Carnosine in health and disease     

Guilherme Giannini Artioli  Craig Sale  Rebecca Louise Jones 《European Journal of Sport Science》2019,19(1):30-39

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.  相似文献   

A Tribute to Steve Balch     

Peter Wood 《Academic Questions》2009,22(2):226-233

  相似文献   

Can constrained relevance feedback and display strategies help users retrieve items on mobile devices?     

Vishwa Vinay  Ingemar J. Cox  Natasa Milic-Frayling  Ken Wood 《Information Retrieval》2006,9(4):435-453

Searching online information resources using mobile devices is affected by small screens which can display only a fraction of ranked search results. In this paper we investigate whether the search effort can be reduced by means of a simple user feedback: for a screenful of search results the user is encouraged to indicate a single most relevant document. In our approach we exploit the fact that, for small display sizes and limited user actions, we can construct a user decision tree representing all possible outcomes of the user interaction with the system. Examining the trees we can compute an upper limit on relevance feedback performance. In this study we consider three standard feedback algorithms: Rocchio, Robertson/Sparck-Jones (RSJ) and a Bayesian algorithm. We evaluate them in conjunction with two strategies for presenting search results: a document ranking that attempts to maximize information gain from the user’s choices and the top-D ranked documents. Experimental results indicate that for RSJ feedback which involves an explicit feature selection policy, the greedy top-D display is more appropriate. For the other two algorithms, the exploratory display that maximizes information gain produces better results. We conducted a user study to compare the performance of the relevance feedback methods with real users and compare the results with the findings from the tree analysis. This comparison between the simulations and real user behaviour indicates that the Bayesian algorithm, coupled with the sampled display, is the most effective. Extended version of “Evaluating Relevance Feedback Algorithms for Searching on Small Displays, ” Vishwa Vinay, Ingemar J. Cox, Natasa Milic-Frayling, Ken Wood published in the proceedings of ECIR 2005, David E. Losada, Juan M. Fernández-Luna (Eds.), Springer 2005, ISBN 3-540-25295-9  相似文献   

Along the Write Lines: a case study exploring activities to enable creative writing in a secondary English classroom.     

Audrey B. Wood 《English in Education》2016,50(2):130-147

This article arises from a four week study of a class of 14‐15 year old students. The study explored students’ perception of themselves as writers and the effects of a variety of teaching and learning strategies on their creative writing responses. The aim of the project was to enhance the students’ creative writing, whilst ascertaining whether there were particular activities or types of writing that would lead to students perceiving more satisfactory outcomes in their writing. It answers the research question: What do I observe, and what do my students say, about the experience of different classroom based creative writing tasks?  相似文献   

A collaboratively constructed action leadership framework for sustainable learner support in contexts of adversity     

Rubina Setlhare  Lesley Wood 《Educational Action Research》2020,28(2):227-241

  相似文献   

Resting Bradycardia,Enhanced Postexercise Heart Rate Recovery and Cardiorespiratory Fitness in Recreational Ballroom Dancers     

Carlos Janssen Gomes da Cruz  Guilherme Eckhardt Molina  Luiz Guilherme Grossi Porto  Luiz Fernando Junqueira Jr 《Research quarterly for exercise and sport》2017,88(3):371-376

Purpose: In a cross-sectional study design, we evaluated the resting heart rate (HR_baseline) and exercise and postexercise stress test-related chronotropic responses in male practitioners of recreational ballroom dancing (BD; n = 25, M_age = 26.6 ± 6.1 years) compared to a control group of insufficiently active nondancers (CG; n = 25, M_age = 25.9 ± 4.5 years). Method: All participants underwent a submaximal exercise test. At 85% of the maximal predicted HR, the recovery protocol was started, and heart rate recovery (HRR) was recorded during 1-min intervals for 5 min. Results: Compared with CG, BD showed lower HR_baseline (70 beats per minute [bpm] vs. 62 bpm, respectively, U = 143, p < .05, ES = .46), lower preexercise HR (94 bpm vs. 86 bpm, U = 157, p < .05, ES = .42), longer exercise test duration (346 s vs. 420 s, U = 95.5, p < .05, ES = .59), and higher HRR for 5 min postexercise (U = 1.29–1.89, p < .05, ES = .33–.50) as follows: 1st min (32 bpm vs. 40 bpm), 2nd min (45 bpm vs. 53 bpm), 3rd min (51 bpm vs. 58 bpm), 4th min (55 bpm vs. 59 bpm), and 5th min (59 bpm vs. 63 bpm). The coefficient of HRR from the 1st min to the 5th min postexercise was similar in both groups (U = 229–311, p > .05, ES = < .10–.22). Conclusion: Heightened cardiovascular functional status characterized by favorable enhanced chronotropic dynamics appears to occur in practitioners of recreational ballroom dancing, which suggests that this modality of exercise may result in health benefits.  相似文献   

Vikings in the South: Voyages to Iberia and the Mediterranean     

Jamie Wood 《Al-Masaq: Islam & the Medieval Mediterranean》2016,28(1):110-111

  相似文献   

Books,Articles, and Items of Academic Interest     

Peter Wood 《Academic Questions》2017,30(2):245-252

  相似文献   

The wellbeing toolkit for professionals working with children and young people     

Chris Wood 《Educational Psychology in Practice》2017,33(2):228-229

  相似文献   

Books Articles,and Items of Academic Interest     

Peter Wood 《Academic Questions》2014,27(2):244-251

  相似文献