运动性与病理性心肌肥厚对比研究进展(综述)     

漆正堂  潘进  许豪文 《体育学刊》2002,9(3):41-42,45

综合分析了分子生物学上的研究成果，说明：（1）Ca^2 是介导心肌细胞肥大的中心环节；（2）心肌成纤维细胞的增殖及其旁（自）分泌功能可能是决定肥厚心肌架构的重要因素，从而揭示运动性心肌肥厚与高血压性心肌肥厚在心脏机能上的差异可能与心肌架构密切相关。  相似文献   

螺旋藻及其复方对运动小鼠心肌线粒体过氧化损伤的保护作用   总被引：3，自引：0，他引：3  

朱梅菊  李红 《中国体育科技》2002,38(4):37-38

实验研究螺旋藻及其复方对运动小鼠心肌线粒体过氧化损伤的保护作用。结果表明 :单味组和复方组小鼠心肌线粒体超氧化物岐化酶 (SOD)活力均高于运动组 (P<0 .0 5和 P<0 .0 1) ,而丙二醛 (MDA)含量均低于运动组 (均为 P<0 .0 1)。复方组小鼠心肌线粒体 SOD活力高于单味组 (P<0 .0 1) ,而 MDA含量低于单味组 (P<0 .0 1)。提示 :螺旋藻及其复方均能减轻运动小鼠心肌线粒体过氧化损伤 ,且复方的效果显著超过单味螺旋藻  相似文献   

过度训练状态下大鼠心肌线粒体病理性变化的研究   总被引：5，自引：1，他引：4  

刘铁民  吴衍忠 《北京体育大学学报》2004,27(2):219-221

为了研究过度训练状态下心肌组织损害的变化规律,采用建立一般训练和过度训练大鼠模型,应用形态学手段和分子生化技术,对训练后两组大鼠心肌线粒体内钙含量、脂质过氧化反应产物丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-px)、超氧化物歧化酶(SOD)、心肌组织匀浆内酸性磷酸酶(Acid Phosphatase,ACP)和β葡萄糖醛酸酶(Beta-glucuronidase,Beta-GLU)、磷脂酶A2(PLA2)等指标做了定位和定量研究.结果表明,第4周末,一般训练组和过度训练组大鼠心肌线粒体内钙含量、MDA和GSH-px、SOD、PLA2活性和心肌ACP、β-葡萄糖醛酸酶的活性未见异常改变(P＞0.05).但是第8周末,过度训练组心肌线粒体内钙、MDA含量和PLA2活性明显升高,GSH含量和SOD活性明显降低;第8周末,心肌ACP和β-葡萄糖醛酸酶明显增加.结果显示过度训练后心肌线粒体的结构和功能发生了明显变化,这些变化是引起过度训练状态下心肌损伤的主要原因.  相似文献   

运动对心肌组织能量代谢的影响   总被引：6，自引：0，他引：6  

房冬梅  冯美云 《体育科研》2002,23(4):16-18

综合分析了安静状态时、运动状态下心肌组织能量代谢的特点及长期运动训练对心肌能量代谢的影响作用。安静状态下 ,心肌组织以有氧代谢供能为主 ,尤其是以血液游离脂肪酸的有氧氧化供能为主。运动时 ,随运动强度的增加 ,心肌组织内源性、外源性能源物质的消耗均增加 ,心肌不但吸收乳酸 ,而且自身也产生乳酸。长期运动训练可以使心肌组织的糖酵解代谢能力、有氧代谢能力均得到提高。  相似文献   

A meta-analysis of randomized trials on clinical outcomes of paclitaxel-eluting stents versus bare-metal stents in ST-segment elevation myocardial infarction patients     

Xiao-hong Pan  Ying-xue Chen  Mei-xiang Xiang  Geng Xu  Jian-an Wang 《Journal of Zhejiang University. Science. B》2010,11(10):754-761

A meta-analysis was performed to address the efficacy and safety of paclitaxel-eluting stent (PES) in ST-segment elevation myocardial infarction (STEMI) patients. A systematic literature search was conducted to identify all randomized clinical trials in mortality, recurrent myocardial infarction (rMI), repeat revascularization (RR), and stent thrombosis (ST). A total of 4190 STEMI patients were enrolled in six randomized trials comparing PES with bare-metal stent (BMS). The pooled repeat revascularization rate was 5.7% in PES group, significantly lower than 10.0% in BMS group with an odds ratio (OR) of 0.56, 95% confidence interval (CI) [0.44, 0.72] (P<0.00001). No significant difference was found between PES and BMS groups in mortality at one year after the indexing procedure (3.9% vs. 5.1%, OR 0.88, 95% CI [0.63, 1.21], P=0.42). Similarly, rMI rate did not differ significantly between the two groups (3.4% vs. 4.1%, OR 0.80, 95% CI [0.56, 1.13], P=0.21). PES was also associated with the comparable pooled rate of definite stent thrombosis with BMS (2.3% vs. 2.4%, OR 0.81, 95% CI [0.52, 1.26], P=0.35). The results show that PES improved clinical outcomes in STEMI patients with a decreased need for repeat revascularization and no concerns for safety.  相似文献   

大负荷运动及恢复期大鼠心肌超微结构及心肌营养素-1的变化     

潘同斌  王雅一  左伟  唐芳 《北京体育大学学报》2012,35(12):53-56

摘要：目的：研究短期力竭运动及其恢复期间大鼠心肌超微结构及心肌营养素-1的变化。方法：8周龄健康雄性大鼠36只为研究对象,将其随即分为安静对照组(C)、力竭运动后即刻(Exhaustive,E0)、后12h组(E12)、后24h组(E24)、后48h组(E48)、后72h(E72)6组,每组6只。各运动组分别进行为期一周的力竭运动,安静对照组和力竭运动组分别于安静状态和末次力竭运动后不同时间点宰杀,迅速采取心肌样本,电镜观察大鼠心肌超微结构的变化,采用ELISA酶联免疫吸附反应法检测大鼠心肌营养素-1。结果：力竭运动后及恢复期心肌超微形态结构发生了不同程度的改变,其中以E0组和E24组较明显,心肌肌原纤维紊乱、扭曲,局部线粒体数量减少,甚至出现膨胀和变形。另一方面,大鼠在进行一周的大负荷运动后,心肌中的心肌营养素-1含量发生变化,力竭运动组(E0、E12、E24、E48、E72)与安静对照组相比都有显著性升高(P<0.01);其中,心肌营养素-1在E0组表达最显著,E72组有所回落(P<0.01)。结论：大负荷运动后及恢复期间,大鼠心肌内部结构遭到一定程度的破坏,同时大鼠心肌中的心肌营养素-1含量明显提高,且在E0组表达最高,提示大鼠心肌营养素-1在心肌损伤的修复中可能发挥重要作用。  相似文献   

音乐在PCI术后早期急性心肌梗死患者中的应用     

杨黎  黄惠根  吴兰笛  周英  王娇艳 《科技通报》2012,28(2):32-33

目的:探讨音乐应用于PCI术后早期急性心肌梗死患者的作用,促进患者康复.方法:便利抽样100名PCI术后AMI患者,分对照组和音乐组各50例,采用《HAD》和《AIS》调查并记录患者实验前后血压、心率、呼吸.结果:音乐组患者焦虑、睡眠质量、血压、心率、呼吸得分差值下降多于对照组,但抑郁得分较对照组高(P＜0.05).结论:音乐可缓解患者的焦虑,提高睡眠质量,维持血压、心率、呼吸处于相对较低水平.但音乐可释放抑郁情绪,应注意心理护理.  相似文献   

乙醇对离体蟾蜍心脏活动及心肌酶的影响     

崔淑芹  刘淑萍  程秀臻 《潍坊教育学院学报》2009,(2):90-91

目的观察不同浓度乙醇按不同灌流顺序对离体蟾蜍心脏活动的影响,探讨其作用机制。方法蟾蜍24只,雌雄不限,随机分为正常对照组、乙醇浓度递增灌流组、乙醇浓度递减灌流组,每组8只。结果与正常对照组相比：两种灌流顺序的乙醇组都显示心率减慢（P〈0.01或P〈0．05）,心肌收缩幅度减小（P〈0．01）,心肌ATP酶和超氧化物歧化酶（SOD）含量减少（P〈0．01）,丙二醛（MDA）含量增多（p〈0．01）;递增组与递减组相比,无显著差异。结论急性乙醇中毒可导致离体蟾蜍心肌酶发生改变,对心率和心肌收缩幅度有抑制作用,且抑制作用呈浓度依赖性.  相似文献   

Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome     

Cubranic Z  Madzar Z  Matijevic S  Dvornik S  Fisic E  Tomulic V  Kunisek J  Laskarin G  Kardum I  Zaputovic L 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(2):225-236

Introduction:

This study aimed to assess whether heart fatty acid-binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) could be used for the accurate diagnosis of acute myocardial infarction (AMI) in acute coronary syndrome (ACS) patients.

Materials and methods:

The study included 108 ACS patients admitted to a coronary unit within 3 h after chest pain onset. AMI was distinguished from unstable angina (UA) using a classical cardiac troponin I (cTnI) assay. H-FABP and GPBB were measured by ELISA on admission (0 h) and at 3, 6, 12, and 24 h after admission; their accuracy to diagnose AMI was assessed using statistical methods.

Results:

From 92 patients with ACS; 71 had AMI. H-FABP and GPBB had higher peak value after 3 h from admission than cTnI (P = 0.001). Both markers normalized at 24 h. The area under the receiver operating characteristic curves was significantly greater for both markers in AMI patients than in UA patients at all time points tested, including admission (P < 0.001). At admission, the H-FABP (37%) and GPBB (40%) sensitivities were relatively low. They increased at 3 and 6 h after admission for both markers and decreased again after 24 h. It was 40% for H-FABP and approximately 2-times lower for GPBB (P < 0.01). In AMI patients, both biomarkers had similar specificities, positive- and negative-predictive values, positive and negative likelihood ratios, and risk ratios for AIM.

Conclusion:

H-FABP and GPBB can contribute to early AMI diagnosis and can distinguish AMI from UA.  相似文献   

Role of l-Arginine on Dyslipidemic Conditions of Acute Myocardial Infarction Patients     

Pratima Tripathi  M. K. Misra  Shivani Pandey 《Indian journal of clinical biochemistry : IJCB》2012,27(3):296-299

Oxidative stress conditions associated with atherosclerosis leads to oxidative modification of low-density lipoprotein (LDL). The body’s capabilities to inhibit LDL oxidation and to remove or neutralize the atherogenic oxidized LDL (ox-LDL) are limited. When the LDL cholesterol level increases in the blood, it leads to dangerous consequences like atherosclerosis, leading to myocardial infarction. The major effect of an antioxidant in the LDL environment is to prevent the formation of ox-LDL (during atherogenesis. Strategies to reduce LDL oxidation and prevent atherogenesis can involve the enrichment of arterial cells with potent antioxidants that can prevent oxidative damage to the arterial wall. The objective of this study is to evaluate the effect of l-arginine on serum lipid and cholesterol levels in the patients of acute myocardial infarction (AMI). The study consisted of 70 AMI patients and 60 healthy individuals (serving as control) age 55–65 years. Serum levels of total cholesterol, high density lipoprotein (HDL), LDL and Triglycerides were determined on day 1 and day 15 of l-arginine administration (oral dose 3 g/day). The total cholesterol/HDL and the LDL/HDL ratio were calculated and compared. As per the observations, l-arginine administration was found to improve the lipid profile of the subjects. Hence it could be used as an adjuvant therapy for AMI and as a preventive measure for the onset of the disease in the healthy elderly also.  相似文献