Applying machine learning approaches to improving the accuracy of breast-tumour diagnosis via fine needle aspiration     

YUAN Qian-fei  CAI Cong-zhong  XIAO Han-guang  LIU Xing-hua 《重庆大学学报(英文版)》2007,6(1):1-7

Diagnosis and treatment of breast cancer have been improved during the last decade; however, breast cancer is still a leading cause of death among women in the whole world. Early detection and accurate diagnosis of this disease has been demonstrated an approach to long survival of the patients. As an attempt to develop a reliable diagnosing method for breast cancer, we integrated support vector machine (SVM), k-nearest neighbor and probabilistic neural network into a complex machine learning approach to detect malignant breast tumour through a set of indicators consisting of age and ten cellular features of fine-needle aspiration of breast which were ranked according to signal-to-noise ratio to identify determinants distinguishing benign breast tumours from malignant ones. The method turned out to significantly improve the diagnosis, with a sensitivity of 94.04%, a specificity of 97.37%, and an overall accuracy up to 96.24% when SVM was adopted with the sigmoid kernel function under 5-fold cross validation. The results suggest that SVM is a promising methodology to be further developed into a practical adjunct implement to help discerning benign and malignant breast tumours and thus reduce the incidence of misdiagnosis.  相似文献   

衡水湖湿地园林树木臭椿沟眶象发生状况调查     

武大勇  张勋  安海龙  杨晓  彭吉栋  刘鹏艳 《衡水学院学报》2011,13(1):1-3

2009年9月调查了衡水湖北堤不同园林树木上臭椿沟眶象的发生情况,对不同园林树木上臭椿沟眶象的分布和臭椿树上距地面不同距离树干段(0～1 m,1～2 m,2～3 m)上的臭椿沟眶象分布进行了数量统计.结果显示在衡水湖北堤,臭椿沟眶象不在火炬和槐树等其它园林树木上发生,只发生在臭椿树上,并且不同地点臭椿沟眶象的发生状况没有明显的区别,不同臭椿树树干段之间臭椿沟眶象的发生情况也没有显著差异;同时臭椿沟眶象在臭椿树上的发生状况和臭椿树的胸径没有明显关系.  相似文献   

Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins     

D. Jain  A. Ray  A. K. Bahadur  K. U. Chaturvedi  R. Sood  S. Sharma  S. L. D. Naik  B. K. Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(1):42-51

There are numerous growing evidences of resemblance between carcinomas of the breast and prostate. A total of 45 cases of these two hormone-dependent cancers along with appropriate controls were subjected for status of epidermal growth factor receptors as well as serum lipid profile. Paraffin embedded tissue sections from aforesald tumours were analysed by immunohistochemical staining for epidermal growth factor receptor (EGF-R), c-erbB-2 oncoprotein, estrogen receptor (ER) and progesterone receptor (PgR). Sera from same individuals were studied for serum lipid profile analysis. The study revealed that immunoexpression of all receptor proteins (EGF-R). c-erbB-2 was significantly higher in breast carcinoma. In addition, mean levels of triglycerides, total cholesterol, LDL-cholesterol were found to be significantly elevated while the level of HDL-cholesterol was observed to be lower among patients with breast cancer as compared to matched controls. Further, ER-positive breast cancer cases have significantly higher mean level of HDL-cholesterol when compared with ER-negative breast cancer patients. Contrary to this, no alteration in different serum lipid fractions was noticed among the patients with prostate cancer. However, a positive relationship was noticed between immunoexpressions of EGF-R and c-erbB-2 in prostate cancer.  相似文献   

性激素受体和基因蛋白在乳腺癌中表达的研究     

肖广显  丁素银  李月云  童重新  龚建爱  薄爱华 《河北北方学院学报(医学版)》1998,(2)

收集乳腺癌手术切除标本73例,采用酶联组织化学方法,检测ER、PR。结果表明阳性率分别为78.08％、60.27％。利用免疫组织化学方法检测Bcl-2和c-fos基因蛋白,结果表明阳性率分别为79.25％和56.92％。对它们表达的意义进行讨论。  相似文献   

Correlation of Levels of IL-6 with Tumor Burden and Receptor Status in Patients of Locally Advanced Carcinoma Breast     

Binita Goswami  Pankaj Mittal  Nikhil Gupta 《Indian journal of clinical biochemistry : IJCB》2013,28(1):90-94

Inflammatory pathways have garnered considerable interest in the recent past as an important mediator of the molecular mechanisms leading to carcinogenesis. The present study was conducted to evaluate the correlation of levels of IL-6 with tumor burden and receptor status in patients of locally advanced carcinoma breast. This prospective study was conducted by the collaborative efforts of the departments of Surgery and Biochemistry, Maulana Azad Medical College and associated Lok Nayak Hospital and GB Pant Hospitals, New Delhi. The study population comprised of 30 cases of locally advanced breast carcinoma recruited from the surgical outpatient department. The various parameters that were evaluated include detailed clinico-pathological profile and IL-6 levels. Tissue specimens received after surgeries were examined for the various characteristics indicative of tumor prognosis. Majority of the patients was in the age group of 41–50 years and was postmenopausal. The serum level of IL-6 increased as the disease progressed from T3N1M0 to T4dN2M0 (41.4 ± 31.9 vs. 164.0 ± 31.1 pg/ml respectively). There was significant correlation of IL-6 levels with lymph node involvement, tumor grade, mitotic index and adipose tissue invasion. Emerging molecular markers are being investigated for breast cancer prognosis assessment and prediction of response to chemotherapy including selection of best possible treatment modality. Our study showed that there is progressive increase in IL-6 levels as the stage of disease progresses.  相似文献   

乳腺癌中bag-1的表达及与腋窝淋巴结转移的关系     

贠军  易军  王廷  姚青  王岭  张聚良  李晓军 《少年体育训练》2006,(3)

目的探讨乳腺癌组织中bag-1的表达及其与肿瘤细胞增殖和腋窝淋巴结转移的关系。方法收集100例乳腺癌,其中有腋窝淋巴结转移的58例。采用免疫组化SABC法检测bag-1的表达情况。结果bag-1在乳腺癌组织中阳性表达率为85.0%;在I、II、III期的乳腺癌中bag-1阳性表达率分别为87.5%,82.4%,88.2%,三者无明显差异(P>0.05);有腋窝淋巴结转移的乳腺癌中bag-1阳性表达率为89.6%,无腋窝淋巴结转移的乳腺癌中bag-1阳性表达率为78.6%,无明显差异(P>0.05)。结论乳腺癌中bag-1高表达,其表达与肿瘤细胞增殖和腋窝淋巴结转移无关。  相似文献   

C-erbB-2、ER和PR在乳腺癌中的表达与预后意义     

李向东 《少年体育训练》2006,(3)

目的了解乳腺癌C-erbB-2、ER和PR的表达与预后的关系。方法应用免疫组化方法检测乳腺癌C-erbB-2、ER和PR蛋白表达。结果乳腺癌淋巴结转移组C-erbB-2的阳性表达高于未转移组,ER和PR的阳性表达低于未转移组;C-erbB-2阳性表达在I级、II级和III级之间呈明显上升趋势。结论ER、PR阴性病人伴随着较高的C-erbB-2阳性表达,在乳腺癌中预后较差  相似文献   

Review：BRCA1/2 associated hereditary breast cancer     

Teng LS  Zheng Y  Wang HH 《Journal of Zhejiang University. Science. B》2008,9(2):85-89

Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers. Project supported by the National Natural Science Foundation of China (No. 30772510) and the Joint Program of Ministry of Health and Zhejiang Provincal Government of China (No. WKJ2006-2-008)  相似文献   

乳腺癌ER、PR、HER-2癌基因的表达及其意义的研究   总被引：2，自引：0，他引：2  

易少波  黄少敏  付小一 《宜春学院学报》2004,26(2):74-76

目的：探讨乳腺癌ER、PR、HER-2癌基因的表达的病理学意义．方法：应用免疫组织化学超敏SP法，检测106例乳腺癌ER、PR和癌基因HER-2的表达，45例乳腺增生症及乳腺纤维腺瘤HER-2的表达，并按照FDA推荐的DACO公司Hercep Test的标准对HER-2的表达强度进行评分．分析ER、PR和癌基因HER-2的表达与乳腺癌的组织病理学关系．结果：乳腺癌ER阳性率为51．88％，PR阳性率为44．34％，HER-2的阳性率为71．69％，而且ER、PR阳性率随着乳腺癌级数增加(恶性程度增加)而降低；ER、PR的阳性率与淋巴结转移有关联．HER-2阳性程度的增生，乳腺疾病的危险程度随之增加，乳腺癌的恶性程度也相应增加；结论：同时检测乳腺癌ER、PR和HER-2的表达，不仅对指导临床判断疾病的预后有重要参考价值，而且可为临床制定乳腺癌的综合治疗方案提供依据．  相似文献   

Serum lipids, lipoproteins and sex-hormone binding globulin in breast cancer     

A. Ray  S. L. Dayalu Naik  A. K. Bahadur  S. T. Pasha  R. S. Rautela  B. K. Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(1):101-105

Serum levels of various lipid parameters, i.e., triglycerides, total cholesterol, alpha lipoprotein or high density lipoprotein (HDL)-cholesterol and beta lipoprotein or low density lipoprotein (LDL)-cholesterol were measured in a total of 138 histologically proven cases of breast cancer along with 146 control women. The mean levels of serum triglycerides, total cholesterol and LDL-cholesterol were found to be significantly higher in breast cancer cases as compared to controls. However, lower mean levels of serum HDL-cholesterol and sex-hormone binding glubulin (SHBG) were observed in breast cancer patients than the control subjects. The results indicate a probable relation between serum lipids and the activity of sex-hormones. Moreover, the study reflects an overall disturbance of lipid metabolism in the pathological process of breast cancer.  相似文献