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1.
Mariangela Palladino 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(3)
Coronavirus disease 2019 (COVID-19) pandemic represents a scientific and social crisis. One of the main unmet needs for coronavirus disease 2019 is its unpredictable clinical course, which can rapidly change in an irreversible outcome. COVID-19 patients can be classified into mild, moderate, and severe. Several haematological parameters, such as platelets, white blood cell total count, lymphocytes, neutrophils, (together with neutrophil-lymphocyte and platelet-lymphocyte ratio), and haemoglobin were described to be associated with COVID-19 infection and severity. The purpose of these review is to describe the current state of the art about complete blood count alterations during COVID-19 infection, and to summarize the crucial role of some haematological parameters during the course of the disease. Decreased platelet, lymphocyte, haemoglobin, eosinophil, and basophil count, increased neutrophil count and neutrophil-lymphocyte and platelet-lymphocyte ratio have been associated with COVID-19 infection and a worse clinical outcome. Our study adds some novelty about the identification of effective biomarkers of progressive disease, and might be helpful for diagnosis, prevention of complications, and effective therapy. 相似文献
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Himani Rathi Vishakha Burman Sudip Kumar Datta Satya Vati Rana Anissa Atif Mirza Sarama Saha Raman Kumar Manisha Naithani 《Indian journal of clinical biochemistry : IJCB》2021,36(1):3
In December 2019, Wuhan city in the Hubei province of China reported for the first time a cluster of patients infected with a novel coronavirus, since then there has been an outburst of this disease across the globe affecting millions of human inhabitants. Severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2), is a member of beta coronavirus family which upon exposure caused a highly infectious disease called novel coronavirus disease-2019 (COVID-19). COVID-19, a probably bat originated disease was declared by World Health Organization (WHO) as a global pandemic in March 2020. Since then, despite rigorous global containment and quarantine efforts, the disease has affected nearly 56,261,952 laboratory confirmed human population and caused deaths of over 1,349,506 lives worldwide. Virus passes in majority through respiratory droplets and then enters lung epithelial cells by binding to angiotensin converting enzyme 2 (ACE2) receptor and there it undergoes replication and targeting host cells causing severe pathogenesis. Majority of human population exposed to SARS-CoV-2 having fully functional immune system undergo asymptomatic infection while 5–10% are symptomatic and only 1–2% are critically affected and requires ventilation support. Older people or people with co-morbidities are severely affected by COVID-19. These categories of patients also display cytokine storm due to dysfunctional immune response which brutally destroys the affected organs and may lead to death in some. Real time PCR is still considered as standard method of diagnosis along with other serology, radiological and biochemical investigations. Till date, no specific validated medication is available for the treatment of COVID-19 patients. Thus, this review provides detailed knowledge about the different landscapes of disease incidence, etiopathogenesis, involvement of various organs, diagnostic criteria’s and treatment guidelines followed for management of COVID-19 infection since its inception. In conclusion, extensive research to recognize novel pathways and their cross talk to combat this virus in precarious settings is our future positive hope. 相似文献
3.
Mohana Kumari Chidananda Deepy Zohmangaihi Sant Ram Shiv Lal Soni Vikas Suri Pankaj Malhotra Ravjit Singh Jassal Jyotdeep Kaur Indu Verma Sadhna Sharma 《Indian journal of clinical biochemistry : IJCB》2021,36(4):485
Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a global health problem, India being the second most affected country. The kinetics of antibody response to SARS-CoV-2 in Indian population is not studied yet. To understand serological response in relation to age, gender, time period and severity of disease, Roche Elecsys anti-SARS-CoV-2 test was used which analysed both IgM and IgG. One hundred and three COVID-19 patients were enrolled. Seropositivity was seen in 64% of patients, with 33% at ≤ 7 days, 62% between 8 and 15 days and 81% at ≥ 16 days from the time of admission. Men (65%) showed higher antibody response than women (59%), whereas no difference was observed in seropositivity with respect to age of the patients. Dynamics of antibody responses revealed individual variations. Patients in ICU had higher antibody reactivity with 67% positivity as compared to 60% positivity in non-ICU patients. Kinetics of antibody response during COVID-19 disease varied in relation to gender, age, time period and severity and these factors might play an important role in treatment and control of COVID-19. 相似文献
4.
强化战略科技力量是实现科技自立自强的关键。我国新冠病毒疫苗研发取得阶段性胜利与国家战略科技力量有着密不可分的关系。文章从国内外新冠病毒疫苗研发现状入手,通过分析我国新冠病毒疫苗研发科研攻关的成功经验,进一步深入思考和探索我国战略科技力量的使命定位、顶层设计、强化方式,并就进一步强化我国战略科技力量提出相应的政策建议。 相似文献
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Anna Mrzljak
eljka Jurekovi&#x; Jadranka Pavi
i&#x;-&#x;ari&#x; Vladimir Stevanovi&#x; Irena Tabain
eljka Hru&#x;kar Danko Mikuli&#x; Ljubo Barbi&#x; Tatjana Vilibi&#x;-avlek 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(3)
IntroductionThe data on the coronavirus disease (COVID-19) in solid-organ transplant recipients (SOTRs) in Croatia is unknown. The aim of this study was to analyze the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Croatian SOTRs.Materials and methodsFrom 7 September to 27 November 2020 (beginning of the second COVID-19 pandemic wave), a cross-sectional screening for COVID-19 was performed in the adult outpatient liver (LTRs; N = 280) and kidney transplant recipients (KTRs; N = 232). Serum samples were initially tested for SARS-CoV-2 IgG antibodies using a commercial enzyme-linked immunosorbent assay (ELISA; Vircell Microbiologists, Granada, Spain). All positive samples were confirmed using a virus neutralization test (VNT). Data on risk exposure and COVID-19 related symptoms were collected using a questionnaire.ResultsThe transplanted cohort’s seroprevalence detected by ELISA and VNT was 20.1% and 3.1%, respectively. Neutralizing (NT) antibodies developed in 15.6% of anti-SARS-CoV-2 ELISA IgG positive SOTRs. The difference in seropositivity rates between LTRs and KTRs was not statistically significant (ELISA 21.1% vs. 19.0%, P = 0.554; VNT 3.6% vs. 2.6%, P = 0.082). Overall VNT positivity rates were higher in patients who reported participation in large community events (5.9% vs. 1.0%; P = 0.027) as well as in patients who reported COVID-19 related symptoms in the past six months. In addition, symptomatic VNT positive patients showed significantly higher (P = 0.031) NT antibody titers (median 128, interquartile range (IQR) = 32-128) compared to asymptomatic patients (median 16, IQR = 16-48).ConclusionsThis study showed that 15.6% of anti-SARS-CoV-2 ELISA positive Croatian SOTRs developed NT antibodies indicating protective immunity. Further studies are needed to determine the dynamic of NT antibodies and COVID-19 immunity duration in immunocompromised populations such as LTRs and KTRs. 相似文献
6.
此次新冠肺炎疫情传播速度快、影响范围广、防控难度大,在没有特异性治疗药物和疫苗的情况下,我国通过最全面彻底的、以"非医疗干预"手段为主的防控举措,全社会动员,全民参与,科学防治、精准防治,有效遏制了本土疫情,取得了阶段性重要成效。在此次疫情防控中,我国各级公共卫生与疾病预防控制(以下简称"疾控")体系起到了重要作用,但也暴露出了诸多短板和不足。文章梳理了现阶段我国疾控体系、公共卫生法律法规建设、卫生应急管理政策保障3个方面存在的突出问题,提出了新时代疾控体系的职能任务发展、关键科研技术建设和专业人才资源储备3个方面的具体建议。 相似文献
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"心理台风眼效应"描述了民众在重大突发事件中的非理性恐慌心理和行为,是中国科学院心理研究所李纾及其团队在"5·12"汶川特大地震后发现并命名的现象。在2020年新冠肺炎疫情期间,调查身居5类疫情不同风险地区(极低风险地区、低风险地区、中风险地区、中高风险地区和高风险地区)的人群对于武汉市疫情的安全担忧和风险知觉,又发现了"心理台风眼效应",即:国外受测者反而比国内受测者对武汉市疫情表现出更多的安全担忧或害怕;随着所处地区风险水平的升高(从极低风险地区到极高风险地区),民众对武汉市疫情的风险知觉反而降低。也就是说,在空间上越接近高风险地点的民众心理越平静,越远离高风险地点的民众反而更对高风险地点的风险感到恐慌。基于"心理台风眼效应"的研究发现,提出4条有针对性的防范建议。 相似文献
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Anita Somborac Ba
ura Marija Doroti&#x; Leonarda Gro&#x;i&#x; Monika Dimbeg Slavica Dodig 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(2)
Early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diagnosis of coronavirus disease 2019 (COVID-19) are priorities during the pandemic. Symptomatic and suspected asymptomatic individuals should be tested for COVID-19 to confirm infection and to be excluded from social interactions. As molecular testing capacity is overloaded during the pandemic, rapid antigen tests, such as lateral flow immunoassays (LFIAs), can be a useful tool as they allow greater test availability and obtain results in a very short time. This short review aims to present the analytical properties of LFIAs in the detection of SARS-CoV-2 in nasopharyngeal swabs. Lateral flow immunoassay is a method that combines thin-layer chromatography and indirect immunochemical sandwich method and allows the detection of a specific SARS-CoV-2 antigen in nasopharyngeal swabs. Swab specimens should be adequately collected and tested as soon as possible. Users should pay attention to quality control and possible interferences. Antigen tests for SARS-CoV-2 show high sensitivity and specificity in cases with high viral loads, and should be used up to five days after the onset of the first symptoms of COVID-19. False positive results may be obtained when screening large populations with a low prevalence of COVID-19 infection, while false negative results may happen due to improper specimen collection or insufficient amount of antigen in the specimen. So as to achieve reliable results, a diagnostic accuracy study of a specific rapid antigen test should be performed. 相似文献
10.
2019年底暴发的新冠肺炎疫情是一次重大的公共卫生事件,它对我国乃至世界的社会经济都将产生巨大而深远的影响。遗憾的是,这样的事件已不再是百年一遇,而是十年一遇或更短的时间,因此如何有效地应对大规模传染性疾病的暴发是人类社会面临的十分重要而迫切的问题。这次新冠肺炎疫情既是一个不幸,也是一个难得的学习机会。通过对疫情防控过程的回顾,以及对在该过程中所遇到的一些困难的梳理,发现很多问题最终都可以归结为供需矛盾的问题,而供给侧的挑战通常又都源于供应链的无序和混乱。文章结合现代供应链管理理论的一些基本原理,对疫情防控工作进行了分析并给出了建议,如建立全国联网传染病监测中心、国家防控战略物资安全库存、国家突发事件应急管理指挥中心等。另外,疫后经济重建也至关重要,因此还从供应链思维的角度,分析了新冠肺炎疫情的行业影响,以及企业复工复产过程中应该注意的事项。 相似文献
11.
【目的/意义】通过对微博数据的挖掘,了解公众的态度和需求,为新冠疫苗后续的推广或其他疫苗的推广
提供一定的参考。【方法/过程】基于内容分析法对564条微博热搜词条进行分类编码,得出公众广泛关注的10大主
题。将BTM主题模型和关联规则相结合,进一步对主题包含的热搜话题下的推文和评论进行挖掘,更详细地了解
公众的态度和需求。【结果/结论】公众对我国新冠疫苗的态度总体上是积极的,公众最关注的问题为新冠疫苗的不
良反应情况、接种禁忌、保护效果。【创新/局限】本研究的创新点在于通过微博平台热搜数据的主题发现研究,分析
了公众对新冠疫苗的态度和需求。 相似文献
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自2019年12月以来,湖北省武汉市出现新型冠状病毒肺炎(简称"新冠肺炎"),随后疫情在全国范围内暴发。相关学者对此次疫情扩散趋势做了大量研究,但基于模型的估算普遍存在高估传染系数和感染人群的问题。基于此,利用大数据回溯新冠肺炎在全国扩散的趋势和传染系数,得出结论:(1)在扩散前期(2020年1月24号之前)武汉输出的人口是全国各城市(武汉除外)新冠肺炎扩散的主要威胁,之后每个省、自治区、直辖市的人口与确诊病例数的关系逐渐增强,体现出本地传播的趋势;(2)利用SEIR模型拟合武汉和北京两地新冠肺炎确诊病例得出真实传播系数(R_0),揭示武汉的R0高于北京,考虑到人为控制因素,2019年12月1日—2020年2月9日两地的实际的R_0均大幅度下降。基于此,对疫情期间存在的问题进行针对性建议,并从数据上论证了中国政府对于疫情扩散强有力的控制能力,对阻止国内及世界范围的疫情扩散作出积极贡献。 相似文献
14.
《Information processing & management》2022,59(1):102796
In the period of Corona Virus Disease 2019 (COVID-19), millions of people participate in the discussion of COVID-19 on the Internet, which can easily trigger public opinion and threaten social stability. This paper creatively proposes a multi-stage risk grading model of Internet public opinion for public health emergencies. On the basis of general public opinion risk grading analysis, the model continuously pays attention to the risk level of Internet public opinion based on the time scale of regular or major information updates. This model combines Analytic Hierarchy Process Sort II (AHPSort II) and Swing Weighting (SW) methods and proposes a new Multi-Criteria Decision Making (MCDM) method – AHPSort II-SW. Intuitionistic fuzzy number and linguistic fuzzy number are introduced into the model to evaluate the criteria that cannot be quantified. The multi-stage model is tested using more than 2,000 textual data about COVID-19 collected from Microblog, a leading social media platform in China. Seven public opinion risk assessments were conducted from January 23 to April 8, 2020. The empirical results show that in the early COVID-19 outbreak, the risk of public opinion is more serious on macroscopic view. In details, the risk of public opinion decreases slowly with time, but the emergence of important events may still increase the risk of public opinion. The analysis results are in line with the actual situation and verify the effectiveness of the method. Comparative analysis indicates the improved method is proved to be superior and effective, sensitivity analysis confirms its stability. Finally, management suggestions was provided, this study contributes to the literature on public opinion risk assessment and provides implications for practice. 相似文献
15.
Scholars have highlighted the role of Digital Technologies (DT) in enhancing productivity and performance in Small and Medium Enterprises (SMEs). However, there is limited evidence on the use of DT for dealing with the consequences of extreme events, such as COVID-19. We discuss this gap by (i) outlining potential research avenues and (ii) reflecting on the managerial implications of using DT within SMEs to deal with the repercussions of COVID-19 and securing business continuity. 相似文献
16.
[目的/意义]重大突发事件对提高国家社会治理能力提出了新的要求,提升网络舆情态势评估能力成为创新社会治理的重要内容。[方法/过程]该文从网络舆情事件特征、关注度、传播扩散度及网民观点倾向等方面构建网络舆情态势评估指标,利用贝叶斯网络构建网络舆情态势评估模型,以“新冠肺炎疫情”事件为例,对网络舆情态势进行评估分析。[结果/结论]通过对网络舆情事件的测试,本文提出的方法具有较好的舆情态势评估效能,对“新冠肺炎疫情”相关网络舆情治理提出了建议。 相似文献
17.
[目的/意义]微博作为一种重要的信息传播载体,在疫情信息发布与传播中发挥着重要作用。深入分析疫情信息中蕴含的疫情事件及其对网民情绪的影响,有助于各级政府准确掌握网络舆论情况,科学高效地做好防控宣传和舆情引导工作。[方法/过程]以新冠肺炎疫情相关的微博新闻及其评论作为研究对象,利用条件随机场(Conditional Random Field,CRF)模型从微博新闻中抽取疫情事件并建立疫情事件画像;在情感词典的基础上,引入双向长短期记忆网络(Bidirectional Long Short-Term Memory,Bi-LSTM)模型建立网民情绪画像;利用基于自注意力机制的Bi-LSTM模型对疫情事件与网民情绪进行关联分析。[结果/结论]真实语料集上的实验结果表明,围绕捐资、防控、临床和英雄等主题,CRF模型疫情事件抽取的F值均达到73%以上,Bi-LSTM模型网民情绪识别的F值均在70%以上,基于注意力机制的Bi-LSTM模型给出的网民情绪分布基本符合疫情发展态势。 相似文献
18.
Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin 《国家科学评论(英文版)》2021,8(3)
Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2. Halting these steps can cure COVID-19. Here we have identified and characterized a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Remarkably, HB27 can also prevent SARS-CoV-2 membrane fusion. Consequently, a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models. Rhesus macaques showed no obvious adverse events when administrated with 10 times the effective dose of HB27. Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor. Binding of the antibody also restrains any further conformational changes of the receptor binding domain, possibly interfering with progression from the prefusion to the postfusion stage. These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19. 相似文献
19.
Jasna Lenicek Krleza Renata Zrinski Topic Vladimir Stevanovic Amarela Lukic-Grlic Irena Tabain Zrinjka Misak Goran Roic Bernard Kaic Dijana Mayer Zeljka Hruskar Ljubo Barbic Tatjana Vilibic-Cavlek 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(2)
IntroductionThe study aimed to investigate the prevalence and titres of anti-SARS-CoV-2 antibodies in children treated at the Children’s Hospital Zagreb in the first and the second wave of the COVID-19 pandemic. Statistical significance of difference at two time points was done to determine how restrictive epidemiological measures and exposure of children to COVID-19 infection affect this prevalence in different age groups.Materials and methodsAt the first time point (13th to 29th May 2020), 240 samples and in second time point (24th October to 23rd November 2020), 308 serum samples were tested for anti-SARS-CoV-2 antibodies by enzyme-linked immunosorbent assay (ELISA) and electrochemiluminescence immunoassay (ECLIA). Confirmation of results and titre determination was done using virus micro-neutralization test. Subjects were divided according to gender, age and epidemiological history.ResultsSeroprevalence of anti-SARS-CoV-2 antibodies differs significantly in two time points (P = 0.010). In first time point 2.9% of seropositive children were determined and in second time point 8.4%. Statistically significant difference (P = 0.007) of seroprevalence between two time points was found only in a group of children aged 11-19 years. At the first time point, all seropositive children were asymptomatic with titre < 8. At the second time point, 69.2% seropositive children were asymptomatic with titre ≥ 8.ConclusionsThe prevalence of anti-SARS-CoV-2 antibodies was significantly lower at the first time point than at the second time point. Values of virus micro-neutralization test showed that low titre in asymptomatic children was not protective at the first time point but in second time point all seropositive children had protective titre of anti-SARS-CoV-2 antibodies. 相似文献
20.
新冠肺炎疫情短期内严重冲击了我国生产供应,加大了国内产业链加速外移的风险。文章基于当前疫情导致我国短期生产与出口供给缺口的研究,结合我国在全球生产网络和亚洲生产链的枢纽位置,就疫情对全球产业链的冲击及其引发的我国产业链加速外移风险进行了剖析。研究结果表明,疫情引起的产能缺口将对全球生产体系产生冲击,跨国企业将加快生产链布局调整,需密切关注疫情造成部分产业链加速外移的风险。最后,就企业复工保障、疫情防控和产业链布局等方面提出相关政策建议。 相似文献