Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

健身瑜伽对中老年女性慢性腰痛的防治研究   总被引：6，自引：0，他引：6  

陈丽霞 《北京体育大学学报》2006,29(1):85-86,109

为研究健身瑜伽对中老年女性慢性腰痛的防治效应,将70名中老年慢性腰痛病人分成A、B两组,C组由正常组35名无腰痛病史的中老年女性组成.对A、C进行9个月健身瑜伽训练.运用Neuromatic 2000 M/C神经肌电仪测试各组训练前后骶棘肌肌电指标,PPX-L型双能X线骨度仪测量各组训练前后骨密度值,分别进行组间比较.结果:慢性腰痛组(A、B)训练前腰背肌波幅低于正常组(P<0.01)时程大于正常组(P<0.01),训练之后腰痛组(A)和正常组(C)波幅都得到提高(P<0.01和P<0.05)时程都降低(P<0.01和P<0.05).疗效评定得出慢性腰痛治愈显效率达82.86%.结论:健身瑜伽对中老年女性慢性腰痛具有较好的防治作用.  相似文献   

一些训练手段和技术对国家游泳队运动员肩痛影响的调查与分析     

王道  沈海瑛  林洪 《体育科研》2006,27(5):70-73

采用问卷调查法和访问调查法调查访问了81名国家游泳队运动员和15名国家游泳队教练。结果发现：国家游泳队运动员肩痛患病率为39．5%,男女之间无显著性差异。肩痛患病率最高的是蝶泳运动员(63．6%),其次是自由泳和仰泳运动员,蛙泳运动员肩痛患病率最低(31．3%)：水上训练手段中,短距离高强度戴划手掌训练、长距离中低强度戴划手掌训练和水上铁片牵引训练对肩痛的影响程度列前3位(明显影响率分别为46．7%、25%和18．2%)；陆上训练手段中,铁片拉力训练、卧推练习和等动拉力训练对肩痛的影响程度列前3位(明显影响率分别为43：8%、36．7%和19．4%)。陆上铁片拉力训练时采用高肘技术、抓水时早发力早加速后划技术和陆上铁片拉力训练时后划到底技术是前3位对国家游泳队运动员肩痛有影响的技术动作(明显影响率分别为60%、40%和33．3%)。  相似文献   

男子青少年体操运动员肘、腕关节劳损性伤痛的防治     

魏旭波 《湖北体育科技》1996,(3)

男子青少年体操运动员肘关节、腕关节劳损性伤痛是训练中的一种常见多发性运动损伤，严重阻碍了训练计划的执行和运动技术的提高。本文分析和研究了伤痛形成的各种原因，并提出了预防、治疗的基本方法。  相似文献   

改良小梁切除与传统小梁切除的疗效观察研究     

陈世会  黄胜 《铜仁职业技术学院学报》2006,(4)

目的:评价小梁切除术中改良巩膜瓣、睫状突定量小梁切除、不同缝合方式在术中术后的优缺点及远期疗效。方法120例(156眼)原发性青光眼随机分为4组:A组(传统术式组)30例(42眼);B组(可拆褥式缝线组)30例(40眼);C组(L形巩膜瓣小梁切除组)30例(34眼);D组(小切口睫状突定量小梁切除术组)3 0例(40眼),B.C.D组为改良术式组。比较4组术后浅前房、眼压和滤过泡情况。结果:浅前房发生率:A组26.119%(11/42),B组7.50%(3/40),C组2.94%(1/34),D组2.50%(1/40),改良术式组与传统术式组比较差异有板有统计学意义(P<0.01);随诊眼压:A组(14.65±4.30)mmHg,B组(1 3.87±3.60)m mHg,C组(15.58±3.20)mmHg,D组(14.50±3.15)mmHg,4组间差异无统计学意义(P>0.05);随诊功能性滤过泡A组76.19%(32/42),B组92.50%(37/40),C组97.05%(33/34),D组95.00%(38/40),传统小梁切除组与改良小梁切除组比较差异有统计学意义(P<0.05)。结论采用巩膜瓣可拆褥式缝合、L形巩膜瓣小梁切除、小切口睫状突定量小梁切除可大大降低术后浅前房的发生率,并能理想地控制眼压,提高术后视功能。  相似文献   

"优秀生心理综合症"及运动处方   总被引：1，自引：1，他引：0  

何新宏  安平 《体育成人教育学刊》2004,20(4):87-88

成绩优秀的学生往往存在一些特殊的心理问题，预防和消除优秀生的心理问题具有十分重要的意义。在进行体育教学和身体锻炼的同时，适当地运用运动处方，可以治疗优秀学生的心理疾病和消除心理障碍，促进优秀学生健康成长。  相似文献   

论英译汉中的常见错误与对策     

陈冬秀 《柳州师专学报》2004,19(4):51-55

分析了英译汉过程中的常见错误或问题(翻译综合症)，同时指出产生这些错误的原因，并在此基础上提出了解决问题的对策。  相似文献   

Effects of interval aerobic training combined with strength exercise on body composition,glycaemic and lipid profile and aerobic capacity of obese rats     

Irene Coll-Risco  Virginia A. Aparicio  Elena Nebot  Daniel Camiletti-Moirón  Rosario Martínez  Garyfallia Kapravelou 《Journal of sports sciences》2016,34(15):1452-1460

The purpose of this study was to investigate the effects of interval aerobic training combined with strength exercise in the same training session on body composition, and glycaemic and lipid profile in obese rats. Sixteen lean Zucker rats and sixteen obese Zucker rats were randomly divided into exercise and sedentary subgroups (4 groups, n = 8). Exercise consisted of interval aerobic training combined with strength exercise in the same training session. The animals trained 60 min/day, 5 days/week for 8 weeks. Body composition, lipid and glycaemic profiles and inflammatory markers were assessed.

Results showed that fat mass was reduced in both lean and obese rats following the exercise training (effect size (95% confidence interval (CI)) = 1.8 (0.5–3.0)). Plasma low-density lipoprotein–cholesterol and fasting glucose were lower in the exercise compared to the sedentary groups (d = 2.0 (0.7–3.2) and 1.8 (0.5–3.0), respectively). Plasma insulin was reduced in exercise compared to sedentary groups (d = 2.1 (0.8–3.4)). Some exercise × phenotype interactions showed that the highest decreases in insulin, homeostatic model assessment-insulin resistance, fasting and postprandial glucose were observed in the obese + exercise group (all, P < 0.01). The findings of this study suggest that interval aerobic training combined with strength exercise would improve body composition, and lipid and glycaemic profiles, especially in obese rats.  相似文献   

Influence of moderate intensity physical activity levels and gender on conditioned pain modulation     

Masataka Umeda  Wanseok Lee  Courtney A. Marino  Shelby C. Hilliard 《Journal of sports sciences》2016,34(5):467-476

This study examined the potential influence of moderate intensity physical activity (PA) levels and gender on central pain modulation using conditioned pain modulation (CPM) in healthy men and women. Twenty four individuals (12 men and 12 women) who reported engaging in the moderate intensity PA for 150 min or more per week and 24 individuals (12 men and 12 women) who reported engaging in moderate intensity PA for 60 min or less per week completed a self-report PA questionnaire and a 7-day PA assessment using an accelerometer. Furthermore, the participants completed the CPM testing to evaluate the efficiency of central pain modulation. The active individuals scored higher on the PA questionnaire and spent more minutes for light, lifestyle, moderate and vigorous intensity PA than the less active individuals. The active men and women exhibited comparable magnitudes of CPM, and showed a greater magnitude of CPM when compared to their less active counterparts. However, these beneficial effects of higher dose moderate intensity PA disappeared when time spent for vigorous intensity PA was statistically controlled for. These results suggest that the higher dose moderate intensity PA does not add to the benefits from vigorous intensity PA to further improve central pain modulatory systems.  相似文献   

对虾白斑综合症病毒囊膜蛋白Vp28基因的克隆、表达及蛋白纯化     

吴小婷  陈曦  陈宇  刘斌  吴文林 《泉州师范学院学报》2011,29(4):41-44

以对虾白斑病毒DNA为模板扩增出Vp28基因,经限制性内切酶（SmaI,Not I）酶切后按正确的读码框顺序插入到pGEX-4T-2表达载体上,重组质粒转化大肠杆菌,经菌落PCR和质粒双酶切鉴定、序列测定确认,证实成功地构建了Vp28基因原核表达载体．转化菌经IPTG诱导表达,SDS-PAGE显示有与预期大小约52kD相吻合的融合蛋白带,18℃诱导24h后获得了可溶性表达的目的蛋白,采用Glutathione Sepharose 4B亲和层析对重组蛋白进行纯化,获得了纯度很高的目的蛋白．  相似文献