Prostate specific antigen in patients of benign prostate hypertrophy and carcinoma prostate     

T. Malati  G. Rajani Kumari  P. V. L. N. Murthy  Ch. Ram Reddy  B. Surya Prakash 《Indian journal of clinical biochemistry : IJCB》2006,21(1):34-40

Prostate Specific Antigen (PSA) has emerged as the most applicable and important tumor marker for carcinoma prostate. In the present study PSA was determined in serum of healthy subjects, patients of benign prostate hypertrophy (BPH) and Carcinoma Prostate (Ca−P) to evaluate its diagnostic efficiency in day to day management of prostate cancer patients and in differentiating patients of early prostate cancer from those with BPH. Receiver operating characteristic curve (ROC) revealed 2 ng/ml and 10 ng/ml cut off serum PSA level for BPH and untreated carcinoma prostate patients (Ca−P). An extremely significant increase (P<0.0001) was observed in mean PSA concentration in BPH patients and adenocarcinoma prostate patients when compared to healthy males. Clinical relevance of PSA was highlighted by a case study of cancer patient prior to any therapy till death.  相似文献   

A preliminary report on the role of yoga asanas on oxidative stress in non-insulin dependent diabetes mellitus     

Savita Singh  Varun Malhotra  K. P. Singh  S. B. Sharma  S. V. Madhu  O. P. Tandon 《Indian journal of clinical biochemistry : IJCB》2001,16(2):216-220

Nineteen subjects of non-insulin dependent diabetes mellitus (NIDDM) between the age group of 30–60 yrs were studied to see the effect of specific yoga asanas on fasting and postprandial blood glucose (FBG, PPG), serum malondialdehyde (MDA) and glycosylated hemoglobin (HbA₁) in addition to drug treatment and diet control. The duration of diabetes ranged from 1–10 years. Patients with renal, cardiac and proliferative retinal diseases were excluded from the study. The same patients served as their own control. Subjects were called in the morning to the cardio-respiratory laboratory and were given training by a yoga expert. Yoga asanas included Suryanamskar, Tadasan, TriKonasan, Padmasan, Pranayam, Paschimottanasan, Ardhmatsyendrasan, Pavanmukthasan, Sarpasan and Shavasan. The asanas were done every day for 40 days for 30–40 min. FBG, PPG, serum MDA and HbA₁ were estimated before and after 40 days of yoga asanas regimen. Significant reduction was seen in FBG from 220 mg/dl to 162 mg/dl, PPG from 311 mg/dl to 255 mg/dl, MDA from 6 nmol/l to 3 nmol/l and HbA₁, from 8.8% to 6.4%. Subjects felt better and were relieved of their stresses and had an improvement in their day to day performance. The decrease was statistically significant (p<0.0001 for FBG and PPG, p<0.001 for MDA and for HbA₁).  相似文献   

Cortical network for reading linear words in an alphasyllabary     

Tanusree Das  Raju S. Bapi  Prakash Padakannaya  Nandini C. Singh 《Reading and writing》2011,24(6):697-707

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Effect of Vitamin E on sP-Selectin Levels in Pre-Eclampsia     

Wangkheimayum S  Kumar S  Suri V 《Indian journal of clinical biochemistry : IJCB》2011,26(2):169-171

P-selectin, a cell adhesion molecule is elevated in many inflammatory conditions including preeclampsia which is characterized by generalized endothelial dysfunction and vasoconstriction presumably due to free radicals or mediators released by defective placentation. Vitamin E has been documented to protect cell membranes from oxidative damage and also decrease platelet aggregation. The role of vitamin E in pre-eclampsia is contradictory and hence the study was undertaken. Soluble P-selectin was measured by ELISA and Vitamin-E levels in plasma was estimated spectrofluorometrically. In our study the effect of supplementation of 400 IU/day of Vitamin E (a-tocopheryl acetate) to patients of pre-eclampsia showed significant decreased levels of soluble P-selectin by 2nd week as compared to patients given placebo (P = 0.005). In this short period of study no direct correlations were observed between Vitamin E or P-selectin levels with blood pressure as well as with proteinuria. Future studies may focus on the effect of a-tocopheryl acetate or the phosphate form of Vitamin-E, recently proposed to be the more active form on other inflammatory markers like IL-6, an important stimuli of P-selectin release in pre-eclampsia.  相似文献   

Serum total PSA and free PSA in breast tumors     

Dash P  Pati S  Mangaraj M  Sahu PK  Mohapatra PC 《Indian journal of clinical biochemistry : IJCB》2011,26(2):182-186

Now a days measurement of molecular forms of PSA has gained importance in clinical practice. Several studies have demonstrated the production of PSA in female tissues, such as breast. The present piece of work has been undertaken with an objective to estimate the relative proportion of the molecular forms of PSA in serum along with serum testosterone in benign and malignant breast tumor cases and to analyze their association with the severity of the disease process 34 malignant and 26 benign breast disease cases along with 33 healthy controls of same age group were enrolled in this study for evaluation. Serum testosterone was measured by ELISA, whereas serum total PSA (TPSA) and free PSA (FPSA) were estimated by electrochemiluminescence immunoassay. A significant rise of fasting plasma glucose along with prominent dyslipidemia was observed in breast tumor cases. Marked rise in serum testosterone as well as TPSA and FPSA was documented in both benign and malignant breast tumor cases. Serum testosterone revealed a significant positive association with both TPSA and FPSA pointing towards an etiological association between them. However, surgical removal of tumor mass resulted in a marked decline of presurgical value of both TPSA and FPSA with a non-significant fall in serum testosterone revealing tumor tissue as the source of FPSA and TPSA. Thus, estimation of PSA provides prognostic information that may assist in future treatment.  相似文献   

Effects of roller burnishing process parameters on surface roughness of A356/5%SIC composite using response surface methodology     

Shashi Prakash Dwivedi Satpal Sharma Raghvendra Kumar Mishra 《上海大学学报(英文版)》2014,(4):303-317

In this study, a simple roller burnishing tool was made to operate burnishing processes on A356/5%SIC metal matrix composite fabricated by electromagnetic stir casting under different parameters. The effects of burnishing speed, burnishing force and number of burnishing passes on the surface roughness and tribological properties were measured. Scanning electron microscopy （SEM） graphs of the machined surface with PCD （insert-10） tool and roller burnished surface with tungsten carbide （WC） roller were taken into consider- ation to observe the surface finish of metal matrix composites. The mechanical properties （tensile strength, hardness, duc- tility） of A356/5%SIC metal matrix composites were studied for both unburnished samples and burnished samples. The results revealed that the roller burnished samples of A356/ 5%SIC led to the improvement in tensile strength, hardness and ductility. In order to find out the effects of roller bur- nishing process parameters on the surface roughness of A356/ 5%SIC metal matrix composite, response surface methodol- ogy （RSM） （Box-Behnken design） was used and a prediction model was developed relevant to average surface roughness using experimental data. In the range of process parameters, the result shows that roller burnishing speed increases, and surface roughness decreases, but on the other hand roller burnishing force and number of passes increase, and surface roughness increases. Optimum values of burnishing speed （1.5 m/s）, burnishing force （50 N） and number of passes （2） during roller burnishing of A356/5%SIC metal matrix com- posite to minimize the surface roughness （predicted 1.232 μm） have been found out. There was only 5.03% error in the experimental and modeled results of surface roughness.  相似文献   

End-user satisfaction of technology-enabled assessment in higher education: A coping theory perspective     

Pillai  K. R.  Upadhyaya  Pallavi  Prakash  Ashish Viswanath  Ramaprasad  Badrinarayan Srirangam  Mukesh  H. V.  Pai  Yogesh 《Education and Information Technologies》2021,26(4):3677-3698

Education and Information Technologies - The current study examines students’ coping process of a forced technological intervention in academic outcome assessment in a higher education...  相似文献   

Nature watch     

Ishwar Prakash 《Resonance》1997,2(10):54-61

Gerbils are rodents with a long hairy tail terminating in a tassel of hair.Gerbillus, Tatera andMeriones are the genera found in India. These rodent genera of Sahara-Tharian region differ from each other in their origin and dispersal. Since a large number of species of the genusGerbillus are found in the African continent, it is conjectured that Africa was the centre of their differentiation. However,Tatera is found only south of Sahara.Meriones of Asiatic origin which crossed over to northern Africa across the Sinai desert is now found in Egypt, Libya, Algeria, Tunisia, Morocco and several parts of Asia.  相似文献   

Special relativity — An exoteric narrative     

S. R. Madhu Rao 《Resonance》1998,3(5):63-72

Some time earlier¹ we treated our readers to an exoteric narrative of special relativity’s kinematics in which we shunned the use of mathematical formulas. However, the simple and concise account presented then has left quite a few questions open, and we now present the promised sequel to supply the requisite answers.  相似文献   

Dietary Fats and Oxidative Stress: A Cross-Sectional Study Among Coronary Artery Disease Subjects Consuming Coconut Oil/Sunflower Oil     

Sabitha Palazhy  Prakash Kamath  D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2018,33(1):69-74

Coconut oil has been used by the people of Kerala as a cooking medium for several decades. Due to its alleged hypercholesterolemic activity, general population in recent times is shifting to cooking oils rich in polyunsaturated fats, the most popular being sunflower oil. The effect of long-term consumption of sunflower oil on oxidative stress in humans is not well investigated. We studied oxidative stress among coronary artery disease (CAD) patients who were consuming coconut oil or sunflower oil as a part of their routine diet. Men, aged 35–70 years, with established CAD, who presented to the hospital for routine cardiac evaluations, were enrolled in this observational study. Group 1 and 2 consisted of 73 and 80 subjects consuming coconut oil and sunflower oil respectively for over a period of 2 years. Lipid profile and parameters for oxidative stress were evaluated among them. Conventional lipid parameters did not differ significantly between the two groups. Mean vitamin C concentration was significantly reduced for subjects on sunflower oil compared to those consuming coconut oil (P = 0.044). Malondialdehyde was higher for sunflower oil consumers compared to coconut oil consumers (P < 0.0001). Other parameters such as oxidized LDL, GSH, GPx and SOD were not found to be significantly different between the two groups. The results of the present study show that coconut oil did not induce hypercholesterolemia compared to sunflower oil. On the other hand, sunflower oil group had elevated oxidative stress compared to coconut oil group.  相似文献