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111.
当前,文科高校学报质量低的突出表现是栏目雷同化和大杂烩化,没有能够体现本校学科优势和地域特色的个性化栏目,解决存在问题的途径有两条:一是实施专题化和特色化;二是建立高质量的稿源。 相似文献
112.
113.
Basic fibroblast growth factor alleviates brain injury following global ischemia reperfusion in rabbits 总被引:9,自引:0,他引:9
Zhang M Ma YF Gan JX Jiang GY Xu SX Tao XL Hong A Li JK 《Journal of Zhejiang University. Science. B》2005,6(7):637-643
The aim of this study was to explore the protective effect of basic fibroblast growth factor (bFGF) on brain injury following global ischemia reperfusion and its mechanisms. Brain injury following global ischemia was induced by four vessels occlusion and systemic hypotension. Twenty-four rabbits were randomized into three groups: group A, only dissection of vessels; group B, intravenous infusion of normal saline after reperfusion for 6 h; group C, 30 μg/kg bFGF injected intravenously at the onset of reperfusion, then infused with 10 μg/(kg·h) for 6 h. Serum neuron specific enolase (NSE), S-100B, tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1), interleukin-8 (IL-8) were measured before ischemia, 30 min after ischemia, 0.5, 1, 3, 6 h after reperfusion. Brain water content was determined and cerebral histopathological damages were compared. NSE and S-100B were increased 1 h after reperfusion and reached their peaks 6 h after reperfusion, but were much higher in group B than those in group C 3, 6 h after reperfusion. In groups B and C, TNF-a was increased after ischemia and IL-1 and IL-8 were increased significantly 0.5 h after reperfusion, then reached their peaks 6 h, 3 h, 6 h after reperfusion respectively. TNF-a and IL-8 at the time points of 1 h and 3 h and IL-1 at 3 h and 6 h in group C were correspondingly lower than those in group B. These indices in group A were nearly unchanged. There were less severe cerebral histopathological damages in group C compared with group B, but no difference in brain water content. It could be concluded that bFGF alleviates brain injury following global ischemia and reperfusion by down-regulating expression of inflammatory factors and inhibiting their activities. 相似文献
114.
Use and effects of liver specific antigen in orthotopic liver transplantations were researched in this study. Group I: syngeneic
control (Wistar-to-Wistar); Group II: acute rejection (SD-to-Wistar); Group III: Thymic inoculation of SD rat LSA day 7 before
transplantation. The observation of common situation and survival time, rejection grades, NF-κB activity of splenocytes and
IL-2mRNA expression of grafted liver were used to analyze acute rejection severity and immune state of animals in different
groups. The common situation of group I was very well after transplantation and no signs of rejection were found. Recipients
of group II lost body weight progressively All dead within day 9 to day 13 posttransplantation; median survival time was 10.7
±0.51 days. It was an optimal acute rejection control. As for group III, 5 out of 6 recipients survived for a long time and
common situation was remarkably better than that of group II. Its rejection grades were significantly lower than that of group
II(P<0.05). NF-κB activity was only detected in group I at day 5 and day 7 after transplantation, whereas high activity of NF-κB
was detected at all time points in groupII and the low NF-κB activity detected in group III was significantly lower than that
of group II (P<0.05). No IL-2mRNA expression was detected at any time point in group I, whereas high level expression was detected at all
time points in group II and the low level expression only detected at day 3 in group III was significantly lower than that
of group II (P<0.05). Conclusion: LSA is an important transplantation antigen which is involved directly in the immunorejection of liver
transplantation. We report here for the first time that intrathymic inoculation of LSA can alleviate the rejection of liver
allotransplantation; and that grafts can survive for a long time thereby, thus leading to a novel way to achieve liver transplantation
immunotolerance.
Project (NO. 011106206) supported by the Science and Technology Bureau of Zhejiang Province Foundation 相似文献
115.
论述了一般含意和特殊含意在会话中的语用问题,目的是通过Grice的会话含意理论及其合作原则的推导,找到一般含意和特殊含意在含意理解和使用方面的普遍性规律,从而建立起一些对言语现象具有语用解释能力的原则和方法。 相似文献
116.
口语语料库的出现为英语口语教学提供了一种崭新的辅助手段,但通用口语语料库由于自身可及性和数据冗余等原因难以和口语教学实践相结合。本文从语境的角度探讨个人专题口语语料库的优势,指出这种小型教学语料库比通用口语语料库更容易融入日常口语教学工作。 相似文献
117.
王玉林 《邵阳学院学报(社会科学版)》2005,4(1):115-117
韩少功对语言有着深入的研究与思考,从《马桥词典》到《暗示》,韩少功对语言的认识经历了两次转向,《马桥词典》顺应了西方的“语言学转向”,而《暗示》则是这种转向的反动,走向了“否定之否定”。 相似文献
118.
Expressive reading is considered one of the subprocesses involved in reading fluency, and good readers show greater changes in tone and fewer unnecessary pauses than bad ones. Given the high frequency of reading difficulties in specific language impairment (SLI), there may be certain differences in the use of prosody among children with SLI. The purpose of this study was to research whether prosody in the reading of children with Spanish SLI differs from that in the reading of typical readers. To do so, 44 children (SLI and control) read aloud a text which contained declarative, interrogative and exclamatory sentences. Different prosodic parameters referring to length, tone and intensity were measured. The results showed that the children with SLI read slower, commit more errors and make more inappropriate pauses. Furthermore, fewer pitch variations were found in the interrogative sentence and in the final features of the sentence. These results confirm the relationship between decoding and prosody; therefore, interventions with these children should bear in mind the practice of expressive reading while learning reading fluency. 相似文献
119.
刘继岳 《北京师范大学学报(社会科学版)》2001,(5):99-105
生活实践和哲学理论都表明 :“粉笔是物质”这种命题是成立的。马克思主义哲学认为 ,任何事物都是个别和一般的对立统一 ,人的认识中的个别和一般的关系乃是客观事物中的个别和一般的关系之反映。个别和一般的关系在客观事物中表现为 :现象和本质的关系 ;个体和类的关系。反映在人的认识中则相应地表现为 :感性认识和理性认识的关系 ;个别概念和一般概念的关系。人们习惯地把这些关系看作是现实具体与思维抽象的关系。要坚持个别和一般关系的辩证观点 ,就必须批判经验论和唯理论 相似文献
120.
李达琳 《海南师范大学学报(社会科学版)》2002,15(3):127-129
良好的课堂氛围能使学生精神振奋、思维活跃,容易触发联想,在知识上形成新的联系。学生、教师和作者情感相通,思路一致,便能达到“同形同构”的最佳境界。从创造特定情境、发掘美感因素等教学目标出发,我们应强化教学的方法观念,积极引导学生“入境”、“入趣”和“入戏”,从而创造出良好的课堂氛围。 相似文献