The role of school-based research champions in a school–university partnership     

Katharine Burn  Robin Conway  Anne Edwards  Eluned Harries 《British Educational Research Journal》2021,47(3):616-633

The value of teachers’ engagement in and with research is long recognised and it is acknowledged that school–university research partnerships are one way of enabling such engagement. But we know little about how research-based knowledge is negotiated into school practices. Here we draw on data from nine ‘research champions’, who are teachers in schools which are part of the Oxford Education Deanery, a research partnership with a university department. Taking a cultural/historical approach, the study examined the strategic intentions and actions in the activities of the champions as they negotiated research-based knowledge into their schools. Data comprised 59 completed templates that described what they did and why. Findings revealed differences between those with close links with senior leaders—who could take a whole-school approach—and those whose reach was restricted by their position in school practices. Nonetheless, all the champions carefully selected and targeted research in ways that reflected their knowledge of local contexts. The findings point to the need to incorporate the champion role into school systems and for universities to value the role as they develop their own research agenda.  相似文献   

The impact of alternative authentic assessment outcomes in Palestinian fourth grade math classrooms     

《Studies in Educational Evaluation》2021

Focusing on evaluating students’ performance in basic math classrooms, the researchers in this study examined the impact of alternative assessments on learning outcomes in fourth grade Palestinian classrooms. Representing a large sector of education in the Palestinian territories, fourth grade students were randomly selected to participate in the study in which they participated in various math instructional and assessment activities throughout multiple lessons and cycles. Alternative assessment approaches were used including student self- assessment, peer assessment, and teacher assessment in terms of three main achievement levels to measure the extent to which students learned the math concepts by recall and remembrance, ability to apply, and making inferences. Mixed Design ANOVA measures were used to analyze and interpret the results which showed significant trends and correlations across the four cycles of math instruction and indicated that alternative authentic assessment methods have had a positive impact on students’ learning and application of math. Implications for integrating authentic assessment measures as well as peer and self- assessments were drawn in light of the promising outcomes of augmenting student motivation and developing critical life-long skills.  相似文献   

基于FPGA技术的8B/10B信道编码设计     

郑红党  孙彦景  李松  刘辉 《实验技术与管理》2021,(3):40-44

该文在分析8B/10B编码原理的基础上,设计了改进型8B/10B编码方案。该编码在完成高速数据信道编码功能的同时,可另外提供一路实时低速信道。基于FPGA技术采用查表法实现了改进型编解码电路,通过仿真验证了该编码方案的有效性,并在Spartan6系列FPGA中进行了综合测试。结果表明,此编解码方法占用的FPGA逻辑资源少,编解码速度可达到上百MB/s。  相似文献   

Attention‐Deficit/Hyperactivity Disorder Symptoms,Perceived Stress,and Resilience in College Students     

Stacey L. Hamilton  Amanda Baraldi  Shelia M. Kennison 《Journal of College Counseling》2021,24(1):49-62

This research investigated the relationships among symptoms associated with attention‐deficit/hyperactivity disorder (ADHD), perceived stress, and resilience in college students. In our study of 558 college students (175 men, 383 women), we confirmed the hypothesis that the relationship between ADHD symptoms and perceived stress is mediated by protective factors associated with resilience. The relationships were not significantly moderated by sex. Implications for increasing resilience in college students and lowering perceived stress for college students are discussed.  相似文献   

CHOP及GRP78在复发性多形性胶质母细胞瘤患者表达显著增加     

文雪 《孝感职业技术学院学报》2021,(1):108-112

目的:研究CHOP及GRP78与复发性GBM的相关性。方法:采用Western blot检测CHOP及GRP78在初发及复发GBM组织中的表达;Real-time PCR检测GRP78在初发以及复发GBM组织中的表达。结果:CHOP及GRP78在初发GBM中表达上调,而在经过原发性肿瘤切除后接受放疗和替莫唑胺化疗的复发性GBM中增加尤为显著。结论:CHOP及GRP78在GBM发病机制中起重要作用,该分子有望成为GMB潜在的诊断及预后评估标志物。  相似文献   

CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement     

Li  Chao  Brant  Eleanor  Budak  Hikmet  Zhang  Baohong 《Journal of Zhejiang University. Science. B》2021,22(4):253-284

Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010 s,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas) has rapidly been developed into a robust, multifunctional genome editing tool with many uses. Following the discovery of the initial CRISPR/Cas-based system, the technology has been advanced to facilitate a multitude of different functions. These include development as a base editor, prime editor, epigenetic editor, and CRISPR interference(CRISPRi) and CRISPR activator(CRISPRa) gene regulators. It can also be used for chromatin and RNA targeting and imaging. Its applications have proved revolutionary across numerous biological fields, especially in biomedical and agricultural improvement. As a diagnostic tool, CRISPR has been developed to aid the detection and screening of both human and plant diseases, and has even been applied during the current coronavirus disease 2019(COVID-19) pandemic. CRISPR/Cas is also being trialed as a new form of gene therapy for treating various human diseases, including cancers, and has aided drug development. In terms of agricultural breeding, precise targeting of biological pathways via CRISPR/Cas has been key to regulating molecular biosynthesis and allowing modification of proteins, starch, oil, and other functional components for crop improvement. Adding to this, CRISPR/Cas has been shown capable of significantly enhancing both plant tolerance to environmental stresses and overall crop yield via the targeting of various agronomically important gene regulators. Looking to the future, increasing the efficiency and precision of CRISPR/Cas delivery systems and limiting off-target activity are two major challenges for wider application of the technology. This review provides an in-depth overview of current CRISPR development, including the advantages and disadvantages of the technology,recent applications, and future considerations.  相似文献   

Osteogenic effects of antihypertensive drug benidipine on mouse MC3T3-E1 cells in vitro     

Wang  Baixiang  Yang  Jiakang  Fan  Lijie  Wang  Yu  Zhang  Chenqiu  Wang  Huiming 《Journal of Zhejiang University. Science. B》2021,22(5):410-420

Hypertension is a prevalent systemic disease in the elderly, who can suffer from several pathological skeletal conditions simultaneously, including osteoporosis. Benidipine(BD), which is widely used to treat hypertension, has been proved to have a beneficial effect on bone metabolism. In order to confirm the osteogenic effects of BD, we investigated its osteogenic function using mouse MC3 T3-E1 preosteoblast cells in vitro. The proliferative ability of MC3 T3-E1 cells was significantly associated with the concentration of BD, as measured by methylthiazolyldiphenyl-tetrazolium bromide(MTT)assay and cell cycle assay. With BD treatment, the osteogenic differentiation and maturation of MC3 T3-E1 cells were increased,as established by the alkaline phosphatase(ALP) activity test, matrix mineralized nodules formation, osteogenic genetic test,and protein expression analyses. Moreover, our data showed that the BMP2/Smad pathway could be the partial mechanism for the promotion of osteogenesis by BD, while BD might suppress the possible function of osteoclasts through the OPG/RANKL/RANK(receptor activator of nuclear factor-κB(NF-κB)) pathway. The hypothesis that BD bears a considerable potential in further research on its dual therapeutic effect on hypertensive patients with poor skeletal conditions was proved within the limitations of the present study.  相似文献   

中国四省市学生ICT胜任力的表现及影响因素——基于PISA 2015 ICT精熟度问卷数据的分析     

宋晓娟 《教育测量与评价(理论版)》2021,(2):14-20

信息素养是学生生存和发展的基本素养,对信息通信技术(ICT)的胜任力是反映学生信息素养的重要指标。基于PISA 2015中的ICT精熟度问卷数据,对中国四省市学生的ICT胜任力表现进行分析,考查中国学生的ICT资源、ICT使用情况以及ICT兴趣对其ICT胜任力的影响。结果发现:中国四省市学生的ICT胜任力在参测的48个国家和地区中排名靠后;不同性别、不同年级学生的ICT胜任力存在显著差异;家庭ICT资源对学生ICT胜任力有显著的正向预测作用;学生在学校使用ICT越多、在家使用ICT做作业越多,学生的ICT胜任力越高;学生的ICT兴趣越高,他们的ICT胜任力越高,学生的ICT兴趣对他们的ICT胜任力影响最大。为了提高我国学生的ICT胜任力,教育行政部门、学校、教师应充分重视ICT教育,完善ICT素养测评体系;扩大对ICT资源的投入,为学生更多地接触电子设备提供条件;加大ICT和电子设备的使用频率,在教育实践中逐步融入信息素养教育;着力培养学生对信息技术的兴趣,提高他们的ICT胜任力。  相似文献   

网络环境下有效学习行为特征及影响因素研究     

黄家荣  曹榴 《教育与教学研究》2021,(4):41-52

在网络环境下,学习者由于高度自由同时又缺乏有效的监管,学习很容易受到外界事件的干扰,并不能完全保证学习者的学习行为是有效的。为保证网络环境下学习的质量与绩效,有必要对网络环境下的有效学习行为进行深入研究。文章在“有效学习”定义基础上,提出网络环境下有效学习行为的概念及其特征,并详细讨论了网络环境下有效学习行为的主要影响因素,最后从中得到提高网络环境下学习行为有效性的启示:在课前,教师要做好学前分析,检查学习者是否已有本次学习必要的基础知识储备,并帮助学习者明确自己的学习目标,给学习者提供必要的学习环境;在课中,教师要注重学习者信息技术应用能力的培养,同时给学习者施加一定的外部动机,并结合具体情况,给予学习者有效的引导;在课后,教师需要及时对这节课进行反思总结。  相似文献   

中央信息管理与网络经济的宏观调控机制研究   总被引：4，自引：1，他引：4  

侯经川 《情报理论与实践》2005,28(1):13-17,47

在前期研究的基础上，本文探讨了构建中央信息库的必要性及其可能的构建方式与结构模型，设计了它对网络信息活动和网络经济运行的宏观调控机制。  相似文献