Carnosine in health and disease     

Guilherme Giannini Artioli  Craig Sale  Rebecca Louise Jones 《European Journal of Sport Science》2019,19(1):30-39

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.  相似文献   

Longitudinal Analyses of Academic Achievement     

Gary L. Williamson  Mark Appelbaum  Alex Epanchin 《Journal of Educational Measurement》1991,28(1):61-76

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Virtual and non‐virtual realities: the changing roles of libraries and librarians     

Alex C. Klugkist 《Learned Publishing》2001,14(3):197-204

What is the future for libraries and their librarians? In trying to give an answer to this pressing question we do not deal with utopian libraries of the next century, but with the library and the librarian of the next decade. The emphasis is on libraries within educational and research institutions, especially university libraries. We examine the changes confronting the library of the future and identify four key aspects of the library of the future. It will be (i) a gateway to information, whatever format this information comes in and wherever it is located; (ii) an expertise centre; (iii) a physical entity, not only in the sense of being a social meeting place and place of scholarly interaction, but also as a place where students and other users are provided with modern study facilities and adequate user support; and (iv) a collection centre of printed material. Such libraries can only take on an appropriate shape and will only survive if the institutions that librarians serve in meet the four criteria outlined above. We look at the demands that will be made on professional library knowledge and skills and the new job responsibilities and job attitudes required.  相似文献   

Guidelines for writers in electronic publishing and the multimedia. Edited by Jane Dorner The Authors’ Licensing and Collecting Society, 1996 Available from ALCS,Isis House, 74 New Oxford Street,London WC1A 1EF     

Alex Williamson 《Learned Publishing》1996,9(3):196-197

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Interdisciplinary scholarly collaboration in data-intensive,public-funded,international digital humanities project work     

Alex H. Poole  Deborah A. Garwood 《Library & information science research》2018,40(3-4):184-193

The information practices of collaborative interdisciplinary researchers, especially in distributed environments, remain understudied. Embracing the naturalistic paradigm, this qualitative case study relies upon semi-structured interviews, snowball sampling, and grounded analysis. Based on interviews with 53 participants from 11 Digging Into Data 3 (DID3, 2014-2016) projects, this study examines the working practices of scholars (library and information science professionals, humanists, and computer scientists) engaging in collaborative, international, data-intensive, publicly-funded interdisciplinary research. Benefits of such work include avoiding redundancy, exploding disciplinary silos, and more ambitious, larger-scale outputs. Challenges and lessons learned center on innovation, flexibility, and failure, translation, intermediaries, divisions of labor and delegation of responsibilities and tasks, conflict resolution, technology, outputs and publication, and timeframe, sustainability, and infrastructure.  相似文献   

Reciprocal Versus Nonreciprocal Assessment of Knee Flexors and Extensors in Concentric Actions Using the CON-TREX Multijoint Isokinetic Dynamometer: A Reliability Study     

Alex Bliss  Jeanne Dekerle 《Measurement in physical education and exercise science》2019,23(2):118-123

Knee flexor and extensor muscular assessment via isokinetic dynamometry is common practice and established in the research literature. However, reporting assessment methodology regarding reciprocal and nonreciprocal movements is often vague or absent. Such methodological issues are crucial for accurate assessments. Therefore, knee extensor and flexor peak moment using either reciprocal movement or nonreciprocal modalities was assessed. Fifteen participants performed three blocks of five concentric muscle actions at three angular velocities [1: nonreciprocal (maximal active flexion followed by passive extension); B2: reciprocal (maximal active extension followed by maximal active flexion); B3 nonreciprocal (maximal active extension followed by passive flexion)]. ANOVA revealed statistically significant within-subject modality effects for peak knee extensor moment and flexor velocity and modality differences (p < .05). Reciprocal and nonreciprocal assessments give significantly different results, with nonreciprocal giving higher peak moments. Reporting which modality is used is crucial to allow for greater clarity for the reader and practitioner.  相似文献   

In Memory of Michael Rosenak: Scholarly,Personal, Exceptional     

Alex Pomson 《Journal of Jewish Education》2014,80(4):343-345

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Resting Bradycardia,Enhanced Postexercise Heart Rate Recovery and Cardiorespiratory Fitness in Recreational Ballroom Dancers     

Carlos Janssen Gomes da Cruz  Guilherme Eckhardt Molina  Luiz Guilherme Grossi Porto  Luiz Fernando Junqueira Jr 《Research quarterly for exercise and sport》2017,88(3):371-376

Purpose: In a cross-sectional study design, we evaluated the resting heart rate (HR_baseline) and exercise and postexercise stress test-related chronotropic responses in male practitioners of recreational ballroom dancing (BD; n = 25, M_age = 26.6 ± 6.1 years) compared to a control group of insufficiently active nondancers (CG; n = 25, M_age = 25.9 ± 4.5 years). Method: All participants underwent a submaximal exercise test. At 85% of the maximal predicted HR, the recovery protocol was started, and heart rate recovery (HRR) was recorded during 1-min intervals for 5 min. Results: Compared with CG, BD showed lower HR_baseline (70 beats per minute [bpm] vs. 62 bpm, respectively, U = 143, p < .05, ES = .46), lower preexercise HR (94 bpm vs. 86 bpm, U = 157, p < .05, ES = .42), longer exercise test duration (346 s vs. 420 s, U = 95.5, p < .05, ES = .59), and higher HRR for 5 min postexercise (U = 1.29–1.89, p < .05, ES = .33–.50) as follows: 1st min (32 bpm vs. 40 bpm), 2nd min (45 bpm vs. 53 bpm), 3rd min (51 bpm vs. 58 bpm), 4th min (55 bpm vs. 59 bpm), and 5th min (59 bpm vs. 63 bpm). The coefficient of HRR from the 1st min to the 5th min postexercise was similar in both groups (U = 229–311, p > .05, ES = < .10–.22). Conclusion: Heightened cardiovascular functional status characterized by favorable enhanced chronotropic dynamics appears to occur in practitioners of recreational ballroom dancing, which suggests that this modality of exercise may result in health benefits.  相似文献   

A Comparative Analysis of Graduate Employment Prospects in European Labour Markets: A Study of Graduate Recruitment in Four Countries          下载免费PDF全文

Mohamed Branine  Alex Avramenko 《Higher Education Quarterly》2015,69(4):342-365

The aim of this paper is to provide a comparative analysis of higher education and the graduate labour markets in selected European countries (France, Germany, Spain and United Kingdom) in the context of the expectations of graduates and prospective employers, and respective recruitment and selection practices. Expectations of graduating students from a number of European collaborating universities are sought and analysed in order to find out about a match between the knowledge and skills of graduates and the needs of European employers. The study examines the process of graduate recruitment, employee and employer expectations, and the role of higher education institutions in meeting such expectations. Primary data was gathered from 252 employers and 485 final year (graduating) students through the use of questionnaires. The analysis of the data collected has revealed different approaches to but similar methods of graduate recruitment between the four countries. Despite the current differences in higher education systems and labour market trends, the expectations of employers and graduating students are more similar than different. It is concluded that EU graduates will have good employment prospects in an integrated labour market.  相似文献   

Paving the Olympic Dream: The Politics of the 2007 Pan-American Games in Rio de Janeiro     

Guilherme Nothen 《国际体育史杂志》2016,33(1-2):203-216

Abstract

The making of the 2007 Pan-American Games, held in the city of Rio de Janeiro, marked the beginning of the long transformation that this city would undergo in connection to sports mega-events. This paper revisits how the 2007 Pan-American Games were largely produced under the promise that its legacies, particularly the infrastructural ones, could be effectively mobilized in order to strengthen the chances of bringing the Olympics to Brazil for the first time. Whereas this rhetoric has proven somewhat successful in helping the city to secure the right to host the 2016 Olympics, the alleged connection between both events has shown to be much more limited than its proponents had initially advertized. In reality, most of the venues constructed for the Pan-American Games had to be thoroughly renovated for the Olympics, while some of them presented structural problems and/or failed to meet the standards imposed by international sports federations.  相似文献