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Objective: To investigate the directed transplantation of allograftic bone marrow-derived mesenchymal stem cells (MSCs) in myocardial infarcted (MI) model rabbits. Materials and Methods: Rabbits were divided into 3 groups, heart infarcted model with MSCs transplanted treatment (MSCs group, n=12), heart infarcted model with PBS injection (control group, n=20), sham operation with PBS injection (sham group, n=l 7). MSCs labelled by BrdUrd were injected into the MI area of the MSCs group. The same volume of PBS was injected into the MI area of the control group and sham group. The mortality, LVIDd, LVIDs and LVEF Of the two groups were compared 4 weeks later. Tropomyosin inhibitory component (Tn I) and BrdUrd immunohistochemistry identified the engrafted cells 4 weeks after transplantation. Result: The mortality of the MSCs group was 16.7% (2/12), and remarkably lower than the control group's mortality [35% (7/20) (P＜0.05)].Among the animals that survived for 4 weeks, the LVIDd and LVIDs of the MSCs group after operation were 1.17±0.21 cm and 0.74±0.13 cm, and remarkably lower than those of the model group, which were 1.64±0.14 cm and 1.19±0.12 cm (P＜0.05); the LVEF of the MSCs group after operation was 63±6%, and remarkably higher than that of the model group,which was 53±6% (P＜0.05). Among the 10 cases of animals that survived for 4 weeks in the MSCs group, in 8 cases (80%),the transplanted cells survived in the non MI, MI region and its periphery, and even farther away; part of them differentiated into cardiomyocytes; in 7 cases (70%), the transplanted cells participated in the formation of blood vessel tissue in the MI region. Conclusion: Transplanted allograftic MSCs can survive and differentiate into cardiomyocytes, form the blood vessels in the MI region. MSCs transplantation could improve the heart function after MI. 相似文献
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<正>学前教育是我国国民教育体系重要组成部分,对促进幼儿个体全面健康发展,全面提升国民整体素质具有重要的基础性、先导性的作用。随着国家经济实力的增强,《国家中长期教育改革和发展规划纲要》的实施,学前教育越来越受到人们的关注和重视。经济欠发达地区由于财力的限制,学前教育事业的发展也相对滞后,如何应对国家大力发展学前教育的战略机遇,促进经济欠发达地区的学前教育事业发展,只有找到发展中的突出矛盾和问题,提出 相似文献
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家用速热磁水淋浴器是利用燃气灶县、蜂窝煤炉、沼气或汽化油炉等各种热源迅速加热自来水，并经专用磁化器和麦饭石矿化片对水质进行磁化矿化后供家庭冼浴的最新普及型速热磁永淋浴装置。本产品结构新颖独特、小巧方便、使用安全可靠、经济耐用。产品符合我国国情，能适应不同层次的消费需要， 相似文献
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主动脉内气囊反搏的抗凝问题 总被引：2，自引：0，他引：2
目的 研究主动脉内气囊反搏(IABP)是否需要常规抗凝.方法 连续选择IABP病人153例,随机分组进入抗凝组(A组)71例,非抗凝组(B组)82例.抗凝组静脉给予肝素针维持aPTT于50～70s.非抗凝组无肝素针静脉维持.检测二组即刻,24h,48h以及IABP拔除后24h血小板计数,D 二聚体,纤溶酶原活化剂抑制物 1(PAI 1)和纤维蛋白降解产物(FDP)水平.观察IABP引起的肢体缺血或肢体出血等并发症、以及IABP表面的血栓情况.结果 抗凝组和非抗凝组的血小板计数和PAI 1水平于24h和48h均较本身的基础值显著下降(P<0.05).抗凝组和非抗凝组的D 二聚体和FDP水平于24h和48h均较本身的基础值显著升高(P<0.05).但二组间各个时段血小板计数,D 二聚体,PAI 1和FDP水平的比较均无显著性差异.抗凝组3例,非抗凝组2例发生一般肢体缺血.抗凝组2例大出血,8例一般出血;非抗凝组2例一般出血(P<0.05).IABP表面血栓二组均无发生.结论 IABP不需常规抗凝,抗凝不能预防IABP引起的肢体缺血.选择适当的导管经路和早期发现是预防并发症的关键. 相似文献
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INTRODUCTIONCoronaryarterydisease (CAD)continuestobethemajorcauseofmorbidityandmortalityinourcountry .TheactivityofbloodcoagulationfactorshasbeenshowntobeanimportantriskindicatorforCAD .However,circulatinglevelsofcoagulationfactorsmaynotaccuratelyreflectt… 相似文献
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技术创新与制度创新的匹配机制研究：—一个理论框架和两个案例分析 总被引：8，自引：0，他引：8
传统的经济增长理论不是只强调技术创新就是只强调制度创新的重要性，而本认为经济增长必须通过技术创新与制度创新的匹配才能实现。为了阐明这个观点，本首先对索洛1957年和诺斯1968年的论进行了重新解释，批评了早先从这两篇论中得出的技术决定论和制度决定论观点，然后在综合前人工作的基本上提出了一个关于技术创新与制度创新匹配机制的一般性理论框架；最后运用这个理论框架分析了两个案例。 相似文献
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教学论认为:任何教学内容都可以用一个问题呈现出来,学习的发生起源于情景变化的刺激,或叫作问题。将知识转化为问题情景,是在建构主义理论指导下演变的一种教学模式,也即情景教学模式。建构性 相似文献
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English writing is a complex integrative process of comprehensive skills.A host of students are still unable to write a coherent English paragraph after having learned English for many years at school.To help college students improve their writing competence is a great challenge facing the English teaching in China.Researches on writing teaching method abroad have experienced prosperity.In China,however,researches in this field are far behind.There is great need to search for more efficient writing instruction model so that it can serve well in Chinese context.Enlightened by Krashen’s input hypothesis and Swain’s output hypothesis,the writer put forward Reading-Based Writing Instruction Model.This paper aims to discuss the effectiveness of this model from the different perspectives. 相似文献