复肾口服液对阿霉素肾病大鼠肾脏形态的影响     

张淑萍  靳国印  李旺  张晓丽  薄爱华 《河北北方学院学报(医学版)》2007,24(2):9-12

目的：观察复肾口服液对阿霉素肾病大鼠肾脏的形态学影响。方法：采用尾静脉一次性注射阿霉素（ADR）复制肾病综合征模型。用光学显微镜、电子显微镜观察肾小球毛细血管、上皮细胞、基底膜及肾小管的病理形态学改变。结果：复肾口服液能使阿霉素肾病大鼠蛋白尿显著降低，肾小管管腔内的蛋白管型明显减少，肾小球淤血及上皮细胞和基底膜的损伤程度明显减轻，肾小球上皮细胞足突融合明显改善。结论：复肾口服液可促进肾病大鼠肾小球上皮细胞的修复及滤过膜功能的恢复，但存在着量效依赖关系。  相似文献   

The treatment of relapsing primary nephrotic syndrome in children   总被引：2，自引：0，他引：2  

Wang YP  Liu AM  Dai YW  Yang C  Tang HF 《Journal of Zhejiang University. Science. B》2005,6(7):682-685

Objective: To explore better therapy and reduce the rate of re-relapse of primary nephritic syndrome in children who had been treated with corticosteroids but relapsed. Methods: Eighty relapsers were enrolled from Jan. 1994 to Apr. 2000, who were randomly divided into two groups. The treatment group (n=39) had been treated with tripterysium glucosides for three months, with the control group (n=41) members were treated with cyclophosphmide (CTX) by intermission intravenous pulse, with total dose of CTX not being more than 150 mg/kg. Prednisone, meanwhile, was given to both groups. The total treatment period of prednisone was prolonged by 12-18 months. Results: After following up for 3-7 years, the re-relapse rates of both groups were observed. The re-relapse rate of the treatment group was 28.2% to 29.3% in the CTX-controlled group. The re-relapse rates between two groups were almost similar, and with no observed significant difference (P>0.05). The side effect of tripterysium glucosides was less than that of CTX. Conclusion: For the treatment of relapsing nephritic syndrome in children, the combination of tripterysium glucosides and prolonged corticosteroid therapy is as effective as the regimen of CTX plus prolonged use of prednisone.  相似文献   

大学生亚健康状况的调查与分析   总被引：8，自引：0，他引：8  

于霞  王廷俊 《大连大学学报》2005,26(4):74-75,91

[目的]通过对大连市在校大学生心理亚健康状况的调查,分析大学生亚健康状态.[方法]运用文献资料法、调查问卷、数据统计法.[结果]学生对健康含义的认识不全面,没有全面了解健康的内涵和外延,忽视了健康还包括社会适应方面,片面的理解健康,学生平均每天参加体育锻炼的时间少等等.[结论]作为学校体育教育工作者要转变观念,以“健康第一”的指导思想,对学生进行健康教育和指导..正确引导大学生预防和消除亚健康状态.  相似文献   

ADP-ribosylhydrolases: from DNA damage repair to COVID-19     

Lily YU  Xiuhua LIU  Xiaochun YU 《Journal of Zhejiang University. Science. B》2021,22(1):21-30

Adenosine diphosphate(ADP)-ribosylation is a unique post-translational modification that regulates many biological processes,such as DNA damage repair.During DNA repair,ADP-ribosylation needs to be reversed by ADP-ribosylhydrolases.A group of ADP-ribosylhydrolases have a catalytic domain,namely the macrodomain,which is conserved in evolution from prokaryotes to humans.Not all macrodomains remove ADP-ribosylation.One set of macrodomains loses enzymatic activity and only binds to ADP-ribose(ADPR).Here,we summarize the biological functions of these macrodomains in DNA damage repair and compare the structure of enzymatically active and inactive macrodomains.Moreover,small molecular inhibitors have been developed that target macrodomains to suppress DNA damage repair and tumor growth.Macrodomain proteins are also expressed in pathogens,such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).However,these domains may not be directly involved in DNA damage repair in the hosts or pathogens.Instead,they play key roles in pathogen replication.Thus,by targeting macrodomains it may be possible to treat pathogen-induced diseases,such as coronavirus disease 2019(COVID-19).  相似文献   

Effects of angiotensin Ⅱ receptor blocker usage on viral load,antibody dynamics,and transcriptional characteristics among COVID-19 patients with hypertension     

Feng  Baihuan  Zhang  Dan  Wang  Qi  Yu  Fei  Zou  Qianda  Xie  Guoliang  Wang  Ruonan  Yang  Xianzhi  Chen  Weizhen  Lou  Bin  Zheng  Shufa  Chen  Yu 《Journal of Zhejiang University. Science. B》2021,22(4):330-340

  相似文献   

Structural and physiological changes of the human body upon SARS-CoV-2 infection     

Wu  Zhonglin  Zhang  Qi  Ye  Guo  Zhang  Hui  Heng  Boon Chin  Fei  Yang  Zhao  Bing  Zhou  Jing 《Journal of Zhejiang University. Science. B》2021,22(4):310-317

Since December 2019, the novel coronavirus(severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)) has spread to many countries around the world, developing into a global pandemic with increasing numbers of deaths reported worldwide. To data, although some vaccines have been developed, there are no ideal drugs to treat novel coronavirus pneumonia(coronavirus disease 2019(COVID-19)). By examining the structure of the coronavirus and briefly describing its possible pathogenesis based on recent autopsy reports conducted by various teams worldwide, this review analyzes the possible structural and functional changes of the human body upon infection with SARS-CoV-2. We observed that the most prominent pathological changes in COVID-19 patients are diffuse alveolar damage(DAD) of the lungs and microthrombus formation,resulting in an imbalance of the ventilation/perfusion ratio and respiratory failure. Although direct evidence of viral infection can also be found in other organs and tissues, the viral load is relatively small. The conclusion that the injuries of the extrapulmonary organs are directly caused by the virus needs further investigation.  相似文献   

经尿道气化电切治疗前列腺增生60例手术疗效分析     

王慎鸿 《科技通报》2002,18(5):433-435,440

目的：探讨经尿道前列腺气化电切（TUVP）治疗前列腺增生症（BPH）的临床效果。方法：采用电气化加修切法施行经尿道前列腺电气化术治疗BPH60例。结果：全部患者手术均获成功，平均手术操作时间40min，平均留置导尿时间3．5天，平均住院日5．5天。结论：TUVP是治疗BPH的有效方法，比经尿道前列腺电切术（TUPR）更具广泛的应用优势，但必须具有良好的技术及解剖基础，同时要熟练气化电切镜的各种功能及操作过程。  相似文献   

Teaching students with Down syndrome in regular classrooms in Ghana: views of secondary school mathematics teachers     

Maxwell Peprah Opoku  Richard Tawiah  Elvis Agyei-Okyere  Shaibu Osman  Sally Adwoa Afriyie 《International Journal of Disability, Development & Education》2019,66(2):218-232

ABSTRACT

The recent development of making secondary school education free in Ghana has raised concerns about the level of preparedness of teachers to teach students with diverse needs in one classroom. Significantly, mathematics is one of the core areas that the Ghanaian government has prioritised, and it has institutionalised mechanisms to encourage participation by many students. Accordingly, this qualitative study aimed to document the level of preparedness of mathematics teachers to support the teaching of students with Down syndrome in secondary school classrooms. Twenty-seven mathematics teachers from 14 schools, made up of 18 males and nine females, took part in the study. We found that participants were in favour of implementation of inclusive education. However, regarding the prospect of teaching students with Down syndrome, most of the participants thought that the regular secondary school classroom is not a suitable environment for these students to access education, especially due to a number of challenges. The need for the government to support schools with appropriate teaching materials and facilities is discussed extensively.  相似文献   

三大学科群方法问题沉思录   总被引：4，自引：0，他引：4  

栾栋 《华中师范大学学报(人文社会科学版)》2001,40(4):85-90

人学科、社会科学和自然科学三大学科在方法论上各有当下的侧重点,它们分别是化感通变、实事求是和格物致知。三大学科群方法在秉性上的差别和际遇方面的利钝,造成了价值取舍的不同向度和学术品位的奇光异彩;三位一体的异质同构、多元方法的涵摄共和以及互补互动的擒纵机括,是分久心合,合中有异,异以致和的天人共鸣。“此当重坤”是纠正学科群偏颇和治疗明综合症的纲领口号,也是地球村明向太阳系明过渡的战略方针。  相似文献   

Verbal Fluency and Verbal Short-Term Memory in Adults with Down Syndrome and Unspecified Intellectual Disability     

Panayiota Stavroussi  Georgia Andreou  Dimitra Karagiannopoulou 《International Journal of Disability, Development & Education》2016,63(1):122-139

The purpose of this study was to examine verbal fluency and verbal short-term memory in 12 adults with Down syndrome (DS) and 12 adults with Intellectual Disability (ID) of unspecified origin, matched for receptive vocabulary and chronological age. Participants’ performance was assessed on two conditions of a verbal fluency test, namely, semantic and phonemic fluency. In addition to the total number of correct words produced, the use of clustering and switching strategies was also evaluated. In order to investigate the likely relations of verbal short-term memory with the test variables, a digit span task was administered. According to the results of the study, the two groups differed significantly on the average phonemic cluster size, with the ID group outperforming the DS group. Regarding the within-group comparisons, a relatively similar pattern of results was found for the two groups, indicating higher scores on all the measures involved in the semantic test than the phonemic one. The examination of the relation of verbal short-term memory with the verbal fluency test measures revealed that, in the DS group, only the total words produced in the semantic and the phonemic test and the number of phonemic switches were significantly associated with verbal short-term memory. Additionally, in both groups, word productivity in the semantic and the phonemic test was positively associated with the number of switches. The observed similarities and differences in the performance of the two groups, as well as the associations that emerged among the test variables in each group, are discussed.  相似文献