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In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. Wemay suggest strategies for dealingwith
them, or invite responses, or both. “Classroom” is equally a forum for raising broader issues and sharing personal experiences
and viewpoints on matters related to teaching and learning science. 相似文献
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Praveen Sharma P. K. Sharma D.Sc. J. Pramod L. K. Kothari Rashmi Ranka Sushma Sharma 《Indian journal of clinical biochemistry : IJCB》1989,4(1):62-64
Sixteen weeks of chronic vitamin C deficiency, induced in guinea pigs by restricted vitamin C intake, resulted in a marked
increase in the serum total LDL- and VLDL- cholesterol, triglycerides and total lipids. HDL-cholesterol decreased resulting
in a highly significant increase in LDL/HDL ratio. The results reconfirm that vitamin C deficiency causes changes in blood
lipid profile which could promote atherogenesis. 相似文献
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Khan S Bhargava A Pathak N Maudar KK Varshney S Mishra PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):161-168
The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered
a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients
was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and
circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its
kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections.
Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however,
role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk
individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our
study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma. 相似文献
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Gora Dadheech Praveen Sharma Shiv Gautam 《Indian journal of clinical biochemistry : IJCB》2012,27(3):278-283
Reactive oxygen species (ROS) formed in various metabolic reactions cause unlimited damage by attacking and oxidizing the macromolecules. An arsenal of antioxidant substances neutralizes these ROS at various sites of their metabolic cascade, and if disequilibrium exists between the pro and antioxidant system, oxidative stress persists. The present study was undertaken in schizophrenia, to highlight the response and role of some endogenous antioxidants viz. reduced glutathione (GSH), bilirubin, total proteins, albumin and uric acid in scavenging the ROS. The effect of severity of disease, age factor, and substance abuse was also studied. In all, 50 schizophrenics and 50 age and sex-matched controls were enrolled in the present study. Fasting blood samples were drawn for estimating malondialdehyde (MDA), GSH, bilirubin, total proteins, albumin and uric acid in both the groups. The results were statistically analyzed by Z-test and correlated using correlation coefficient (r). The study shows reduction in MDA levels and decline in the level of endogenous antioxidants, but within the normal range. Chronic schizophrenics were at a higher risk of oxidative stress and age and substance abuse seems to worsen the situation. 相似文献
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Matthew B. Rhudy Scott B. Dreisbach Matthew D. Moran Marissa J. Ruggiero Praveen Veerabhadrappa 《Journal of sports sciences》2020,38(5):503-510
ABSTRACTAccelerometer cut points are an important consideration for distinguishing the intensity of activity into categories such as moderate and vigorous. It is well-established in the literature that these cut points depend on a variety of factors, including age group, device, and wear location. The Actigraph GT9X is a newer model accelerometer that is used for physical activity research, but existing cut points for this device are limited since it is a newer device. Furthermore, there is not existing data on cut points for the GT9X at the ankle or foot locations, which offers some potential benefit for activities that do not involve arm and/or core motion. A total of N = 44 adults completed a four-stage treadmill protocol while wearing Actigraph GT9X sensors at four different locations: foot, ankle, wrist, and hip. Metabolic Equivalent of Task (MET) levels assessed by indirect calorimetry along with Receiver Operating Characteristic (ROC) curves were used to establish cut points for moderate and vigorous intensity for each wear location of the GT9X. Area under the ROC curves indicated high discrimination accuracy for each case. 相似文献
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Chitra Upadhyaya Sandhya Mishra P. P. Singh Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2005,20(1):30-34
Serum antioxidant status and peroxidative stress was estimated in 30 pregnant women, their newborn infants and 25 non-pregnant
women. Serum Ascorbic acid, α-tocopherol, retinol & β-carotene levels were found to be significantly reduced and peroxidative
stress was significantly higher in mothers as compared to matched non-pregnant women. Newborn had significantly higher levels
of ascorbic acid as compared to their mother but had significantly lower levels of lipid soluble vitamins. The peroxidative
stress in newborn was found to be significantly less as compared to their mothers. A positive correlation of ascorbic acid
and α-tocopherol levels between mother and newborn reflects that their status in mother does influence the newborn status. 相似文献
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Gora Dadheech Sandhya Mishra Shiv Gautam Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2006,21(2):34-38
A disturbance in the antioxidant defense system including α-tocopherol, ascorbic acid and reduced glutahtione metabolism due
to free radical induced oxidative injury has been implicated in various neuro-psychiatric disorders. The roles of these antioxidants,
changes in their blood levels and correlation with oxidative stress were studied in a common psychiatric illness Schizophrenia.
Fifty-eight subjects of either sex ranging in age from 18–60 years divided into two age groups (≤40 and >40 years) diagnosed
for schizophrenia, and forty age and sex-matched normal subjects as controls were included in the study. Blood samples were
analyzed for malondialdehyde (MDA), α-tocopherol, total ascorbic acid (TAA), dehydro ascorbic acid (DHAA), reduced ascorbic
acid (RAA), leucocyte ascorbic acid (LAA) and reduced glutathione (GSH). A decrease in the levels of α-tocopherol, total ascorbic
acid and reduced glutathione was found in schizophrenics compared to normal controls. Further a significant rise in oxidative
stress and decreased antioxidant status was observed in the chronic stage of schizophrenia as compared to those in acute condition.
A significant rise in dehydroascorbic acid with concomitant fall in reduced ascorbic acid suggests scavenging action of ascorbic
acid and its utilization with increased oxidative stress as indicated by high blood malondialdehyde levels. Leucocyte ascorbic
acid, a better index of ascorbic acid status was also found to be reduced in schizophrenics, suggesting depletion of body
stores of ascorbic acid and the condition worsened with advancing age. 相似文献