Carnosine in health and disease     

Guilherme Giannini Artioli  Craig Sale  Rebecca Louise Jones 《European Journal of Sport Science》2019,19(1):30-39

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.  相似文献   

Children Talking to Learn     

Christine Craig 《Literacy》1994,28(2):2-5

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Untainted by money     

Loehle C 《New scientist (1971)》1997,155(2095):44

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Setting the Students’ Bearings and Balance in Appraisal     

Barbara L. Craig 《Archival Science》2005,5(2-4):391-402

The author, a professor at the University of Toronto, touches briefly on the extensive and rich archival literature that supports the teaching of macroappraisal, but notes that this is not the only educational material she offers her students when teaching appraisal theory. She discusses the usefulness to archivists of literature from the fields of ethnography, organizational knowing, records in history, personal documentary behaviour, memory, and communications, noting that the use of texts from these fields can encourage students to reflect on their own presumptions and to develop a taste for the wide reading and research that must support appraisal.  相似文献   

Strength in Numbers: Encouraging Every Staff Member to Work to Capacity     

Cathy Oxley 《International Information and Library Review》2018,50(1):69-75

Libraries play a critical role in enhancing the learning landscape of the schools they support. In order for any library to become a powerhouse and a community meeting place, all library team members need to align with the library's vision, own it and begin to add their own strengths and talents purposefully. This article explores practical strategies for developing a visionary team, including supportive leadership, daily stand-up meetings, weekly staff meetings, special-focus teams, rostering and the “five conversations” approach. These effective strategies can be implemented across a broad range of library workforce contexts in order to ensure the most effective workforce teams are built.  相似文献   

Using word embeddings in Twitter election classification     

Xiao Yang  Craig Macdonald  Iadh Ounis 《Information Retrieval》2018,21(2-3):183-207

Word embeddings and convolutional neural networks (CNN) have attracted extensive attention in various classification tasks for Twitter, e.g. sentiment classification. However, the effect of the configuration used to generate the word embeddings on the classification performance has not been studied in the existing literature. In this paper, using a Twitter election classification task that aims to detect election-related tweets, we investigate the impact of the background dataset used to train the embedding models, as well as the parameters of the word embedding training process, namely the context window size, the dimensionality and the number of negative samples, on the attained classification performance. By comparing the classification results of word embedding models that have been trained using different background corpora (e.g. Wikipedia articles and Twitter microposts), we show that the background data should align with the Twitter classification dataset both in data type and time period to achieve significantly better performance compared to baselines such as SVM with TF-IDF. Moreover, by evaluating the results of word embedding models trained using various context window sizes and dimensionalities, we find that large context window and dimension sizes are preferable to improve the performance. However, the number of negative samples parameter does not significantly affect the performance of the CNN classifiers. Our experimental results also show that choosing the correct word embedding model for use with CNN leads to statistically significant improvements over various baselines such as random, SVM with TF-IDF and SVM with word embeddings. Finally, for out-of-vocabulary (OOV) words that are not available in the learned word embedding models, we show that a simple OOV strategy to randomly initialise the OOV words without any prior knowledge is sufficient to attain a good classification performance among the current OOV strategies (e.g. a random initialisation using statistics of the pre-trained word embedding models).  相似文献   

Modern dietary guidelines for healthy pregnancy; maximising maternal and foetal outcomes and limiting excessive gestational weight gain     

Kirsty Jayne Elliott-Sale  Ashley Graham  Stephanie Jane Hanley  Sherry Blumenthal  Craig Sale 《European Journal of Sport Science》2019,19(1):62-70

Abstract

Maternal dietary habits influence maternal and foetal health, representing a pathway for intervention to maximise pregnancy outcomes. Advice on energy intake is provided on a trimester basis, with no additional calories required in the first trimester and an additional 340?kcal?d^?1 and 452?kcal?d^?1 needed for the second and third trimesters. Energy intake depends on pre-gravid body mass index (BMI); underweight women are recommended an increase of 150, 200 and 300?kcal?d^?1 during the first, second and third trimester, normal weight women an increase of 0, 350 and 500?kcal?d^?1 and obese women an increase of 0, 450 and 350?kcal?day^?1. The recommendations for carbohydrate and protein intake are 175?g?d^?1 and 0.88–1.1?g?kgBM?d^?1, with no change to fat intake. The number of pre-gravid obese women is rising; therefore, we need to regulate weight in women of childbearing age and limit gestational weight gain to within the recommended ranges [overweight women 6.8–11.3?kg and obese women 5.0–9.1?kg]. This can be achieved using nutritional interventions, as dietary changes have been shown to help with gestational weight management. As pregnancy has been identified as a risk factor for the development of obesity, normal weight women should gain 11.5–16.0?kg during pregnancy. While some research has shown that dietary interventions help to regulate gestational weight gain and promote postpartum weight loss to some extent, future research is needed to provide safe and effective guidelines to maximise these effects, while benefitting maternal and foetal health.  相似文献   

Destined to Design? How and Why Australian Women Choose to Study Industrial Design     

Cathy Lockhart  Evonne Miller 《The International Journal of Art & Design Education》2016,35(2):213-228

Despite over three decades of legislation and initiatives designed to tackle the traditional gender divide in the science, technology and design fields, only a quarter of the registered architects in Australia are women. There are no statistics available for other design disciplines, with little known about why women choose design as a career path and who or what influences this decision. This qualitative research addresses this knowledge gap, through semi‐structured in‐depth interviews conducted with 19 Australian women who completed an industrial (product) design degree. Thematic analysis revealed three key themes: childhood aptitude and exposure; significant experiences and people; and design as a serendipitous choice. The findings emphasise the importance of early exposure to design as a potential career choice, highlighting the critical role played by parents, teachers, professionals and social networks.  相似文献   

The effects of physical contact type on the internal and external demands during a rugby league match simulation protocol     

Jonathan P. Norris  Jamie Highton  Stephen F. Hughes  Craig Twist 《Journal of sports sciences》2016,34(19):1859-1866

The aim of this study was to investigate how the type of contact influences physiological, perceptual and locomotive load during a simulated rugby league match. Eleven male university rugby league players performed two trials of the rugby league movement simulation protocol for interchange forwards with a traditional soft tackle bag and a weighted tackle sled to replicate contact demands. The interchange forward-specific simulation was chosen given the contact frequency is higher for this group of players compared to whole match players. Locomotive rate, sprint speed, tackle intensity, heart rate (HR) and rating of perceived exertion were analysed during the first and second bouts that replicated two ~23 min on-field passages. Countermovement jump (CMJ) was measured before and immediately after each trial. More time was spent in heart rate zone between 91 and 100% HR_peak during the first (effect size ± 90% confidence interval: 0.44 ± 0.49) and second bouts (0.44 ± 0.43), and larger (0.6 ± 0.69) decrements in CMJ performance were observed during the sled trial (5.9, s = 4.9%) compared to the bag trial (2.6, s = 5.4%). Changing the type of contact during the match simulation subtly altered both the internal and external loads on participants. Using a standard tackle bag results in faster sprint speed to contact, but lower overall high-intensity running. Conversely, a heavier tackle object increases the internal load and results in greater lower limb neuromuscular fatigue as reflected by the decrease in CMJ performance.  相似文献   

Sex,sport and justice: reframing the ‘who’ of citizenship and the ‘what’ of justice in European and UK sport policy     

Cathy Devine 《Sport, Education and Society》2016,21(8):1193-1212

Universalist claims are often made about sport which is, as a consequence, increasingly written into national and international policy as an entitlement of citizenship or even human right. Further, in most countries physical education (PE) is a compulsory component of children's education, and sport is seen as central to this. Consequently, in the interests of justice sport must aspire to be egalitarian, that is, relevant to and meaningful for boys and men, and girls and women. In this context three fundamental questions are asked in relation to sport: (1) Do all citizens want to participate? (2) Who counts as a citizen? and (3) What are justice and equality? Feminist political and citizenship theory particularly the work of Pateman, Lister and Fraser is used to explore these questions and interrogate the ‘who’ of citizenship and the ‘what’ of justice in relation to framing sport policy in Europe and the UK. It is argued that notwithstanding the extensive use of the Council of Europe definition of sport,¹1. ‘“Sport” means all forms of physical activity which, through casual or organised participation, aim at expressing or improving physical fitness and mental well-being, forming social relationships or obtaining results in competition at all levels' (CE, 1992 CE. (1992/2001). European sports charter. Retrieved from https://wcd.coe.int/ViewDoc.jsp?Ref=Rec(92)13&;Sector=secCM&;Language=lanEnglish&;Ver=rev&;BackColorInternet=9999CC&;BackColorIntranet=FFBB55&;BackColorLogged=FFAC75 [Google Scholar]–2001 CE. (1992/2001). European sports charter. Retrieved from https://wcd.coe.int/ViewDoc.jsp?Ref=Rec(92)13&;Sector=secCM&;Language=lanEnglish&;Ver=rev&;BackColorInternet=9999CC&;BackColorIntranet=FFBB55&;BackColorLogged=FFAC75 [Google Scholar]). and despite or even because of the widespread adoption of the language of gender equality and gender mainstreaming, although formal sport citizenship rights might be accorded to all individuals and regarded as gender neutral, this masks a discourse of androcentric sport citizenship. This has captured European and UK sport policy and provision and is hindering further progress towards gender justice in sport and therefore PE. Given the universal and compulsory aspirations of sport particularly within PE, gender justice should be conceptualised not only as cultural recognition, political representation and economic redistribution within the normalised frame of competitive performance sport or ‘sport for sports sake’; but also as a critical meta-political remapping and reframing of sport as sport and physical recreation or ‘sport for all’.  相似文献