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91.
目的：研究急性应激对小鼠空间学习记忆的影响及其机制。方法：以足底电击来建立急性应激小鼠模型，采用Morris水迷宫检测小鼠空间学习记忆能力，以免疫组化方法检测神经营养因子-3(NT-3)在小鼠海马和前脑皮层的表达。结果：水迷宫实验中，急性应激组小鼠与对照组相比，空间学习记忆显著提高(P<0.01)。在海马CA1区、CA3区、齿状回及前脑皮层NT-3的表达显著增强(P<0.05，P<0.01)。结论：急性应激所致小鼠空间学习记忆功能的提高可能与脑内NT-3表达上调相关。 相似文献
92.
Fleming JJ Janardhan HP Jose A Selvakumar R 《Indian journal of clinical biochemistry : IJCB》2011,26(1):32-40
In the present study, the cause of suspected false-positive (anomalous) values for CK-MB activity, in Indian patients investigated
for ACS. Total serum CK and CK-MB activity, serum Troponin I were measured and CK-MB as a percentage of the total CK activity
(%CK-MB) calculated. CK-MB was also estimated using densitometry and CK-MB mass assay. Anomalous specimens were tested for
the presence of CK isoenzymes. In 22 healthy subjects, 11 male and female, the %CK-MB ranged from 3.6 to 30.2. In 11 male
patients, with proven ACS, the %CK-MB was from 4.0 to 17.5. The cut off for anomalous CK-MB activity values was set as >33.0%.
In 35 patients with anomalies, total CK values ranged from 39 to 231 U/L, CK-MB from 30 to 161 U/L. Investigation of CK isoenzymes,
showed 10 patients had a CK-BB band, 14 an intermediate band between CK-MM and CK-MB (macro-CK type 1), 7 had a cathodal band
(macro-CK type 2), and 3 had a band intermediate between CK-MB and CK-BB. This later band does not seem to have been previously
reported. Against the CK-MB mass assay, the activity assay showed no correlation, in 43 patients (19 M, 24 F), Pearson coefficient
(R2) was 0.006. The CK-MB immunoinhibition assay is better described as measuring “non-CK-MM activity.” A %CK-MB activity >6%
as a marker of ACS is not valid in our patient population. Laboratories should not use only CK-MB activity as a biochemical
marker of ACS. 相似文献
93.
目的:探讨外用中药塌渍联合TDP红外线照射治疗阴囊急性湿疹的疗效观察和护理体会。方法:选取诊断为急性湿疹患者150例,按随机数字表法分为两组,西药对照组采用口服盐酸西替利嗪治疗,中药观察组在对照组的基础上外用中药塌渍联合TDP红外线照射。比较两组的疗效。结果:观察组总有效率为100%,对照组为86.6%,观察组疗效明显优于对照组(P0.05)。结论:中药塌渍联合TDP红外线照射治疗阴囊急性湿疹可有效提高临床疗效,简便易于掌握,患者更易接受。 相似文献
94.
Pradeep Naik Venkataraman Sritharan Premsagar Bandi Mallikarjuna Madhavarapu 《Indian journal of clinical biochemistry : IJCB》2013,28(1):38-45
Liver transplantation means surgical replacement of a diseased liver with a healthy liver. The survival rate used to be 30 % after 1 year and LTx was considered to be the last procedure when all medical or surgical intervention failed. Advances in donor organ preservation, surgical techniques, patient selection, immunosuppressive regimens and treatments for opportunistic infections all have contributed to substantially improve the survival rates. Despite substantial technological, medical and surgical advances, liver transplantation remains a complex procedure that is accompanied by significant morbidity and mortality. The post-operative outcome of each patient varies greatly depending on the patient’s pre- operative state, quality of the donated organ and the complexity of the surgery. Complications occur both immediately post transplant and in the long term. Most of the problems can be satisfactorily assessed with a panel of routine LFTs results of which are generated quickly, cheaply on the analyzer which operates 24 h. Liver Function Test identifies the presence of problem but not problem itself. Abnormal results can be meaningful only when used with clinical data, radiological findings. The study includes 75 post LTx patients in three groups adults (non ACR), Pediatrics and ACR. All recipients were on immunosuppressive therapy (tacrolimus, mycophenolate and methylprednisolone), antiviral (ganciclovir), antiprotozoal, antibacterial and antifungal (fluconazole). 5 mL of blood was drawn in plain vacutainer from the post LTx patients every day for 15 days and LFT and GGT was done. Routinely performed liver function tests correlates well with clinical complications involving liver in the transplant patients. Instead of daily testing, may be alternate day analysis of LFT should be sufficient for effective monitoring of patients. The total protein and albumin and the transaminases offer little help in monitoring LFT post LTx. The elevated levels of serum GGT and ALP may be related to chronic immune damage to the transplanted liver. Serum GGT and ALP can be used as early markers for diagnosing biliary complications and can be used to asses adequacy of endoscopic treatment in the group of patients presenting early. Thus, most of the problems can be satisfactorily assed with a panel of routine LFTs generated quickly, cheaply on analyzer which operates 24 h each day. However, it must be emphasized that LFTs may identify the presence of problems but not the problem itself and the abnormal results are meaningful only when correlated with other clinical information. 相似文献
95.
Siti Balkis Budin Seri Masran Siti Nor Ain Baharuddin Omar Izatus Shima Taib Othman Hidayatulfathi 《Journal of Zhejiang University. Science. B》2012,13(10):783-790
Litsea elliptica Blume has been traditionally used to treat headache, fever, and stomach ulcer, and has also been used as an insect repellent. The acute and subacute toxicities of L. elliptica essential oil were evaluated orally by gavage in female Sprague-Dawley rats. For the acute toxicity study, L. elliptica essential oil was administered in doses from 500 to 4 000 mg/kg (single dose), and in the subacute toxicity test, the following doses were used: 125, 250, and 500 mg/kg, for 28 consecutive days. In the acute toxicity study, L. elliptica essential oil caused dose-dependent adverse behaviours and mortality. The median lethal dose value was 3 488.86 mg/kg and the acute non-observed-adversed-effect level value was found to be 500 mg/kg. The subacute toxicity study of L. elliptica essential oil did not reveal alterations in body weight, and food and water consumptions. The haematological and biochemical analyses did not show significant differences between control and treated groups in most of the parameters examined, except for the hemoglobin, mean cell hemoglobin concentration, mean cell volume, mean cell hemoglobin, serum albumin, and serum sodium. However, these differences were still within the normal range. No abnormalities or histopathological changes were observed in the liver, pancreatic islet of Langerhans, and renal glomerulous and tubular cells of all treated groups. In conclusion, L. elliptica essential oil can be classified in the U group, which is defined as a group unlikely to present an acute hazard according to World Health Organization (WHO) classification. 相似文献
96.
Andrew T. Harveson James C. Hannon Timothy A. Brusseau Leslie Podlog Charilaos Papadopoulos Lynne H. Durrant 《Research quarterly for exercise and sport》2013,84(2):214-216
Purpose: The purpose of this study was to determine differences in cognition between acute bouts of resistance exercise, aerobic exercise, and a nonexercise control in an untrained youth sample. Method: Ninety-four participants performed 30 min of aerobic exercise, resistance exercise, or nonexercise separated by 7 days each in a randomized crossover design. After each exercise intervention, participants were assessed using 2 cognitive tests. The Dot, Word, and Color elements of the Stroop Test (Victoria version) and Parts A and B of the Trail-Making Test were used to measure cognition. Results: Acute resistance and aerobic exercise resulted in similar improvements over nonexercise in all forms of the Stroop Test. Acute aerobic exercise led to improved performance over nonexercise and resistance exercise in Part B of the Trail-Making Test. Neither exercise intervention showed significant changes in time to complete Part A of the Trail-Making Test. Boys outperformed girls on the Stroop Dot and Color Test following acute aerobic exercise, in the Stroop Dot, Word, and Color Test following acute resistance exercise, and in the Stroop Color Test and Trail-Making Test Part B following nonexercise. Conclusions: Both acute resistance and aerobic exercise increased measures of cognition over a nonexercise control in untrained high school youth. These findings suggest the merits of acute resistance exercise as an alternative or complement to aerobic activity for educators aiming to increase youth physical activity and cognitive function concurrently. 相似文献
97.
In order to assess the possible occurrence of acute haemolysis with prolonged exertion, serum haptoglobin levels were determined from venous blood samples collected from eight male runners immediately preceding (PreRH), immediately following (PRH1), and 6 h following (PRH2) completion of a marathon road race. The subjects’ mean age, percentage of body fat, and maximum oxygen uptake (VO2max) were 46 ± 9 years, 12.1 ± 3.4% and 54.9 ± 8.4 ml kg‐1 min‐1, respectively. The mean race finish time for the subjects was 3:35 ± O: 18 h:min. The PreRH, PRH1 and PRH2 averaged 129 ± 18, 97 ± 48 and 86 ± 35 mg dl‐1 respectively. Significant differences of –32.5 mg dl‐1 between PreRH versus PRH1 and –42.5 mg dl‐1 between PreRH versus PRH2 were found. The difference between PRH1 and PRH2 of –10.6 mg dl‐1 was not significant. No significant correlations were found between the decreases in serum haptoglobin and VO2max or race finish time. The data suggest the occurrence of an acute haemolysis with performance of the marathon road race. 相似文献
98.
INTRODUCTION Magnetic Resonance Electrical Impedance To-mography (MREIT) is a new imaging techniquecombining traditional Electrical Impedance Tomo-graphy (EIT) and Current Density Imaging (CDI) fordetermining conductivity distribution inside a subject(Khang et al., 2002; Kwon et al., 2002). In MREIT, acurrent is injected into the subject through a pair ofsurface electrodes. The induced magnetic flux densityinside the subject can be measured through a Mag-netic Resonance … 相似文献
99.
目的：观察内给氧治疗急性出血坏死性胰腺炎的效果。方法：对2003．4～2006．4月收治的47例经血、尿淀粉酶、B超、CT证实为急性出血坏死性胰腺炎患者，随机分为治疗组和对照组，治疗组给予注射用内给氧＋善德定（善宁）或施他宁、抗生素及基础性支持治疗；对照组予善德定（善宁）或施他宁加抗生素及基础性支持治疗。结果：治疗组腹痛缓解时间、淀粉酶降至正常时间及死亡率均明显少于对照组，差异有非常显著性（P〈0．01）。结论：内给氧配合基础性治疗对重症胰腺炎有较好疗效，具有费用低，实用性强的优点。 相似文献
100.
李春海 《河北北方学院学报(医学版)》2005,22(4):43-44
目的:利用人脐带血干细胞移植治疗兔急性心肌缺血,探索防治缺血性心脏病的新方法.方法:新西兰白兔40只,雌雄不拘.随机等分为实验组和对照组.两组均结扎冠状动脉左前降支中1/2,复制心肌梗死模型.缺血60min后将0.3ml的108/ml人脐带血干细胞注射到实验组兔的缺血区心肌组织,对照组兔缺血区心肌组织中注射等体积的人静脉血.3周后观察心功能、心肌梗死面积和心肌生化指标.结果:实验组的LVSP和左心室最大变化速率均明显高于对照组(P＜0.01),而LVEDP显著低于对照组(P＜0.01).实验组的心肌梗死面积明显小于对照组(P＜0.01),血清CK和MDA的含量也显著低于对照组(P＜0.01),SOD含量则明显高于对照组(P＜0.05).结论:人脐带血干细胞移植能够明显改善兔急性心肌缺血的心功能,减轻氧自由基对心肌的损伤,缩小心肌梗死面积. 相似文献