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1.
Rukmini M. S. Benedicta D'Souza Vivian D'Souza 《Indian journal of clinical biochemistry : IJCB》2004,19(2):114-118
Free radical mediated pathological processes may have a role in schizophrenia. Free radicals (oxy radicals, such as superoxide,
hydroxyl ions and nitric oxide) cause cell injury, when they are generated in excess or when the antioxidant defense is impaired.
Both these processes seem to be affected in schizophrenia. In this study we investigated erythrocyte superoxide dismutase
(SOD) and catalase (CAT) activities as antioxidant enzymes, malondialdehyde (MDA) as a sign of lipid peroxidation in schizophrenic
patients. Activities of superoxide dismutase, catalase and malondialdehyde were greater in patients compared with the control
group which may reflect increased oxidative stress in the brain tissue of schizophrenics. In the patient group erythrocyte
SOD and CAT activities were weakly negative correlated with MDA concentration. These data reveal that antioxidant defense
mechanisms might be impaired in schizophrenic patients. These findings also provide a theoretical basis for the development
of novel therapeutic strategies, such as antioxidant supplementation. 相似文献
2.
Herman S D'Souza Geraldine Menezes T Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):1-4
Our study aimed at comparing lead and zinc protoporphyrin (ZPP) levels in capillary and venous blood samples in a small population
and to employ an easier method of sample collection for a major screening program in school children in major Indian cities.
An awareness program on lead and its effects was conducted in two different schools. A total of thirty urban school children
from South India, with an age group between 4–12 years consented for dual blood sampling and reported for the study. Venous
and capillary blood samples were obtained simultaneously. Blood lead and zinc protoporphyrin (ZPP) levels were estimated using
ESA Lead Analyzer and Haematofluorometer respectively. A significant correlation between capillary and venous ZPP (r=0.98)
and lead (r=0.99) was observed. Rank sum test showed that there is no statistically significant difference between capillary
and venous ZPP (P=0.891) and lead (P=0.672) values. This pilot study recommends that screening for lead may be done using
capillary blood samples since significant correlation is observed between capillary and venous blood measurements. Obtaining
samples using this mode is a non-invasive, less expensive, quick and easy method in children. Appropriately performed capillary
sampling may be considered as an acceptable alternative to venipuncture for screening of blood for lead poisoning both in
children and adults. 相似文献
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4.
Karen M. D'Souza Tester F. Ashavaid 《Indian journal of clinical biochemistry : IJCB》2007,22(1):37-44
This study was aimed at isolating, in its pure form, and characterizing the sarcoplasmic reticulum from caprine (Capra hircus) heart. The sarcoplasmic reticulum from thirty caprine heart ventricular homogenates was isolated and purified. It was characterized
on the basis of both, its protein and lipid composition. The protein content was 142±10 mg/g of tissue. Ca2+-ATPase activity equaled 3.75±1.06mmol Pi/mg protein/min while the uptake rate was 24±1.14 nmol/mg protein/min. 205kD, 110kD,
90kD, 84kD, 66kD, 55kD and 29kD molecular weight proteins were seen on an SDS polyacrylamide gel. Triglyceride, Cholesterol
and Phospholipids (phosphatidylethanolamine, phosphatidylinositol, phosphatidylcholine, sphingomyelin and phosphatidylserine)
were present in increasing order of their concentration. Long chain fatty acids predominated over the unsaturated ones. The
ryanodine receptor displayed two binding sites for ryanodine. Characterisation encompassing the above biochemical aspects
of normal caprine cardiac sarcoplasmic reticulum was thus achieved after isolating it in the pure form. 相似文献
5.
Susceptibility of Schizophrenic patients to lipid peroxidation relative to healthy control subjects was investigated by measuring
the malondialdehyde (MDA) levels in plasma. The main finding was that Schizophrenic patients were more susceptible than control
subjects to oxidative damage as evident from increased MDA levels in plasma. Antioxidant levels are also depleted in Schizophrenic
patients when compared to normal subjects as evident from decreased levels of vitamins E and C in the plasma. Impaired antioxidant
defense and increased lipid peroxidation suggests that treatment with antioxidants (Vitamin E, Vitamin C, beta carotene) at
the initial stages of illness may prevent further oxidative injury and deterioration of associated neurological deficits in
Schizophrenia. 相似文献
6.
Mario O. D'Souza 《Religious education (Chicago, Ill.)》2013,108(3):233-249
Abstract Multiculturalism is official Canadian policy. In the context of postmodernism, pluralism has taken on a sharper meaning, particularly with regard to identity. What can possibly unify a diverse nation like Canada? Does the separation of religion from public life make sense when cultural identity includes religious expression? Political unity, religious diversity, and the common search for and establishment of justice could become the essential building blocks toward an integral political unity. In particular, the celebration of religious diversity in Canada's schools could become a primary means of political unity as well as an essential means of unifying society. Five convictions are developed which help secure a new relationship among religious education, religious diversity, and political and societal unity. 相似文献
7.
ANALYSIS OF CONTENTS,CONTRIBUTORS, AND RESEARCH DIRECTIONS: MAPPING PUBLICATION ROUTES IN THE JOURNAL 总被引：1，自引：1，他引：0
Leona M. English Mario O. D'Souza Leon Chartrand 《Religious education (Chicago, Ill.)》2013,108(1):6-19
A content analysis of the journal Religious Education: An Interfaith Journal of Spirituality, Growth and Transformation was conducted for a 10-year period between 1993–2002 (Volume 88, 1–Volume 97, 4). A total of 325 articles (277 authors) were analyzed into 3 primary research directions (theoretical, qualitative, and quantitative). Author institutional affiliation, religious identity, position, geographic location, and number of contributions were also computed. Implications for the Journal and the field of religious education are discussed. 相似文献
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Herman Sunil D'Souza Geraldine Menezes T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2003,18(2):154-160
Heavy metals are important toxicants known to exert adverse effects in humans and animals, given sufficient exposure and accumulation
in the body. This has a great concern both at personal and public health risk. Heavy metals are also known to interact with
the essential trace minerals at the level of absorption and also during the metabolism. The adverse effects of the absorbed
and accumulated heavy metals include neurological, reproductive, renal and hematological systems. Children are more sensitive
than adults to the effects of lead. Efforts are made to understand the mechanism of the interactions of heavy metals with
essential trace minerals at the level of absorption. With available sensitive and specific methodologies like Anodic Stripping
Voltammetry for the evaluation of the levels of toxic heavy metals such as lead, cadmium, mercury etc., better understanding
of heavy metal absorption is made possible.
Due to the poor nutritional standards, risk of heavy metal exposure is still a major concern in developing countries. Studies
carried out by the author have provided evidence towards the understanding of the prevailing mechanisms of metal-metal interaction
at the intestinal level. During growth and development the demand for the essential minerals being at higher level, differentiation
of various essential metals and heavy metals pose an inherent problem due to certain common properties shared by them. With
this approach to the problem of heavy metal toxicity, it is preventable not only with environmental intervention but also
by the nutritional management. 相似文献
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