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41.
Witas HW Jedrychowska-Dańska K Zawicki P 《Journal of Zhejiang University. Science. B》2007,8(7):512-514
The precise etiology and reasons for the increase in incidence of autoimmune disorders still remain unclear, and although both genetic and environmental factors have been proven to shape individual predisposition, it is not known which of the factors, if not both, is responsible for the boom observed during the last decades. In order to establish whether a higher frequency of autoimmune-predisposing alleles may explain this increase we took advantage of ancient DNA methodology to establish the genetic predisposition, conferred by cytotoxic T lymphocyte associated antigen-4 （CTLA4） ＋49A/G and human leukocyte antigens （HLA） DQBI^57, in population inhabiting Poland in the Middle Ages. After successful typing of 42 individuals from a 12th-14th＇s century archeological burial site, we found that frequencies of the predisposing alleles in the medieval population were higher than they are at present, suggesting thus that the recently observed incidence increase results most probably from factors of other than genetic nature. 相似文献
42.
Shilpa Reddy Ganasyam Talluri Bhaskar Rao Y. S. R. Murthy Akka Jyothy Madireddy Sujatha 《Indian journal of clinical biochemistry : IJCB》2012,27(1):69-73
Type 2 diabetes mellitus (DM) is a multifactorial disease where both genetic and environmental factors contribute to its pathogenesis.
Estrogen plays an important role in type 2 DM pathogenesis. A number of polymorphisms have been reported in the estrogen receptor
(ESR1), including the XbaI and PvuII restriction enzyme polymorphisms of ESR1,which may be involved in disease pathogenesis. Metallothioneins (MT) act as potent
antioxidants against various oxidative damages. Very few studies have indicated the association between Estrogen Receptor-α,
MT1 gene polymorphisms with type2 DM. A total of 100 type 2 diabetic women and 100 age, sex matched controls were recruited.
Using the PCR based RFLP method, the PvuII and XbaI polymorphisms of ESR1 and in MT1A (rs8052394 and rs11076161) gene polymorphisms were analysed. The genotype distribution and frequency of mutated allele showed no significant differences
between diabetic and non-diabetic groups in PvuII (χ2 = 2.443; P = 0.1181) or XbaI (χ2 = 1.789; P = 0.1812) and rs8052394 (χ2 = 1.154; P = 0.2840) or rs11076161 (χ2 = 0.4141; P = 0.5199), polymorphisms. This is the first Indian study to conclude that ESR1 and MT1 gene polymorphisms are not associated
with increased susceptibility to type 2 diabetes in Indian women. 相似文献
43.
44.
脂联素(Acrp30)是一种新的由脂肪细胞特异分泌的蛋白,具有调节糖脂代谢、抗炎症反应、抗动脉粥样硬化等多种效应.综述了Acrp30与AS、肥胖、糖尿病、及心血管疾病密切相关以及运动对Acrp30含量变化的影响的研究进展. 相似文献
45.
糖尿病是21世纪一种常见的慢性病，是继心脑血管病和癌症之后的第三大疾病。北京市大约有80万糖尿病患者。其中，大约有76万人属于2型糖尿病。运动可以增强机体对胰岛素的敏感性，有助于降低血糖和血脂，增强体质。开发糖尿病运动处方、开展运动处方对降低血糖的影响的研究对治疗糖尿病，提高居民的健康水平具有重要意义。通过实验证实，按照低强度、长时间、周期性、全身大肌肉群参加的有氧运动为主要锻炼内容的运动处方对降低2型糖尿病患者的血糖有明显的辅助作用，并且不会使血糖升高，对于控制糖尿病的血糖水平有积极意义。 相似文献
46.
脂联素是一个重要的脂肪因子,在糖脂代谢中起着重要的作用,脂联素的低水平与一些疾病,如糖尿病、心血管疾病等有密切联系。对脂联素与相关疾病的关系以及运动对脂联素水平的影响进行了综合分析。并探索了今后的研究方向。 相似文献
47.
运动疗法对糖尿病患者血糖、血脂的影响 总被引：3，自引：0，他引：3
目的：探讨运动疗法对中老年糖尿病患者血糖、血脂的影响和作用。方法：依据省保健干部体检确诊病案,对实验组29名糖尿病患者实施为期一年的运动疗法锻炼,同对照组17名患者作对照。结果：实施运动疗法一年后血糖FBG显著降低,与对照组比较有显著差异（P〈0．01）;甘油三酯TG（P〈0．05）、总胆固醇Tch（P〈0．01）降低明显;高密度脂蛋白胆固醇HDL—ch虽有升高,但差异不显著。结论：（1）运动疗法干预能够有效降低糖尿病患者空腹血糖值,持之以恒其效果更好。（2）运动疗法干预能够消除糖尿病患者体内多余脂肪,降低甘油三酯TG和胆固醇Teh,有效降低心脑动脉粥样硬化的危险性。 相似文献
48.
49.
Nuttikarn Nokkaew Podsawee Mongkolpathumrat Ruttanapong Junsiri Supawit Jindaluang Nichagron Tualamun Niya Manphatthanakan Nareumon Saleesee Marisa Intasang Jantira Sanit Punyanuch Adulyaritthikul Kantapich Kongpol Sarawut Kumphune Nitirut Nernpermpisooth 《Indian journal of clinical biochemistry : IJCB》2021,36(2):228
Microvascular and macrovascular diseases are the main causes of morbidity in type 2 diabetes patients through chronic hyperglycaemic condition via oxidative stress and inflammation. Reactive oxygen species (ROS) activate p38 MAPK phosphorylation and inflammation which enhances protein modification by carbonylation. The use of metformin and a p38 MAPK inhibitor is hypothesised to reduce ROS production and inflammation but effects of metformin and p38 MAPK inhibitor (SB203580) on ROS production and inflammation in vascular type 2 diabetes mellitus non-obese (T2DM) have not been investigated. The Goto-Kakizaki rat T2DM model was divided into three groups as T2DM, T2DM treated with 15 mg/kg bw metformin and T2DM treated with 2 mg/kg bw SB203580 for 4 weeks. Rat aortas were isolated and protein carbonyl (PC) contents were measured by spectrophotometric DNPH assay. Aortic IL-1ß level was determined by ELISA. Results showed that aortic PC contents in the T2DM group were significantly higher than in non-diabetic rats. Treatment with metformin or SB203580 significantly reduced PC contents while only metformin significantly reduced IL-1ß levels. Findings indicated that metformin reduced ROS production and inflammation in diabetic vessels and possibly reduce vascular complications in non-obese T2DM. 相似文献
50.