不同运动强度对大鼠肾小管钠离子依赖性枸橼酸转运蛋白基因表达作用的研究     

吴丽霞  曹建民  郭林  李海河  高连峰 《北京体育大学学报》2004,27(3):339-340

观察分析在不同的运动强度诱导的"运动性酸中毒"环境中,大鼠肾小管上皮细胞刷状缘侧膜钠离子依赖性枸橼酸转运蛋白mRNA表达量的变化.结果表明:不同运动强度对枸橼酸转蛋白mRNA表达量的作用不一.A组运动强度较小,血乳酸的水平相对于对照组无显著性升高(P>0.05),转运蛋白mRNA表达量也无显著性差异(P>0.05).B组和C组运动强度较大,血乳酸水平相对于对照组显著性升高(P>0.05),转运蛋白mRNA表达量也呈现明显增加(P<0.05).C组较B组血乳酸水平显著性升高(P<0.05),但两组转运蛋白mRNA表达量却无显著性差异(P>0.05),提示可能存在酸碱度变化对转运蛋白mRNA表达量影响作用的阈值.  相似文献   

AMINO ACIDS' PROTECTIVE EFFECTS ON EXPERIMENTAL ACUTE RENAL FAILURE     

谢立平 《Journal of Zhejiang University. Science. B》2000,(2)

ＩＮＴＲＯＤＵＣＴＩＯＮＡｃｕｔｅｒｅｎａｌｆａｉｌｕｒｅ(ＡＲＦ),ｕｓｕａｌｌｙｒｅｆｅｒｒｅｄｔｏａｓａｃｕｔｅｔｕｂｕｌａｒｎｅｃｒｏｓｉｓ,ｉｓａｃｏｍｍｏｎｓｙｎｄｒｏｍｅｃｈａｒａｃｔｅｒｉｚｅｄｂｙａｎａｂｒｕｐｔａｎｄｓｕｓｔａｉｎｅｄｄｅｃｌｉｎｅｉｎｇｌｏｍｅｒｕｌａｒｆｉｌｔｒａｔｉｏｎｗｉｔｈｒｅｓｕｌｔａｎｔａｚｏｔｅｍｉａ,ｃａｕｓｅｄｂｙａｃｕｔｅｉｓｃｈｅｍｉｃａｎｄ/ｏｒｔｏｘｉｃｉｎｊｕｒｉｅｓ.Ｉｔｉｓｎｏｔｉｍｍｅｄｉａｔｅｌｙｒｅｖｅｒｓｉｂｌｅｗｈｅｎｃａ…  相似文献   

Exercise and inflammation in coronary artery disease: A systematic review and meta-analysis of randomised trials     

Gareth Thompson  Gareth W. Davison  Jacqui Crawford 《Journal of sports sciences》2020,38(7):814-826

ABSTRACT

Current evidence suggests that chronic inflammation contributes to the development of coronary artery disease (CAD). Interestingly, exercise may constitute a method of reducing inflammation in this patient population. As such, this systematic review and meta-analysis examined the evidence generated by randomised studies that investigated the effect of exercise on inflammatory biomarkers in CAD. Literature was sought from various sources. Outcomes were pooled in a random-effects model to calculate standardised mean differences (SMD) with 95% confidence intervals (CI). Twenty-five studies were reviewed; post-intervention C-reactive protein (SMD: ?0.55 (95% CI: ?0.93, ?0.16), P = 0.005), fibrinogen (SMD: ?0.52 (95% CI: ?0.74, ?0.29, P = <0.00001)), and von Willebrand factor (SMD: ?1.57 (95% CI: ?2.23, ?0.92), P = <0.00001) values were significantly lower in exercise groups compared to controls. In addition, qualitative analyses identified evidence that supports a beneficial effect of exercise on these acute-phase reactants. However, the impact of exercise on anti–inflammatory cytokines, adhesion molecules, and chemokines is equivocal, which may be attributed to a paucity of research. Nevertheless, the findings of this review suggest that exercise induces an anti–inflammatory effect in CAD patients. Although, the quality of evidence needs to be improved by further randomised studies with high methodological qualities and large sample sizes.  相似文献   

GSK3在抑郁症发病机制中的研究进展     

陈姣  ;楚世峰  ;王真真  ;陈乃宏 《河北北方学院学报(医学版)》2014,(5):44-54

尽管锂制剂在临床上使用了几十年,但其确切机制并不清楚。人们通过研究认识到锂可能是通过抑制糖原合成酶激酶3（glycogen synthase kinase 3,GSK3）而发挥抗抑郁作用的。锂可以调控GSK3下游的许多分子,许多抗抑郁类药物可以调控GSK3的信号。使用药理方法或基因沉默方法抑制GSK3均具有稳定情绪、抵抗抑郁的作用,这些研究表明GSK3可能是抗抑郁的潜在靶点。近些年来对GSK3在神经生物学中的作用机制的研究进一步证实了锂可能是通过作用于GSK3来达到治疗目的的。如GSK3可以调节生物体应激反应、炎症反应、神经发生、5-羟色胺（5-hydroxytryptamin,5-HT）传递过程,并参与生物周期节律的调控。因此,特异的GSK3抑制剂能否在临床上发挥抗抑郁作用有待进一步研究。该文对GSK3在应激反应、炎症反应、神经发生、5-HT传递过程以及生物周期节律这五个方面对抑郁发病机制的研究进行了综述。  相似文献   

Visceral and somatic hypersensitivity,autonomic cardiovascular dysfunction and low-grade inflammation in a subset of irritable bowel syndrome patients     

Liang Liu  Bei-ni Liu  Shuo Chen  Miao Wang  Yang Liu  Yan-li Zhang  Shu-kun Yao 《Journal of Zhejiang University. Science. B》2014,15(10):907-914

The pathophysiology of irritable bowel syndrome (IBS) is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction, and low-grade inflammation of the gut wall are associated with diarrhea-predominant IBS (D-IBS). Sixty-two patients with D-IBS and 20 control subjects participated in the study. Using the ascending method of limits (AML) protocol, we demonstrated that D-IBS patients had significantly lower sensory thresholds compared with healthy controls (P<0.001). Using diverse methods, especially the ischemic sensitivity test, for the first time in China, we confirmed that D-IBS patients have somatic hypersensitivity. They had a significantly higher systolic blood pressure and heart rate after a cold stimulus, indicative of autonomic cardiovascular dysfunction. Compared with the control group, D-IBS patients had a significantly higher level of calprotectin (P<0.001). We also found significant correlations between visceral and somatic hypersensitivity, visceral hypersensitivity and autonomic cardiovascular dysfunction, and somatic hypersensitivity and autonomic cardiovascular dysfunction. Our findings may provide valuable suggestions for the treatment of D-IBS.  相似文献   

2014年“第61届美国运动医学会年会”专栏：慢性持续性低度炎症与运动、健康和疾病的研究进展     

章岚  陈勇 《北京体育大学学报》2014,37(8):71-76

摘要：背景：研究表明慢性低度炎症在多数非传染性疾病的发病中起着关键作用,2014年ACSM年会把炎症在运动、健康和疾病中的作用作为热点专题。目的：探讨运动、营养、衰老、脂肪和骨骼肌与慢性炎症的关联。方法：分析归纳目前本方向年会的热点研究结果及进展。结果与结论：1.衰老及不良生活方式是慢性低度炎症的重要致炎因素;2.急性运动可促进产生炎症因子,规律运动可以减低炎性标志物;3.运动能降低骨骼肌慢性炎症;4.运动能降低脂肪组织的慢性炎症; 5.规律运动是降低年龄相关的慢性炎症反应的一种手段;6.营养补给对急性运动诱导的炎性反应的干预效果有待进一步研究。本年会的研究表明运动的抗炎作用可能是其降低慢性低度炎性疾病发生的重要机制。  相似文献   

两组慢性肾功能衰竭患者的营养咨询效果比较     

应晓维  吴金土 《宜春学院学报》2001,(2)

目的 :探讨慢性肾功能衰竭患者的营养咨询最佳方式 .方法 :对 30例农村组和 2 5例城市组的慢性肾功能衰竭病人给予营养咨询 1年 ,检测咨询前后的体重、血红蛋白、血白蛋白、血肌酐和尿素氮的变化 .结果 :(1)农村组患者的营养状况和肾功能减退程度与城市组有统计学意义 (P <0 0 1) .(2 )农村组患者优质蛋白质摄入比例严重不足 ,与城市组比较有统计学意义 (P <0 0 0 1) .结论 :患者的文化程度和经济状况对营养治疗的实施有直接影响 ,对不同对象患者营养指导的重点应有所不同  相似文献   

Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study     

Zhu  Huiyuan  Yan  Shaochun  Wu  Jingshuo  Zhang  Zhong  Li  Xiaolin  Liu  Zheng  Ma  Xing  Zhou  Lina  Zhang  Lin  Feng  Mingming  Geng  Yiwei  Zhang  Aixin  Janciauskiene  Sabina  Xu  Aiguo 《Journal of Zhejiang University. Science. B》2021,22(6):512-520

Background: Previous studies have shown that macrophage migration inhibitory factor(MIF) is involved in the pathogenesis of asthma. This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods: We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls, analyzing the parameter levels of serum MIF, serum total immunoglobulin E(tIgE), peripheral blood eosinophil percentage(EOS%), and fractional exhaled nitric oxide(FeNO). Lung function indices were used to identify disease severity and therapeutic response.Results: Our study showed that all measured parameters in patients were at higher levels than those of controls. After one week of treatment, most parameter levels decreased significantly except for serum tIgE. Furthermore, we found that serum MIF positively correlated with EOS% as well as FeNO, but negatively correlated with lung function indices. Receiver operator characteristic(ROC) curve analysis indicated that among the parameters, serum MIF exhibited a higher capacity to evaluate therapeutic response. The area under the curve(AUC) of MIF was 0.931, with a sensitivity of 0.967 and a specificity of 0.800.Conclusions: Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations.  相似文献   

中药热奄包治疗慢性盆腔炎的护理体会     

乔增凤  龚干珍 《大众科技》2016,(5):61-62

目的:总结中药热奄包治疗慢性盆腔炎的护理体会。方法:将加有跌打酊蒸热后的中药热奄包对慢性盆腔炎患者进行治疗,每次30分钟,每天一次,一个疗程10次,连续2个疗程后,观察疗效。结果:治疗组总有效率达83.4%,与对照组总有效率比较,P0.05。结论:中药热奄包治疗慢性盆腔炎,疗效确切,简单方便,患者无痛苦。  相似文献   

32例肾囊肿的X线和B超分析     

何乐林 《科技通报》1994,10(4):251-253

对３２例肾囊肿做了Ｘ线和Ｂ超分析．显示尿路平片可见肾外形的改变，静脉尿路造影表现出肾盂、肾盏移位、变形的各种形态．并探讨了其形成的机理．通过Ｘ线检查７例肾囊肿误为正常或肾癌，分析造成误诊的原因。Ｂ超检查显示边界清楚的圆形或椭圆形无回声液性暗区，其中仅１例将肾囊肿误诊为肾积水，诊断符合率为９７％（３１／３２）．因此，临床上颖有肾囊肿的影象检查应首选Ｂ超检查，Ｘ线检查能显示肾解剖结构和轮廓，提高对本病的诊断率，并讨论了ＣＴ对肾囊肿诊断的价值。  相似文献