大鼠帕金森氏病动物模型的建立   总被引：2，自引：0，他引：2  

郑杰胜  郑树森  詹仁雅  周永庆  许德华  张家兴 《科技通报》2001,17(6):80-83

采用SD大鼠30只，25只为试验组，5只为对照组。在三维立体定向仪上用微量注射器将6－OHDA32μg分两点注射入右侧纹状体，每周检测动物的旋转行为，第1周动物没有出现旋转行为，第2周动物出现明显的旋转行为，随后缓慢上升；至术后5周才升至较高的水平并保持平稳。其中有15只动物达到或超过了7r/min这一通常采用的标准，模型成功率达60％。酪氨酸羟化酶免疫组化显示：术后第1周至第5周右侧黑质TH免疫反应细胞逐渐砬少，各个时期的右侧黑质TH免疫反应细胞较对侧明显减少。采用此方法建立的大鼠帕金森氏病模型更加符合临床PD病人的病程进展并明显提高成功率。  相似文献   

Phenotypic and functional characteristics of dendritic cells derived from human peripheral blood monocytes   总被引：4，自引：0，他引：4  

汤灵玲  张哲  郑杰胜  盛吉芳  刘克洲 《Journal of Zhejiang University. Science. B》2005,6(12):1176-1181

INTRODUCTION Dendritic cells(DCs)are professional anti-gen-presenting cells(APC)that are responsible for the activation of undifferentiated T cells and the generation of primary T-cell responses(Cella et al.,1997).The specific role of DCs is to capture,process and present antigens to T cells.Immunogenic and inflammatory signals are responsible for the migra-tion of DCs from tissues to lymphoid organs where they initiate an immune response.These processes induce the maturation of DCs…  相似文献