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Ramesh Chander Farhan Rizvi A. K Khanna Ram Pratap 《Indian journal of clinical biochemistry : IJCB》2003,18(2):71-79
Guggulsterone, a mixture of cis (E) and trans (Z) isomers (7∶3 w/w) was synthesized from 16-DPA. The isomers were separated
by column chromatography and evaluated for cardioprotective and antioxidant activities. Myocardial necrosis induced by isoproterenol
in rats caused marked increase in serum creatine phosphokinase and glutamate pyruvate transaminase. Simultaneously in ischemic
heart, phospholipase, xanthine oxidase and lipid peroxides were enhanced following depletion of glycogen, phospholipids and
cholesterol. Treatment with guggulsterone and its both isomers at the dose of 50 mg/kg po., significantly protected cardiac
damage as assessed by the reversal of blood and heart biochemical parameters in ischemic rats. The cardioprotective activity
of guggulsterone and of both the isomers were compared with that of gemfibrozil at the same doses. Guggulsterone and both
the isomers at tested concentrations (5–20mM) inhibited oxidative degradation of lipids in human low-density lipoprotein and
rat liver microsomes induced by metal ionsin vitro. The drug counteracted against the generation of superoxide anions (O2) and hydroxyl radicals (OH−) in non-enzymic test systems. It is suggested that cardioprotective and antioxidant activities of synthetic guggulsterone
and guggulsterone obtained from gum resinCommiphora mukul that contains isomers E & Z in the ratio of 46∶54w/w are the same. 相似文献
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Educational Psychology Review - In their recent paper, Chen et al. (Educational Psychology Review, 2021) propose that rest periods between deliberate learning characterize the spacing effect and... 相似文献
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Farhana Zahir Shameem J Rizvi Soghra K Haq Rizwan H Khan 《Indian journal of clinical biochemistry : IJCB》2006,21(2):149-152
Mercury pollution and acute neurotoxicity of mercury is well known. The recent reports suggest the adverse effect of low dose
mercury, though the available literature is still silent on its mechanism. This study was therefore undertaken to probe the
effect of low dose methyl mercury induced heavy metal toxicity on free radical stress and its impact on behaviour of male
albino rats. Male albino rats were exposed to 1 mg/kg body wt of methylmercury chloride for seven days, on day 8 they were
tested for motor and memory functions. They were sacrificed later for biochemical estimations for rate of lipid peroxidation,
nucleic acids, proteins in cerebrum, cerebellum and brain stem. There was an increase in the rate of lipid peroxidation showing
methyl mercury induced free radical stress. The motor and memory functions demonstrated a clear decline, besides there was
a lowering in the levels of nucleic acids and proteins as compared to controls. The results are important in view of recent
reports that methyl mercury induced free radical stress results in early ageing and may serve as an initiating factor more
specifically for neurodegenerative disorders like Alzeihemer's disease and dementias. The current findings support the notion
that incorporating dietary antioxidants like curcumin, ascorbic acid and α-tocopherol in routine diet from early age may help
combat the risk of developing such disorders in ensuing years. 相似文献
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The correlation between antioxidant capacity and oxidative damage during aging has been reported in several tissues in different
species. Glutathione-S-transferases (GST) can metabolise endogenous and exogenous toxins and carcinogens by catalysing the
conjugation of diverse electrophiles with reduced glutathione (GSH). We observe a significant (P < 0.001) increase in plasma GST activity as a function of human age (r = 0.5675). A significant (P < 0.001) positive correlation (r = 0.8979) is observed between GST activity and total plasma antioxidant potential measured
as ferric reducing ability of the plasma (FRAP). GST activity and red cell intracellular GSH also show a significant positive
correlation (r = 0.7014). We hypothesize that the increased activity of plasma GST is a manifestation of increased generation
of ROS and a concomitant decrease in the level of plasma antioxidant capacity during aging. 相似文献
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The contribution of Arab universities to the public good is being greatly compromised by the political and economic instability of the Arab Spring. To understand the role Arabian universities are playing in the public sphere and their ability to contribute to the public good, we interviewed 74 professors from 14 countries. Analysis of the faculty interviews yielded four major challenges: motivation and rewards for conducting research, security and safety issues, lack of a research infrastructure, and the challenges of international recognition. Our findings suggest universities should focus on the two most critical issues over which they have some control: securing safety for the faculty and creating an effective research infrastructure. 相似文献
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GLOBALIZATION AND EDUCATION: COMPLEXITIES AND CONTINGENCIES 总被引：3，自引：0，他引：3
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Fazal Rizvi 《The Australian Educational Researcher》1997,24(1):13-26