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71.
王建军 《黄冈职业技术学院学报》2012,(4):88-90
目的观察沙丁胺醇和丙酸氟替卡松雾化吸入治疗慢性阻塞性肺病急性加重的疗效。方法将29例慢性阻塞性肺疾病急性加重的患者随机分成两组,对照组28例,常规给予抗生素及相应对照治疗;实验组29例,在对照组的基础上沙丁胺醇与丙酸氟替卡松雾化吸入治疗。用药后观察实验组及对照组临床效应、不良反应及住院时间。结果实验组及对照组每组治疗前后1周临床症状评分差异有显著性,实验组FEV1/预计值,PEF/预计值及住院时间较对照组治疗差异有显著性,并且未发现不良反应。结论在常规抗炎、祛痰等治疗基础上加用沙丁胺醇和丙酸氟替卡松联合雾化治疗一周后,患者临床症状评分及肺功能均明显改善,明显缩短了治疗疗程和住院时间,且无严重不良反应。 相似文献
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Lei Wang Wei-lai Xu Hai-tao Meng Wen-bin Qian Wen-yuan Mai Hong-yan Tong Li-ping Mao Yin Tong Jie-jing Qian Yin-jun Lou Zhi-mei Chen Yun-gui Wang Jie Jin 《Journal of Zhejiang University. Science. B》2010,11(10):762-770
Mutations of fms-like tyrosine kinase 3 (FLT3) and nucleophosmin (NPM1) exon 12 genes are the most common abnormalities in adult acute myeloid leukemia (AML) with normal cytogenetics. To assess the prognostic impact of the two gene mutations in Chinese AML patients, we used multiplex polymerase chain reaction (PCR) and capillary electrophoresis to screen 76 AML patients with normal cytogenetics for mutations in FLT3 internal tandem duplication (FLT3/ITD) and exon 12 of the NPM1 gene. FLT3/ITD mutation was detected in 15 (19.7%) of 76 subjects, and NPM1 mutation in 20 (26.3%) subjects. Seven (9.2%) cases were positive for both FLT3/ITD and NPM1 mutations. Significantly more FLT3/ITD aberration was detected in subjects with French-American-British (FAB) M1 (42.8%). NPM1 mutation was frequently detected in subjects with M5 (47.1%) and infrequently in subjects with M2 (11.1%). FLT3 and NPM1 mutations were significantly associated with a higher white blood cell count in peripheral blood and a lower CD34 antigen expression, but not age, sex, or platelet count. Statistical analysis revealed that the FLT3/ITDpositive group had a lower complete remission (CR) rate (53.3% vs. 83.6%). Survival analysis showed that the FLT3/ITD-positive/NPM1 mutation-negative group had worse overall survival (OS) and relapse-free survival (RFS). The FLT3/ITD-positive/NPM1 mutation-positive group showed a trend towards favorable survival compared with the FLT3/ITD-positive/NPM1 mutation-negative group (P=0.069). Our results indicate that the FLT3/ITD mutation might be a prognostic factor for an unfavorable outcome in Chinese AML subjects with normal cytogenetics, while NPM1 mutation may be a favorable prognostic factor for OS and RFS in the presence of FLT3/ITD. 相似文献
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目的:探讨急性力竭运动及恢复期过程中肾脏TXA2/PGI2代谢平衡调节的生物学效应及自由基代谢的介导作用。方法:SD大鼠随机分为安静对照组、运动后即刻组、运动后1 h组、3 h组和24 h组,各运动组采用递增负荷跑台运动至力竭方案,测定肾组织中TXB2、6-keto-F1α和MDA含量和SOD活性。结果:运动后即刻肾脏TXB2含量和TXB2/6-keto-F1α比值均显著下降,恢复期TXB2含量和TXB2/6-keto-F1α比值均显著低于安静水平。运动及恢复期肾组织SOD活性、MDA含量与TXB2、6-keto-F1α含量均呈显著负相关。结论:力竭运动及恢复期肾脏TXA2/PGI2平衡均下调,运动中有利于维持肾脏局部基本的血液供应,可能与运动性肾脏缺血激发局部代偿机制有关,恢复期则促进肾脏血液再灌注和恢复血供。肾脏抗自由基能力提高可能主要通过抑制肾脏TXA2合成下调TXA2/PGI2平衡。 相似文献
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全球处于亚健康状态的人越来越多,亚健康已引起社会的广泛关注.运动被认为是治疗亚健康的1种重要手段,但是并非所有的运动都能增进健康,剧烈运动或过度训练导致亚健康,本文查阅大量资料并提出合理运动的观点,正确指导人们科学健身,预防和治疗亚健康,以达到增进健康的目的. 相似文献
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Li BA ;Ding-qian WU ;An-yu QIAN ;Mao ZHANG ;Bing XIONG 《Journal of Zhejiang University. Science. B》2014,15(12):1023-1031
研究目的：创新要点：研究方法：重要结论：探讨严重创伤患者早期血清胆碱酯酶（ChE）活性的动态变化规律与临床意义。阐明了在严重创伤后早期血清ChE动态的变化规律,为评估创伤的严重程度和预后判断提供新的参考辅助指标。前瞻性观察研究：分析81例严重创伤患者伤后第1、3、7天血清ChE活性的动态变化,通过亚组（不同预后、不同伤情严重程度）间变化比较及与损伤严重度评分（ISS）、急性生理和慢性健康评分Ⅲ（APACHEⅢ）和创伤严重程度评分（TRISS）进行比较,评估其反映病情严重程度和预后的价值;同时分析伤后血清ChE活性与急性期蛋白（APP）,如白蛋白（ALB）、前白蛋白（PAB）、转铁蛋白（TRF）和C反应蛋白（CRP）浓度变化的关系。血清ChE活性在严重创伤后显著降低,持续下降的幅度越大,则提示损伤越重,预后可能越差,而且血清ChE或可视为负急性期蛋白的一种,血清ChE作为严重创伤伤情和预后评估的简单辅助指标具有一定的可靠性。 相似文献
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Simbita A. Marwah Hitesh Shah Kiran Chauhan Amit Trivedi N. Haridas 《Indian journal of clinical biochemistry : IJCB》2014,29(2):161-166
Currently employed markers for the detection of acute coronary syndrome are Troponin T, CK (Creatine Kinase) and CKMB activity. CKMB activity measured by immunoinhibition method can give falsely elevated results due to the presence of atypical CK and CKBB and at times lead to the mis-diagnosis of acute coronary syndrome. Hence, CKMB mass (CKMB) measured by electrochemiluminence sandwich principle was employed. In this cross-sectional study 183 samples of 61 patients were analyzed within 6 h of diagnosis of acute coronary syndrome and followed up to 72 h. The correlation coefficient between CKMB activity and CKMBM at 4–6 h was 0.744, while at 12–24 h it was 0.909 and at 48–72 h it was 0.337. Thus there was good association between the two methods at 12–24 h but, statistically for method comparison studies and for replacing one method by another, the two methods need to be in agreement with one another. In this study the two methods are not in agreement with one another and thus analytically not replaceable. Another finding was obtained that CKMBM reached cut off levels prior to CKMB enzyme activity and hence, CKMBM is clinically better than CKMB activity to detect reinfarction. 相似文献
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Kritsanee Maneewong Titiporn Mekrungruangwong Saowanee Luangaram Tomon Thongsri Sarawut Kumphune 《Indian journal of clinical biochemistry : IJCB》2011,26(4):389-395
Ischemia modified albumin (IMA) and Protein Carbonyl (PC) have known as proteins that are modified on the similar basis of
oxidative stress induced protein modification and may have diagnostic potential in acute myocardial infarction. This study
aims to evaluate the ability of using IMA and PC content to diagnose Non-ST elevation myocardial infarction (NSTEMI) and efficiency
of combining these two markers. Serum from NSTEMI and healthy control were determined for serum IMA and PC content. The results
showed that both of serum IMA level and PC content in NSTEMI was significantly higher than that of healthy controls. However,
the PC content showed greater diagnostic performance than IMA. Combinatorial determination of serum IMA level with PC content
level was enhanced test efficiency. In conclusion, our finding demonstrated that IMA and PC content can be used as a diagnostic
marker for NSTEMI. 相似文献
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