidation; the most remarkable trigger of OTS among “HIFT athletes” was the long-term low carbohydrate and calorie intake.  相似文献   

Intervención naturalista en la comunicación y el lenguaje en ámbito familiar: un estudio de cuatro casos     

《Infancia y Aprendizaje》2013,36(3):307-324

Resumen

En el estudio de casos presentado en este artículo se analizan cualitativamente las interacciones comunicativas y lingüísticas entre cuatro madres y sus hijos con síndrome de Down observadas en sus hogares durante siete meses. A lo largo de este tiempo se implementó un programa de intervención naturalista con las madres cuya finalidad era mejorar las interacciones con sus hijos, así como optimizar el desarrollo de la comunicación y el lenguaje de los niños. Las entrevistas de orientación con las madres constituyeron el instrument principal del programa de intervención. Para el análisis de las interacciones se utilizeó un instrumento de observación compuesto por tres bloques: 1) las estrategias de gestión de la comunicación y la conversación, 2) las estrategias de adaptación y ajuste del input y 3) las estrategias educativas. Los resultados indican que la intervención naturalista puede cambiar en sentido positivo la calidad de las interacciones diádicas entre las madres y sus hijos con síndrome de Down.  相似文献   

Visions for literacy: parents’ aspirations for reading in children with Down syndrome     

Leila Ricci  Anna Osipova 《British Journal of Special Education》2012,39(3):123-129

Although children with Down syndrome (DS) can learn to read, few studies have explored parental perspectives on the reading development of this group of children. This article, written by Leila Ricci and Anna Osipova, from California State University, explores visions and expectations regarding reading held by parents of children with Down syndrome in the US. Parents of 50 children with DS (aged three to 13 years) completed a survey about their children's interest in reading and responded to open‐ended questions inquiring about their views on their children's reading development. A majority of parents in this study described their children's positive attitude toward reading, stated their reading‐related goals for their children, defined their children's relative strengths in reading, and shared strategies used in the home to promote literacy in this population. Parents pay close attention to and have high expectations for their children's reading achievement, and thereby would benefit from partnerships with informed educators willing and capable of teaching reading to children with DS.  相似文献   

Children with Down Syndrome Sharing Past Personal Event Narratives with Their Teacher Aides: A Pilot Study     

Anne K. van Bysterveldt  Marleen F. Westerveld 《International Journal of Disability, Development & Education》2017,64(3):249-269

Personal narrative ability is crucial for social–emotional well-being and classroom participation. This study investigated the ability of 10 school-age participants with Down syndrome to share past personal experiences with their teacher aides in their school environment. To participate, children were required to speak in short sentences and be largely intelligible to unfamiliar listeners. Personal narratives were elicited using photo prompts, comprising a set of the child’s own photographs and a standard set of photographs and accompanying verbal prompts, utilising a clinical language sampling protocol. Personal narratives were analysed on quality, syntactic complexity, verbal fluency and intelligibility. Examiner behaviour was evaluated for measures of syntactic complexity, mean turn length in utterances and number of utterances. Results indicated significant difficulties in producing quality personal narratives in both photo conditions. Examiner behaviour was negatively correlated to the participants’ spoken language performance. Clinical implications are highlighted.  相似文献   

“Leaps of faith”: parents' and professionals' viewpoints on preparing adolescents on the autism spectrum for leaving school          下载免费PDF全文

Megan Hatfield  Marita Falkmer  Torbjorn Falkmer  Marina Ciccarelli 《Journal of Research in Special Educational Needs》2017,17(3):187-197

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A new mutation （1062 del 16） of iduronate-2-sulfatase gene from a Chinese patient with Hunter syndrome     

Guo YB  Pan JX  Meng YX 《Journal of Zhejiang University. Science. B》2007,8(8):566-569

Objective: To identify the mutations of iduronate-2-sulfatase (IDS) gene, to reveal its mutation features, and to establish a basis for genetic counseling and prenatal gene diagnosis of Hunter syndrome. Methods: Urine glycosaminoglycans (GAGs) assay, PCR and DNA sequencing were performed to detect mutation of IDS gene of the patient and his parents. Results: The result showed that the patient was: DS( ), HS( ), KS(-), CS(-), and that both of his parents were negative. A frame-shift deletion mutation (1062 del 16) was identified in exon 7 of the patient's IDS gene. His parents' genotypes were normal. Conclusion:The patient's mutation was not inherited by his parents but a novel one. The mutation probably altered the primary structure and tertiary structure of IDS enzyme protein remarkably and lowered the activity of IDS enzyme greatly. Therefore it is supposed to be the direct cause of the disorder.  相似文献   

Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris     

Qiao XZ  Yang YM  Xu ZR  Yang LA 《Journal of Zhejiang University. Science. B》2007,8(12):875-880

Objective To investigate the relationship between serum resistin level and acute coronary syndrome (ACS) or stable angina pectoris (SAP). Methods Sixty-five patients, with coronary artery disease, were enrolled and divided into three subgroupsacute myocardial infarction (AMI), unstable angina pectoris (UAP) and SAP, and 26 healthy people were recruited as controls in the cross-sectional study. Serum resistin levels were determined by ELISA (enzyme-linked immunosorbent assay), and WBC (white blood cell count), hsCRP (high sensitive C-reaction protein), CKmax (maximum ofcreatinkinase), CK-MBmax (maximum of isozyme of creatinkinase) and cTnImax (maximum oftroponin) were measured by standard laboratory methods. Results The serum resistin levels were 4 folds higher in AMI patients, 2.43 folds in UAP patients and 1.12 folds in SAP patients than in the healthy controls (P＜0.05). The resistin levels were also significantly different between AMI [(8.16±0.79) ng/ml], UAP [(5.59±0.75) ng/ml]and SAP [(3.45±0.56) ng/ml] groups (P＜0.01); WBC, hsCRP, CKmax, CK-MBmax and cTnImax were significantly increased in AMI patients over UAP and SAP patients. Spearman analysis showed that serum resistin levels were positively correlated with WBC (r=0.412, P=0.046), hsCRP (r=0.427, P=0.037), CKmax, CK-MBmax and cTnImax (r=0.731, 0.678, 0.656; P＜0.01). ConclusionSerum resistin levels increased with inflammatory factors and myocardial impairment. The results suggest that human resistin might play an important role in the pathogenesis of atherosclerosis and AMI as an inflammatory factor.  相似文献   

茶与人体健康：茶叶活性组分的生物医学效应和当前关注的若干问题   总被引：2，自引：0，他引：2  

Zong-mao CHEN  Zhi LIN 《Journal of Zhejiang University. Science. B》2015,(2)

饮茶有益于健康的观念在我国已沿传多个世纪,并在很大程度上为全世界所接受。本文简述了茶叶的药用历史以及从中国传播到世界各地的历史进程,重点对国内外关于饮茶预防癌症、代谢综合症、心血管疾病以及神经退行性疾病等人体重要疾病的最新研究成果进行了综述。在此基础上,针对当前在动物实验和人体流行病学调查结果上存在差异的原因,特别是对茶叶中儿茶素类化合物在人体组织中生物可利用度低的问题、高剂量绿茶提取物对人体可能存在毒性等安全性问题进行了讨论。此外,还介绍了近几年在提高儿茶素类化合物生物可利用度和对癌症的预防和治疗效果上的最新进展。  相似文献   

Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism     

S. Suresh  T. Vijayakumar 《Indian journal of clinical biochemistry : IJCB》2015,30(3):345-350

Functional ovarian hyperandrogenism (FOH) is a form of polycystic ovary syndrome (PCOS) characterized by elevated circulating levels of androgens derived from the ovary. Insulin resistance (IR) is the most common etiological factor in women with FOH. IR causes the generation of increased oxidative stress (OS) and diminished antioxidant status. OS is directly correlated with both IR and testosterone levels, which consequently contribute to endocrine and biochemical alterations in FOH women. In the current study, elevations in total testosterone, free testosterone and luteinizing hormone (LH) levels accompanied by a decrease in follicle stimulating hormone (FSH) level leading to higher LH:FSH ratio were the prominent endocrine changes observed in women with FOH. A significant increase in fasting blood levels of glucose and insulin, as well as an elevated IR were also seen in FOH women, as compared to their age matched controls. Women with FOH have higher pro-oxidant and lower anti-oxidant levels in blood than their age matched controls. In FOH women, elevations in LH:FSH ratio and OS are correlated more with hyperandrogenemia than with IR. Of the androgens, free rather than total testosterone has better positive correlations with elevated LH:FSH ratio and OS, and hence, the former is a better predictive marker for the development of biochemical PCOS in women with FOH.  相似文献   

加味柴芍六君颗粒加减治疗腹泻型肠易激综合征80例临床疗效观察     

黄剑声  赵晓芳  王伟 《大众科技》2015,(5)

目的:临床观察中药加味柴芍六君颗粒治疗腹泻型肠易激综合征(irritable bowel syndrome-diarrhea predomina nt,IBS-D)的临床疗效。方法:将80例IBS-D患者随机分为加味柴芍六君颗粒中药组和培菲康西药组,分别给予加味柴芍六君颗粒及口服培菲康治疗。疗程均为4周,疗程结束后随访3个月,观察疗效。结果:(1)治疗2、4周后、治疗结束后第1个月及第3个月随访时,结果两组的证候总积分改善明显优于治疗前,差异有统计学意义(p0.05);(2)治疗4周后,中药组总有效率为81.1%,西药组为70.4%,2组总体疗效差异无统计学意义(p=0.194);在单项症状方面排便次数和大便性状等改善情况中药组要优于西药,差异具有统计学意义(p0.05);(3)在第1、第3个月随访中药组证候积分改善优于西药组,差异具有统计学意义(p0.05)。结论:临床应用加味柴芍六君颗粒治疗IBS-D具有较好的临床疗效。  相似文献