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1.
Mala Mahto Baidarbhi Chakraborthy Srinivas H. Gowda Harneet Kaur Gaurav Vishnoi Pramod Lali 《Indian journal of clinical biochemistry : IJCB》2012,27(3):284-289
The implications of subclinical hypothyroidism (SCH) are many amongst which the most important is progression to overt hypothyroidism. Other debatable aspects are its association with cardiovascular risk, neuromuscular and psychiatric dysfunction, increased predisposition to developing metabolic syndrome and an underlying pro-inflammatory state. We aimed to study the lipid profile, lipoprotein(a) [Lp(a)] and hsCRP levels and insulin resistance in a group of patients with SCH in a referral hospital and see if any significant differences exist between them and euthyroids. This is a case–control study where the selection of controls and cases was based on the thyroid profile. Subjects were selected on their visit to clinical biochemistry lab for thyroid function tests. 33 euthyroids were taken as controls (Group I) and 38 patients comprising of subclinical hypothyroids were grouped as cases (Group II). Serum thyroid stimulating hormone (TSH) was in the range of 0.5–5.0 mIU/L for euthyroids and for subclinical hypothyroids the concentration of TSH was more than 5 mIU/L. The concentration of tri-iodothyronine (T3) and thyroxine (T4) were in normal reference range in both the groups. Individual lipid profile parameters failed to show a significant p value between cases and controls. The LDL/HDL ratio was highly significant (p value < 0.0001) and hsCRP was also statistically between the two groups (p value = 0.0054). Lp(a) and insulin resistance did not differ significantly. SCH is a common disorder that frequently progresses to overt hypothyroidism. This study underlines the importance of LDL/HDL ratio rather than measurement of individual lipid profile parameters in bringing to light the dyslipidemic state associated with SCH. Moreover the use of hsCRP to detect an underlying pro-inflammatory state in SCH can also be emphasized. 相似文献
2.
Gaurav Chikara Pramod Kumar Sharma Pradeep Dwivedi Jaykaran Charan Sneha Ambwani Surjit Singh 《Indian journal of clinical biochemistry : IJCB》2018,33(2):121-131
Prevalence of diabetes mellitus, a chronic metabolic disease characterized by hyperglycemia, is growing worldwide. The majority of the cases belong to type 2 diabetes mellitus (T2DM). Globally, India ranks second in terms of diabetes prevalence among adults. Currently available classes of therapeutic agents are used alone or in combinations but seldom achieve treatment targets. Diverse pathophysiology and the need of therapeutic agents with more favourable pharmacokinetic-pharmacodynamics profile make newer drug discoveries in the field of T2DM essential. A large number of molecules, some with novel mechanisms, are in pipeline. The essence of this review is to track and discuss these potential agents, based on their developmental stages, especially those in phase 3 or phase 2. Unique molecules are being developed for existing drug classes like insulins, DPP-4 inhibitors, GLP-1 analogues; and under newer classes like dual/pan PPAR agonists, dual SGLT1/SGLT2 inhibitors, glimins, anti-inflammatory agents, glucokinase activators, G-protein coupled receptor agonists, hybrid peptide agonists, apical sodium-dependent bile acid transporter (ASBT) inhibitors, glucagon receptor antagonists etc. The heterogeneous clinical presentation and therapeutic outcomes in phenotypically similar patients is a clue to think beyond the standard treatment strategy. 相似文献
3.
Subir Kumar Das Sukhes Mukherjee Gaurav Pandey V. Balakrishnan D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(2):155-158
Non-alcoholic fatty liver disease and its more aggressive form, non-alcoholic steatohepatitis are entities that are becoming
more and more interesting to the medical community in general. A total of 93 Non-alcoholic fatty liver disease patients (64
male and 29 female) within the age range between 28 to 63 years were studied. All of them showed elevated alanine aminotransferase
level (104.07 ± 56.04). Aspartate aminotransferase level (58.13 ± 31.96) was elevated more than its normal level in 82% cases
and AST to ALT ratio was found 0.59 ± 0.26. Predisposing factors were diabetes mellitus (37%), obesity (13%) and hyperlipidemia
(41%). In addition, 32% of the subjects were overweight.18% of the patients had elevated serum bilirubin. Our findings recommend
a lower cutoff value than suggested by the World Health Organization for overweight and obesity among this racial-ethnic group. 相似文献
4.
Kimberly Ann Clevenger Gaurav Sinha Cheryl A. Howe 《Measurement in physical education and exercise science》2019,23(1):58-68
Several geospatial approaches have been used to characterize physical activity during recess using global positioning system (GPS) data. GPS and accelerometer data from 23 children collected during recess were analyzed using four previously used approaches: (1) dot map, (2) fishnet grid, (3) hot spot analysis, which determines clusters of high/low intensity values, and (4) zonal approach wherein the schoolyard was divided into zones to determine the time and intensity in each zone. Results from each method were compared to each other and to video observation. Hot spot analysis revealed clusters of high-intensity values, which were supported by dot and grid maps and video. However, the zonal approach revealedpatterns in where children play that were not always comparable tovideo, potentially due to missing GPS data. Recommendations for the use of these methods in future research are discussed. 相似文献
5.
Despite having outlawed the caste system and the concept of untouchability in 1947, caste identity remains a cornerstone of social, political and economic life in India. Like other social institutions, educational institutions are the reflection of caste prejudices and discrimination. The recent inclusion of lower castes through the reservation system (affirmative action) has changed the nature of higher education. Based on an ethnographic account of a university campus and students’ perceptions about caste issues, the authors suggest that the structure of higher education in India is designed in a manner that exacerbates, instead of ameliorates, tensions of class and caste. Using Bourdieu’s notion of cultural capital, the paper defines the existing campus culture as a ‘caste culture’. The text concludes that elite institutions do not yet guarantee the capability to overcome existing caste prejudices and stereotypes, regardless of structural attempts at reform.
相似文献6.
S. V. Rana Aastha Malik Sanjay K. Bhadada Naresh Sachdeva Rajesh Kumar Morya Gaurav Sharma 《Indian journal of clinical biochemistry : IJCB》2017,32(1):84-89
Type 2 diabetes mellitus consists of dysfunctions characterized by hyperglycemia and resulting from combination of resistance to insulin action and inadequate insulin secretion. Most of diabetic patients report significant gastrointestinal symptoms. Entire GI tract can be affected by diabetes from oral cavity to large bowel and anorectal region. Proteins, carbohydrates, fats, and most fluids are absorbed in small intestine. Malabsorption may occurs when proper absorption of nutrients does not take place due to bacterial overgrowth or altered gut motility. The present study was planned to measure various malabsorption parameters in type 2 diabetic patients. 175 patients and 175 age and sex matched healthy controls attending Endocrinology Clinic in PGI, Chandigarh were enrolled. Lactose intolerance was measured by using non-invasive lactose hydrogen breath test. Urinary d-xylose and fecal fat were estimated using standard methods. Orocecal transit time and small intestinal bacterial overgrowth were measured using non-invasive lactulose and glucose breath test respectively. Out of 175 diabetic patients enrolled, 87 were males while among 175 healthy subjects 88 were males. SIBO was observed in 14.8 % type 2 diabetic patients and in 2.8 % of controls. There was statistically significant increase (p < 0.002) in OCTT in type 2 diabetic patients compared with controls. OCTT was observed to be more delayed (p < 0.003) in patients who were found to have SIBO than in patients without SIBO. Lactose intolerance was observed in 60 % diabetic patients and 39.4 % in controls. Urinary d-xylose levels were also lower in case of diabetic patients but no significant difference was found in 72 h fecal fat excretion among diabetic patients and controls. Urinary d-xylose and lactose intolerance in SIBO positive type 2 diabetic patients was more severe as compared to SIBO negative diabetic patients. From this study we can conclude that delayed OCTT may have led to SIBO which may have instigated the process of malabsorption among type 2 diabetic patients. 相似文献
7.
Harshini Sriram Twinkle Khanka Shweta Kedia Priyanka Tyagi Sitaram Ghogale Nilesh Deshpande Gaurav Chatterjee Sweta Rajpal Nikhil V Patkar Papagudi G Subramanian Sumeet Gujral Syed Hasan Prashant R Tembhare 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(3)
IntroductionMicroRNAs are small, non-coding RNA molecules that are becoming popular biomarkers in several diseases. However, their low abundance in serum/plasma poses a challenge in exploiting their potential in clinics. Several commercial kits are available for rapid isolation of microRNA from plasma. However, reports guiding the selection of appropriate kits to study downstream assays are scarce. Hence, we compared four commercial kits to evaluate microRNA-extraction from plasma and provided a modified protocol that further improved the superior kit’s performance.Materials and methodsWe compared four kits (miRNeasy Serum/Plasma, miRNeasy Mini Kit from Qiagen; RNA-isolation, and Absolutely-RNA MicroRNA Kit from Agilent technologies) for quality and quantity of microRNA isolated, extraction efficiency, and cost-effectiveness. Bioanalyzer-based Agilent Small RNA kit was used to evaluate quality and quantity of microRNA. Extraction efficiency was evaluated by detection of four endogenous control microRNA using real-time-PCR. Further, we modified the manufacturer’s protocol for miRNeasy Serum/Plasma kit to improve yield.ResultsmiRNeasy Serum/Plasma kit outperformed the other three kits in microRNA-quality (P < 0.005) and yielded maximum microRNA-quantity. Recovery of endogenous control microRNA i.e. hsa-miR-24-3p, hsa-miR-191-5p, hsa-miR-423-5p and hsa-miR-484 was higher as well. Modification with the inclusion of a double elution step enhanced yield of microRNA extracted with miRNeasy Serum/Plasma kit significantly (P < 0.001).ConclusionWe demonstrated that miRNeasy Serum/Plasma kit outperforms other kits and can be reliably used with a limited plasma quantity. We have provided a modified microRNA-extraction protocol with improved microRNA output for downstream analyses. 相似文献
8.
Satinder Kaur Parminder Singh Verma Indu Gaurav Singla 《Indian journal of clinical biochemistry : IJCB》2012,27(1):94-96
The present work was undertaken to study interrelation of Fibrinogen, Lp(a) and LVMI in Type II diabetes patients with or
without nephropathy. 100 Type II Diabetic patients attending OPD/IPD of DMC&H, Ludhiana were included. They were divided in
two groups. Group I: 50 patients without microalbuminuria (MAU). Group II: 50 patients with MAU. Fibrinogen (Clauss method),
Lp(a) and MAU were estimated on Multichannel Autoanalyzer Hitachi-911 (Roche). LVMI was estimated by echocardiography using
formula of Devereux and Reicheck. Type II diabetes patients with MAU had significantly raised levels of Fibrinogen, Lp(a),
and LVMI as compared to normoalbuminuric diabetics (P < 0.01). Group II patients had positive correlation between Lp(a) and LVMI but no relation between Fibrinogen and LVMI. MAU,
marker of microangiopathy, is associated with higher Fibrinogen and Lp(a) levels. This becomes basis of increase cardiovascular
risk as demonstrated by higher mean LVMI in Group II patients. 相似文献
9.
Gaurav Pandey Zhaochun Ren Shuaiqiang Wang Jari Veijalainen Maarten de Rijke 《Information Retrieval》2018,21(6):481-506
We address the feature extraction problem for document ranking in information retrieval. We then propose LifeRank, a Linear feature extraction algorithm for Ranking. In LifeRank, we regard each document collection for ranking as a matrix, referred to as the original matrix. We try to optimize a transformation matrix, so that a new matrix (dataset) can be generated as the product of the original matrix and a transformation matrix. The transformation matrix projects high-dimensional document vectors into lower dimensions. Theoretically, there could be very large transformation matrices, each leading to a new generated matrix. In LifeRank, we produce a transformation matrix so that the generated new matrix can match the learning to rank problem. Extensive experiments on benchmark datasets show the performance gains of LifeRank in comparison with state-of-the-art feature selection algorithms. 相似文献
10.