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BackgroundDiabetes is a metabolic disorder caused by defects in insulin production and activity. During disease progression, changes in lipid peroxidation cause structural modifications via production of free radicals. Fangchinoline is a well-known alkaloid present in Stephaniae tetrandrine S. Moore, which has demonstrated antioxidant, anticancer, and anti-inflammatory activities.ResultsThe present study analyzed the anti-diabetic and antioxidant effects of fangchinoline in male rats with streptozotocin-induced diabetes. Rats were divided into the following groups: normal control, diabetic, diabetic + fangchinoline 100 mg/kg, diabetic + fangchinoline 200 mg/kg and diabetic + glibenclamide 600 µg/kg. The treatment was administered orally for 45 consecutive days. Lipid peroxidation was substantially increased by >50% in the serum, as well as the liver, kidney, and heart tissues of diabetic rats. However, fangchinoline supplementation significantly reduced lipid peroxidation to near normal levels. Reactive oxygen species levels were substantially increased by >500% in the serum, as well as the liver, kidney, and heart tissues of diabetic rats. Fangchinoline supplementation reduced reactive oxygen species to near normal levels. Fangchinoline supplementation significantly improved superoxide dismutase, glutathione peroxidase, catalase, and reduced glutathione levels in diabetic rats. Total hexoses, sialic acid, hexosamines, and fucose were increased in diabetic rats, whereas fangchinoline supplementation significantly reduced these total hexoses, sialic acid, hexosamines, and fucose to near normal levelsConclusionsSupplementation with fangchinoline led to significant attenuation of the levels of lipid peroxidation, ROS, and glycoprotein components such as total hexoses, hexosamines, sialic acid, and fucose, while improving antioxidant marker levels.How to cite: Xia J, Huang W, Zhou F. Effect of fangchinoline on oxidant status in male albino rats with streptozotocin-induced diabetes. Electron J Biotechnol 2021;53. https://doi.org/10.1016/j.ejbt.2021.07.005 相似文献
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Miriam Varkey R. Sundara Devi Shrinivas B. Rao 《Indian journal of clinical biochemistry : IJCB》1997,12(1):63-66
The levels of total sialic acid, lipid bound sialic acid and fucose were estimated in the sera of patients with benign and
malignant tumours of breast. An increase was noted in all the three parameters, with a more marked increase in malignancy,
when compared with benign and controls. Consequent to surgery, there was an elevation in the serum levels of the above parameters
than the values prior to surgery and a decline was noted two months after surgery although none of the values reached the
normal range. These results suggest a close association of the glycoproteins with the tumour burden and further signify their
role in early detection and staging of cancer breast. 相似文献
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C. R. Wilma Delphine Silvia D. M. Vasudevan K. Sudhakar Prabhu 《Indian journal of clinical biochemistry : IJCB》2001,16(1):113-115
The present study was conducted on thirty untreated oral cancer patients proved by clinical and histopathological evidence
and thirty healthy control subjects. The levels of glycoprotein-associated carbohydrates such as hexose, hexosamine, fucose
and sialic acid were found to be elevated significantly as compared to control subjects. There was a progressive rise in these
markers as the stages of oral cancer advanced. 相似文献
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