Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

基于TOPSIS改进Shapley值的邮轮公司与航空公司合作收益分配     

闵德权  赵琼  崔琪  刘茹 《上海海事大学学报》2020,41(3):73-81

为制定"邮轮+飞机"合作销售模式下邮轮公司与航空公司合理的收益分配方案,保持合作的稳定性和积极性,构建合作收益模型,求解最优合作收益。考虑风险和资源投入因素,构建基于改进Shapley值的收益分配模型,对最优合作收益进行公平、合理的分配;基于TOPSIS对收益分配方案进行综合优化,以此提供有效的解决方案。算例结果表明:优化后的方案考虑合作成员多方面的贡献,对投入较多的公司进行一定的补偿,具有可行性和公平性。  相似文献   

The balancing act of social enterprise: An IT emergence perspective     

《International Journal of Information Management》2021

The significance of IT in the context of non-digital social enterprises (SEs) and its influence on the viability of such SEs have been less studied themes in information systems research. In the era of ubiquitous IT, SEs have increasing pressures to cope with the ever-dynamic technological domain while balancing their dual objectives. Data from a single revelatory case of Jaipur Rugs (JR), an SE situated in a developing country context (India), is used to fathom the peculiarities of the SE context with a focus on the sociomaterial phenomena of IT emergence. Using the three fundamental notions of sociomateriality theory (relationality, performativity, and practice) this interpretive study understands the mechanisms underlying the SE’s attempt to balance its financial and social sustainability objectives. Through the innovative use of IT, the SE establishes and maintains shared value, yielding stability and efficiency to the business (financial viability) while simultaneously ensuring scalability and effectiveness of their social impact. This study strengthens the perspective of IT as an emergent phenomenon situated in sociomaterial practices and fills a gap in organizational literature by examining such phenomenon in the rich context of SEs where achieving the balance between dual goals is increasingly dependent on non-human (IT) agents.  相似文献   

电视新闻策划的实践思考     

夏冰 《浙江传媒学院学报》2003,10(3):18-20

新闻策划是对新闻报道活动的策划,电视新闻策划是现代社会受众和电视自身发展的需要。电视新闻的策划重在发挥电 视传播的优势,强调整体的协作。  相似文献   

对我国企业体育目前的现状、不足和发展趋势的研究   总被引：4，自引：0，他引：4  

郝小刚 《南京体育学院学报(社会科学版)》2003,17(2):44-45,30

通过分析我国目前企业体育在市场经济制度下存在的不足 ,找出原因。借鉴国外企业体育的发展过程 ,从而得知职工体育俱乐部是我国企业体育的必然发展趋势。  相似文献   

中国传统文化与学校体育可持续发展   总被引：2，自引：0，他引：2  

吴刚 《湖北体育科技》2003,22(2):156-157,160

中国传统文化是学校体育可持续发展的外环境因素，它主要由儒家、道家和禅宗文化构成，具有中庸和平、泛道德性、人文精神、非独立性、静止停滞、乡土情结等特质，通过研究它的理性因素对学校体育可持续发展的正面影响和非理性因素带来的负面影响，来探讨在学校体育思想、内容和方法上应采取的发展对策。  相似文献   

论体育赞助对赞助企业的影响   总被引：4，自引：0，他引：4  

李国岳 《广州体育学院学报》2003,23(5):23-24

体育赞助对体育和赞助企业来说是一种双赢的活动。本旨在通过分析体育赞助对赞助企业带来的积极影响，为体育赞助提供一定的理论依据。  相似文献   

GM(1,h)系统状态模型在田径训练中的应用   总被引：4，自引：0，他引：4  

刘嘉津  孙桂云 《上海体育学院学报》2003,27(1):78-81,F003

将多因素整体状态GM（1，h)模型及其特列GM（1，1）模型结合起来，用于高水平田径训练的建模问题研究，使建立的系统模型既能反映系统内部多因素的整体关系，又能满足超前预测和规划的需要，旨为田径训练提供了一种有效的科学方法。  相似文献   

电大生《经济数学基础》课程学习困难的成因分析   总被引：1，自引：0，他引：1  

潘红卫 《广西广播电视大学学报》2003,14(4)

本文对电大生《经济数学基础》课程学习困难的成因进行了分析,并对教师在该课程教学中要注意的问题提出了几点建议。  相似文献   

甘肃省中小学青年体育教师综合素质的调查研究     

王建民  谢芳  张永贵  盛建国  丁斌  唐广旭 《北京体育大学学报》2006,29(8):1105-1107

运用问卷调查法、数理统计法等对我省225名中小学青年体育教师的师德修养、文化素质、心理素质、科研能力和社会适应能力等方面进行了调查,对调查结果进行了分析讨论并提出了相应对策,为高师体育教育本科专业教育教学改革提供了依据和参考.  相似文献