Gradual distraction with an external fixator is a widely used treatment for severe postburn ankle contracture (SPAC). However, application of external fixators is complex, and conventional two-dimensional (2D) imaging-based surgical planning is not particularly helpful due to a lack of spatial geometry. The purpose of this study was to evaluate the surgical planning process for this procedure with patient-specific three-dimension-printed models (3DPMs). In this study, patients coming from two centers were divided into two cohorts (3DPM group vs. control group) depending on whether a 3DPM was used for preoperative surgical planning. Operation duration, improvement in metatarsal-tibial angle (MTA), range of motion (ROM), the American Orthopedic Foot and Ankle Society (AOFAS) scores, complications, and patient-reported satisfaction were compared between two groups. The 3DPM group had significantly shorter operation duration than the control group ((2.0±0.3) h vs. (3.2± 0.3) h, P<0.01). MTA, ROM, and AOFAS scores between the two groups showed no significant differences pre-operation, after the removal of the external fixator, or at follow-up. Plantigrade feet were achieved and gait was substantially improved in all patients at the final follow-up. Pin-tract infections occurred in two patients (one in each group) during distraction and were treated with wound care and oral antibiotics. Patients in the 3DPM group reported higher satisfaction than those in the control group, owing to better patient-surgeon communication. Surgical planning using patient-specific 3DPMs significantly reduced operation duration and increased patient satisfaction, while providing similar improvements in ankle movement and function compared to traditional surgical planning for the correction of SPAC with external fixators.
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Li-na Han Shuang He Yu-tang Wang Li-ming Yang Si-yu Liu Ting Zhang 《Journal of Zhejiang University. Science. B》2013,14(8):676-687
Monoclonal antibodies have become a part of daily preparation technologies in many laboratories. Attempts have been made to apply monoclonal antibodies to open a new train of thought for clinical treatments of autoimmune diseases, inflammatory diseases, cancer, and other immune-associated diseases. This paper is a prospective review to anticipate that monoclonal antibody application in the treatment of myocarditis, an inflammatory disease of the heart, could be a novel approach in the future. In order to better understand the current state of the art in monoclonal antibody techniques and advance applications in myocarditis, we, through a significant amount of literature research both domestic and abroad, developed a systematic elaboration of monoclonal antibodies, pathogenesis of myocarditis, and application of monoclonal antibodies in myocarditis. This paper presents review of the literature of some therapeutic aspects of monoclonal antibodies in myocarditis and dilated cardiomyopathy to demonstrate the advance of monoclonal antibody application in myocarditis and a strong anticipation that monoclonal antibody application may supply an effective therapeutic approach to relieve the severity of myocarditis in the future. Under conventional therapy, myocarditis is typically associated with congestive heart failure as a progressive outcome, indicating the need for alternative therapeutic strategies to improve long-term results. Reviewing some therapeutic aspects of monoclonal antibodies in myocarditis, we recently found that monoclonal antibodies with high purity and strong specificity can accurately act on target and achieve definite progress in the treatment of viral myocarditis in rat model and may meet the need above. However, several issues remain. The technology on how to make a higher homologous and weak immunogenic humanized or human source antibody and the treatment mechanism of monoclonal antibodies may provide solutions for these open issues. If we are to further stimulate progress in the area of clinical decision support, we must continue to develop and refine our understanding and use of monoclonal antibodies in myocarditis. 相似文献
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通过对生化、血液、免疫等指标的实验研究,探讨八一铁人三项队女运动员在800m游泳训练考核后,机体发生的应激损伤情况。对八一铁人三项队9名女运动员,在安静状态、800m游泳考核后2h内、次日晨,分别抽取静脉血10ml,进行生化、血液、免疫等指标的测试,从而对运动员机体的应激损伤情况进行分析。生化指标ALT、AST、BU、CK等在800m游泳考核后升高明显,次日晨基本都能恢复至安静状态水平;血液指标RBC、HB、HCT在三次测试中次日晨最高,800m游泳考核后N升高、L降低,次日晨基本恢复;免疫指标800m游泳考核后CD3、CD4均有所升高,次日晨反而降低,800m游泳考核后CD19升高、CD56降低。八一铁人三项队女运动员,在800m游泳考核后2h内及次日晨,其生化、血液、免疫等部分指标发生变化,这些指标的波动,能对其机体应激损伤的评价,提供辅助与指导意义。 相似文献
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通过实验研究,发现在武警大负荷训练中持续服用1个月的军用耐力固体运动饮料,对血常规和细胞免疫没有显著性影响,但可提升大负荷训练期武警官兵的机能水平,从血糖指标来看,实验4周对照组血糖下降有显著性差异,而实验组没有表现出这种变化,表明该饮料补糖效果好且无胰岛素反应。反映训练量和负荷的指标血尿素和血清肌酸激酶训练次日晨的变化,实验纽升高的幅度低于对照组升高幅度,表明该饮料能有效对抗运动性疲劳的深度,能显著提升训练的效益。 相似文献
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Xing Tao Ling-qiao Lu Qing Xu Shu-ren Li Mao-tsun Lin 《Journal of Zhejiang University. Science. B》2009,10(10):740-747
Objective: We compare the cardioprotective effects of anesthetic preconditioning by propofol and/or isoflurane in rats with ischemia-reperfusion injury. Methods: Male adult Wistar rats were subjected to 60 min of anterior descending coronary artery occlusion followed by 120 min of reperfusion. Before the long ischemia, anesthetics were administered twice for 10 min followed by 5 min washout. Isoflurane was inhaled at I MAC (0.016) in I group, whereas propofol was inhaled intravenously at 37.5 mg/(kg.h) in P group. A combination ofisoflurane and propofol was administered simultaneously in I+P group. Results: In control (without anesthetic preconditioning, C group), remarkable myocardial infarction and apoptosis accompanied by an increased level of cardiac troponin T were noted 120 rain after ischemia-reperfusion. As compared to those of control group, I and P groups had comparable cardioprotection. In addition, I+P group shares with I and P groups the comparable cardioprotective effects in terms of myocardial infarction and cardiac troponin T elevation. Conclusion: A combination of isoflurane and propofol produced no ad-ditional cardioprotection. 相似文献
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中国基层党政领导干部的工作绩效结构 总被引：10，自引：1，他引：10
本研究旨在系统探讨党政领导干部工作绩效的结构。通过对94名党政领导干部的深度访谈，共收集到评估自我、下属和上级工作绩效的项目222个，并由2674名被试进行评定。经探索性因素和二阶因素分析，评定自我和下属工作绩效的结构相同。均为任务指向和个人品质两个维度，评定上级工作绩效时却出现了四个维度，但仍然可以划分为任务指向和个人素质两大类。而且，对个人素质和任务指向的重视程度在评定自我工作绩效时相同，在评定下属工作绩效时更重视任务指向特点，而评定上级工作绩效时则更看重个人素质。本研究的结果与西方关于工作绩效的“任务一关系绩效”模型存在明显的差异。文中从中西方文化差异的角度对结果进行了讨论，并提出了进一步研究的设想。 相似文献
38.
Lin J Xiang D Zhang JL Allickson J Xiang C 《Journal of Zhejiang University. Science. B》2011,12(5):372-380
Stem cells can be obtained from women’s menstrual blood derived from the endometrium. The cells display stem cell markers
such as Oct-4, SSEA-4, Nanog, and c-kit (CD117), and have the potent ability to differentiate into various cell types, including
the heart, nerve, bone, cartilage, and fat. There has been no evidence of teratoma, ectopic formation, or any immune response
after transplantation into an animal model. These cells quickly regenerate after menstruation and secrete many growth factors
to display recurrent angiogenesis. The plasticity and safety of the acquired cells have been demonstrated in many studies.
Menstrual blood-derived stem cells (MenSCs) provide an alternative source of adult stem cells for research and application
in regenerative medicine. Here we summarize the multipotent properties and the plasticities of MenSCs and other endometrial
stem cells from recent studies conducted both in vitro and in vivo. 相似文献
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Chen Youbai Niu Zehao Jiang Weiqian Tao Ran Lei Yonghong Guo Lingli Zhang Kexue Xia Wensen Song Baoqiang Huang Luyu Zhang Qixu Han Yan 《Journal of Zhejiang University. Science. B》2021,22(10):866-875
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目的:提高面向医务人员的精准医学伦理和社会学继续教育效果。医学继续教育担负着传播医学新技术、新知识的重任,在精准医学研究和医疗实践中间架起了一座桥梁,为医务人员的成长和进步提供了重要的条件。精准医学作为一种革命性的新技术,需要进行法律、伦理和社会问题的全新考量,并通过医学继续教育向医务人员进行普及。方法:总结本领域继续教育的现状,结合国际进展和经验,改进教育措施,进行验证。在常见的医学继续教育活动中,涉及精准医学伦理和社会学问题部分的内容往往较为陈旧、角度单一、论据空泛、重点不够突出。很有必要在医学继续教育中关注本领域的进展,引导医务人员针对这些精准医学相关的伦理和社会学问题进行归纳、分析和讨论,以降低医学实践的法律、伦理和社会风险,保护医患权益。结论:围绕精准医学的继续教育的伦理和社会学问题,基于我们的实践,通过不断充实继续教育的重点内容,切换理论角度,大大提高了医务人员精准医学继续教育活动的效果,助力医务人员应对医学技术革新的重大挑战。 相似文献
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