大学生专业创新能力培养与第二课堂建设     

曹广祥  姜媛媛  钟传青 《环球赛鸽科技》2014,(36)

高校教育工作者应注重对当代大学生创新能力的培养,提高其综合能力。教师需要尊重学生的思维方式和新想法、新创意,主动地去引导,鼓励学生的创新思维。本文探讨如何合理利用第二课堂,提高学生自主创新的积极性,为学生提供学习、交流、创新的机会和平台,同时拓展学生视“,激发大学生内在潜能,提高学生综合素质,满足现代社会对创新型人才的需求。  相似文献   

Complex coronary lesions and rotational atherectomy: one hospital’s experience     

Jun Jiang  Yong Sun  Mei-xiang Xiang  Liang Dong  Xian-bao Liu  Xin-yang Hu  Yan Feng  Jian-an Wang 《Journal of Zhejiang University. Science. B》2012,13(8):645-651

Objective

To evaluate the safety and effectiveness of rotational atherectomy followed by drug eluting stent (DES) implantation in patients with complex coronary lesions.

Methods

From August 2006 to August 2012, 253 consecutive patients with 289 lesions and who underwent rotational atherectomy in our center were enrolled in this study.

Results

The overall procedure success rate was 98% with the cost of two (0.8%) coronary perforations, three (1.2%) dissections, five (2.0%) slow flows or no flows, three (1.2%) peri-procedure myocardial infarctions, and two (0.8%) in hospital deaths. During follow-up (mean three years), one (0.4%) patient died, two (0.8%) patients had acute myocardial infarction, 14 (5.5%) had restenosis, and target lesion revascularization occurred in eight patients (3.2%).

Conclusions

Rotational atherectomy followed by DES implantation is a safe and effective technique for patients with complex coronary lesions, especially calcified and non-dilatable lesions.  相似文献   

丙泊酚复合瑞芬太尼靶控静脉麻醉与静吸复合麻醉的临床观察   总被引：1，自引：0，他引：1  

宋甲  宋玲  万辉勤 《宜春学院学报》2006,28(4):91-92

目的:比较丙泊酚复合瑞芬太尼靶控静脉麻醉与静吸复合麻醉的诱导和术后苏醒过程.方法:选腹腔镜胆囊切除术40例,ASA I—II级,15—66岁,随机分为静吸复合麻醉(C)组,丙泊酚瑞芬太尼靶控(R)组,每组20例,观察麻醉诱导,气管插管时的血压、心率,术毕停药后病人自主呼吸恢复时间,呼之睁眼时间,拔管时间,离开手术室时间,观察恶心、呕吐情况.结果:C组诱导时的收缩压低于R组,低血压者多于R组,插管反应发生率R组低于C组;二组病人术后自主呼吸恢复时间,呼之睁眼时间,拔管时间差异无显著性,恶心、呕吐发生率差异无显著性.结论:与静吸复合麻醉相比,异丙酚瑞芬太尼靶控输注麻醉诱导更平稳.  相似文献   

全英文药物设计的研究型教学改革     

梁建华  赵东旭  冯旭东  吕波 《教育教学论坛》2020,(18):213-215

药物设计是药物研发的核心课程,一直存在教学和研究实际脱离的状况。为了满足一流学科建设和研究型人才培养的需求,将构效关系和构性关系作为课程两大主题,通过案例式教学穿插知识点,了解真实研发管线。同时,发挥学生主观能动性,挖掘科研选题,分析文献进展,通过期末报告评价、同行论文发表以及申请基金等方式进行全方位学习效果评价。充分发挥研究型大学"双一流"建设的优势,改善学生的学习效果并加强科研能力培养。  相似文献   

Learning Analytics: Insights Into the Natural Learning Behavior of Our Students     

Bernd Becker 《Behavioral & Social Sciences Librarian》2013,32(1):63-67

The literature of gerontology may be found in the journals of many disciplines and in the popular press. Only journals published in the U.S. and devoted exclusively or in large part to the literature of social gerontology are described here. Journals intended primarily for the layman rather than for the professional worker are not included, even though they may contain some material of interest to the professional. All available bibliographic information is given, and special features of each journal are described. Newsletters of more than local significance are listed but not individually described.  相似文献   

PharmGuide: Your Guide to Free Online Drug Information     

Amy J. Chatfield  Jean L. Siebert  Jonathan Koffel 《Medical reference services quarterly》2013,32(2):163-171

PharmGuide <http://goo.gl/f14Me>is an annotated directory of high quality, freely available, online drug information resources intended for use by librarians, pharmacists, and the public. Given the plethora of drug information websites with varying levels of authoritativeness and accuracy, PharmGuide is intended to facilitate the search for resources by providing links to only those sources that have been critically appraised and that meet specific quality criteria. Methods used in developing the site, evidence of its utility based on usage statistics, and examples of its application in practice are presented within the context of the drug information landscape.  相似文献   

Impact of the excise tax on firm R&D and performance in the medical device industry: Evidence from the Affordable Care Act     

Daeyong Lee 《Research Policy》2018,47(5):854-871

This article examines how the excise tax affects firms’ R&D investment, performance, and market strategy in the US medical device industry. The Affordable Care Act imposed a 2.3% excise tax on medical devices beginning in January 2013, and thus this study compares the medical device firms with other high-tech firms before and after the tax incidence. Using COMPUSTAT data from 2006 to 2015, the author finds that the excise tax reduced R&D investment, sales revenue, gross margins, and earnings for medical device firms. In addition, the excise tax increased their global market sales intensity, global market diversification, and customer diversification in the US domestic market.  相似文献   

The NBER Orange Book Dataset: A user’s guide     

《Research Policy》2023,52(7):104791

This paper introduces a newly digitized, open-access version of the Food and Drug Administration’s “Orange Book”—a linkage between approved small-molecule drugs and the patents that protect them. The Orange Book also reports any applicable regulatory exclusivity that prevents competitive entry. We summarize the Orange Book’s coverage and discuss the opportunities and challenges associated with using these data for research. Empirical validations against various administrative datasets suggest that Orange Book records are, largely, complete and accurate. We conclude with a specific use case—calculating legal exclusivity periods for drugs—to highlight the types of choices that researchers must make when using this resource.  相似文献   

环氧合酶-2(COX-2)通过调控细胞上皮间质转化(EMT)促进卵巢癌细胞迁移及其耐药性     

Lin DENG  Ding-qing FENG  Bin LING 《Journal of Zhejiang University. Science. B》2020,21(4):315-326

目的:研究环氧合酶-2(COX-2)对卵巢癌细胞迁移和耐药性的影响及其机制。创新点:本研究发现COX-2对卵巢癌发生发展有一定的促进作用,可以通过上皮间质转化(EMT)途径促进卵巢癌细胞的迁移和顺铂(CDDP)耐药。其抑制剂塞来昔布(CXB)能起到协同抗癌的效果。方法:CCK-8检测CXB和CDDP对SKOV3和ES2细胞的毒性作用。划痕实验评估COX-2对卵巢癌细胞迁移的作用。蛋白质免疫印迹(western blot)和聚合酶链式反应(PCR)检测EMT相关基因和蛋白的表达水平。结论:COX-2可以通过EMT促进卵巢癌细胞迁移和CDDP耐药;CXB可以起到抑制作用,与CDDP协同抗癌。COX-2可以作为卵巢癌治疗的一个潜在靶点。  相似文献   

《药物合成反应》课程教学改革与探索     

孙淑萍 《教育教学论坛》2019,(17):116-117

本文根据《药物合成反应》课程特点,结合制药工程专业教学的实际情况,对教学内容和方法以及学生成绩评价方法进行了改革和探索。教学实践表明,该课程的教学改革提高了学生学习的主观能动性,加强了学生对理论知识的学习和实验能力的培养。  相似文献