排序方式： 共有5条查询结果，搜索用时 31 毫秒
1
1.
2.
3.
5-Fluorouracil (5-FU) has a broad spectrum of anti-tumor activity, widely applied to the treatment of cancers. However, it is necessary to determine the plasma concentration of 5-FU in clinical practice due to its narrow therapeutic index. Therefore, a simple, economic and sensitive high-performance liquid chromatography (HPLC) method was developed and validated for the determination of 5-FU in human plasma. Ethyl acetate was chosen as extraction reagent. Chromatographic separation was performed on a Diamonsil C18 column (250 mm × 4.6 mm i.d., 5 μm) with the mobile phase consisting of methanol and 20 mmol/L ammonium formate using a linear gradient elution at a flow rate of 0.8 mL/min. 5-FU and 5-bromouracil (5-BU) were detected by UV detector at 265 nm. The calibration curve was linear over the concentration range of 5—500 ng/mL and the correlation coefficient was not less than 0.992 6 for all calibration curves. The intra- and inter-day precisions were less than 10.5% and 4.3%, respectively, and the accuracy was within ±3.7%. The recovery at all concentration levels was 80.1±8.6%. 5-FU was stable under possible conditions of storing and handling. This method is proved applicable to therapeutic drug monitoring and pharmacokinetic studies of 5-FU in human. 相似文献
4.
1 Ｉｎｔｒｏｄｕｃｔｉｏｎ Ｉｎｅｃｏｌｏｇｙ ,ａｐｒｅｄａｔｏｒ ｐｒｅｙｉｎｔｅｒａｃｔｉｏｎｏｆｂｏｔｈｐｏｐｕ ｌａｔｉｏｎｓｉｎｏｎｅｄｉｍｅｎｓｉｏｎｉｓｄｅｓｃｒｉｂｅｄｂｙｔｈｅｆｏｌｌｏｗｉｎｇｓｙｓｔｅｍ[1] :ｕｔ(ｘ ,ｔ) =ｕｘｘ ｕＭ (ｕ ,ｖ) ,ｖｔ(ｘ ,ｔ) =βｖｘｘ ｖＮ(ｕ ,ｖ) ,(1)ｗｈｅｒｅβｉｓａｐｏｓｉｔｉｖｅｃｏｎｓｔａｎｔ,ｕａｎｄｖａｒｅｔｈｅｐｒｅｙａｎｄｐｒｅｄａｔｏｒｄｅｎｓｉｔｉｅｓｒｅｓｐｅｃｔｉｖｅｌｙ ,ａｎｄｔｈｅｆｕｎｃｔｉｏｎｓＭａｎｄＮａｒｅ… 相似文献
5.
谷元 《中国科教创新导刊》1996,(1)
下一代光盘谷元译章启校自从光盘（ＣＤ）最初被研制出后，许多公司一直都在寻求改进其格式的途径。他们现在认为已经找到了答案。正当你认为值得在ＣＤ放象机上大把花钱的时候，全新的一代ＣＤ已经即将问世了。欧洲与日本的几家电子巨人经过了一年的秘密谈判即将推出高密... 相似文献
1