跑台运动通过p38信号上调FNDC5激活Akt改善Ⅱ型糖尿病小鼠认知功能障碍     

张蒙  吴双双  郭源  寇现娟 《武汉体育学院学报》2022,56(4):72-80

目的:探讨8周跑台运动对db/dbT2DM小鼠认知功能的影响及其分子机制。方法:24只8周龄db/dbT2DM小鼠和8只同龄对照m/m小鼠,将db/db小鼠随机分为:模型组(db/db)、运动干预组(db+Exe)、运动联合p38抑制剂组(db+Exe+SB203580)。db+Exe组进行8周跑台训练,db+Exe+SB203580组进行8周跑台运动联合SB203580抑制剂灌胃处理(5mg/kg,3d/W,8W)。每周定时检测小鼠的体重和空腹血糖;干预结束后,取全脑及海马组织,免疫组织化学染色观察海马不同区域的神经元损伤状态;Western Blot检测海马组织中AD样病理、神经炎症、突触可塑性、过氧化物酶体增殖物激活受体γ辅激活因子1α(PGC-1α)/Ⅲ型纤连蛋白组件包含蛋白5(FNDC5)、Akt激酶等蛋白的表达。结果显示:(1)跑台运动可明显改善db/db小鼠的认知功能障碍。(2)减轻db/db小鼠的海马神经元损伤。(3)降低海马内AD样病理、神经炎症蛋白的表达,增加突触蛋白的表达水平。(4)通过p38信号上调PGC-1α/FNDC5的表达。(5)跑台运动可激活Akt激酶,而p38抑制剂可降低跑台运动对Akt激酶的激活作用。结论:8周跑台运动可明显改善db/db小鼠的认知功能障碍,其机制可能是通过p38上调PGC-1α/FNDC5,激活Akt激酶,减弱AD病理进程,降低炎性反应,增加突触可塑性,改善其空间学习记忆能力。  相似文献   

802.11 MAC层协议分析     

孙吉泉  鞠艳 《中国科技信息》2009,(14):134-135

本文深入了分析802.11MAC子层协议,重点阐述并讨论MAC层结构,访问控制方式、信包重垫等,并对其发展趋势作了展望.  相似文献   

教育功能:诠释,梳理   总被引：1，自引：0，他引：1  

胡贵勇 《教育理论与实践》2003,(18)

正确理解教育功能是进一步认识“什么是教育”的关键。目前,我国教育功能研究中最具代表性的两种功能观是个体功能与社会功能观和教育的正、负功能观,前者对教育功能的研究缺乏层次性、动态性和内在统一性,后者则曲解了“功能”的本义,将“功能”与“作用”混同,因而应对教育功能问题的研究进行重新审视,对教育功能重新界定,从而对教育功能进行结构改造,让教育功能的讨论与研究回归到教育本真意义上去。  相似文献   

ERα promotes transcription of tumor suppressor gene ApoA-I by establishing H3K27ac-enriched chromatin microenvironment in breast cancer cells     

Bingjie WANG  Yinghui SHEN  Tianyu LIU  Li TAN 《Journal of Zhejiang University. Science. B》2021,22(12):1034

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Digital ITEMS Module 1: Reliability in Classical Test Theory          下载免费PDF全文

Charlie Lewis  Michael Chajewski  André A. Rupp 《Educational Measurement》2018,37(2):71-72

In this ITEMS module, we provide a two‐part introduction to the topic of reliability from the perspective of classical test theory (CTT). In the first part, which is directed primarily at beginning learners, we review and build on the content presented in the original didactic ITEMS article by Traub and Rowley (1991). Specifically, we discuss the notion of reliability as an intuitive everyday concept to lay the foundation for its formalization as a reliability coefficient via the basic CTT model. We then walk through the step‐by‐step computation of key reliability indices and discuss the data collection conditions under which each is most suitable. In the second part, which is directed primarily at intermediary learners, we present a distribution‐centered perspective on the same content. We discuss the associated assumptions of various CTT models ranging from parallel to congeneric, and review how these affect the choice of reliability statistics. Throughout the module, we use a customized Excel workbook with sample data and basic data manipulation functionalities to illustrate the computation of individual statistics and to allow for structured independent exploration. In addition, we provide quiz questions with diagnostic feedback as well as short videos that walk through sample exercises within the workbook.  相似文献   

Evaluation of Dimensionality in the Assessment of Internal Consistency Reliability: Coefficient Alpha and Omega Coefficients          下载免费PDF全文

Samuel B. Green  Yanyun Yang 《Educational Measurement》2015,34(4):14-20

In the lead article, Davenport, Davison, Liou, & Love demonstrate the relationship among homogeneity, internal consistency, and coefficient alpha, and also distinguish among them. These distinctions are important because too often coefficient alpha—a reliability coefficient—is interpreted as an index of homogeneity or internal consistency. We argue that factor analysis should be conducted before calculating internal consistency estimates of reliability. If factor analysis indicates the assumptions underlying coefficient alpha are met, then it can be reported as a reliability coefficient. However, to the extent that items are multidimensional, alternative internal consistency reliability coefficients should be computed based on the parameter estimates of the factor model. Assuming a bifactor model evidenced good fit, and the measure was designed to assess a single construct, omega hierarchical—the proportion of variance of the total scores due to the general factor—should be presented. Omega—the proportion of variance of the total scores due to all factors—also should be reported in that it represents a more traditional view of reliability, although it is computed within a factor analytic framework. By presenting both these coefficients and potentially other omega coefficients, the reliability results are less likely to be misinterpreted.  相似文献   

Infliximab treatment in two Chinese patients with psoriatic arthritis     

Xi Xie  Jin-wei Chen  Fen Li  Jing Tian  Jie-sheng Gao  David Zhang 《Journal of Zhejiang University. Science. B》2010,11(10):779-782

Psoriatic arthritis (PsA) is a rheumatoid factor (RF)-seronegative systemic inflammatory disorder associated with psoriasis. Current treatment for PsA in China is still focused on disease modifying anti-rheumatic drugs (DMARDs). In this paper, we report two Chinese patients with active longstanding PsA treated with infliximab, a human-mouse chimeric monoclonal antibody against tumor necrosis factor alpha (TNF-α). The results show that infliximab acted quickly and effectively in relieving peripheral and axial symptoms and refractory skin lesions, even in recombinant human TNF-α receptor (rhTNFR)-resistant case. The take-home message from our cases is that infliximab is a useful therapeutic option for refractory PsA, especially when a patient has a combination of psoriasis and psoriatic arthritis. Further local evidence and experience must be accumulated in order to make anti-TNF-α therapy more accessible to PsA patients in China.  相似文献   

The Prevalence Of β-Thalassemia Mutations in South Western Maharashtra     

Sandeep B. Satpute  Mangesh P. Bankar  Abdulrahaman A. Momin 《Indian journal of clinical biochemistry : IJCB》2012,27(4):389-393

Thalassemia has been recognized by the World Health Organization as important inherited disorders principally impacting on the populations of low income countries. In this report, the prevalence of common β-thalassemia mutations in India was defined in 126 β-thalassemia carrier subjects in a western Indian population mainly from the south-western Maharashtra. The six most common β-thalassemia mutations were detected, which included IVS I-5 (G–C), IVS I-1 (G–T), codon 8–9 (+G), codon 41/42 (–TCTT), Codon 15 (G–A), and 619 bp deletion at 3′ end of β-globin gene. These mutations accounted for 93.66 % in 126 β-thalassemia carrier subjects and 6.34 % remained uncharacterized. Out of 126, 82 (65.07 %) showed the most common (prevalent) type of mutation, IVS I-5 (G–C), followed by IVS I-1 (G–T) showed by 12 (9.52 %) subjects. Three (2.38 %) subjects showed 619 bp deletion, codon 8/9 (+G) and codon 15 (G–A) mutations were present in eight subjects each (6.34 %). Only five (3.96 %) subjects showed codon 41/42 (–TCTT). There were eight (6.34 %) subjects where mutation was not any of the six mutations studied. This study provides the pattern of β thalassemia mutations from south-western Maharashtra, which will help to prevent β-thalassemia using prenatal diagnosis and proper counseling.

Electronic supplementary material

The online version of this article (doi:10.1007/s12291-012-0230-y) contains supplementary material, which is available to authorized users.  相似文献   

Impact of Chronic Lead Exposure on Selected Biological Markers   总被引：1，自引：0，他引：1  

Ambica P. Jangid  P. J. John  D. Yadav  Sandhya Mishra  Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2012,27(1):83-89

Lead poisoning remains a major problem in India due to the lack of awareness of its ill effects among the clinical community. Blood lead, δ-aminolevulinic acid dehydratase (δ-ALAD) and zinc protoporphyrin (ZPP) concentrations are widely used as biomarkers for lead toxicity The present study was designed to determine the impact of chronic lead exposure on selected biological markers. A total of 250 subjects, of both sexes, ranging in age from 20 to 70 years, were recruited. On the basis of BLLs, the subjects were categorized into four groups: Group A (BLL: 0–10 μg/dl), Group B (BLL: 10–20 μg/dl). Group C (BLL: 20–30 μg/dl) and Group D (BLL: 30–40 μg/dl) having BLLs of 3.60 ± 2.71 μg/dl, 15.21 ± 2.65 μg/dl, 26.82 ± 2.53 μg/dl and 36.38 ± 2.83 μg/dl, respectively. Significant changes in biological markers due to elevated BLLs were noted. The relation of BLL and biological markers to demographic characteristics such as sex, habits, diet and substances abuse (smoking effect) were also studied in the present investigation. Males, urban population, non-vegetarians, and smokers had higher blood lead levels. δ-ALAD activity was found to be significantly lower with increased BLL (P < 0.001), while the ZPP level was significantly higher with increased BLL (P < 0.001). Further, BLL showed a negative correlation with δ-ALAD (r = −0.425, P < 0.001, N = 250) and a positive correlations with ZPP (r = 0.669, P < 0.001, N = 250). Chronic lead exposure affects the prooxidant-antioxidant equilibrium leading to cellular oxidative stress.  相似文献   

Ibn Baṭṭūṭa on Shedding of Blood in the Delhi Sultanate     

David Waines 《Al-Masaq: Islam & the Medieval Mediterranean》2012,24(3):279-292

Ibn Ba??ū?a's longest sojourn (734–748/1333-ca. 1347) in his famous world travels was in the domains of the Delhi sultanate ruled by Mu?ammad b. Tughluq. He presents a vivid picture of court life in Delhi and a portrait of the sultan, whom Ibn Ba??ū?a describes in contrasting terms of generosity and violence. This essay examines the latter phenomenon, first by briefly noting the contribution of two contrasting studies on the complex nature of violence itself (Part One), followed by Ibn Ba??ū?a's depiction of Ibn Tughluq's accession to power (Part Two), and then his perception of the sultan's use of capital punishment during his reign (Part Three). The last section (Part Four) adds further detail on the sultan's policy and then briefly compares Ibn Ba??ū?a's perception of the sultan's violence with that of another contemporary witness, the historian ?iyā? al-Dīn Baranī. The result suggests that Ibn Ba??ū?a's representation of violence is as nuanced as the phenomenon of violence itself.  相似文献