Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

An analysis of review content and reviewer variables that contribute to review helpfulness     

MSI Malik  Ayyaz Hussain 《Information processing & management》2018,54(1):88-104

Review helpfulness is attracting increasing attention of practitioners and academics. It helps in reducing risks and uncertainty faced by users in online shopping. This study examines uninvestigated variables by looking at not only the review characteristics but also important indicators of reviewers. Several significant review content and two reviewer variables are proposed and an effective review helpfulness prediction model is built using stochastic gradient boosting learning method. This study derived a mechanism to extract novel review content variables from review text. Six popular machine learning models and three real-life Amazon review data sets are used for analysis. Our results are robust to several product categories and along three Amazon review data sets. The results show that review content variables deliver the best performance as compared to the reviewer and state-of-the-art baseline as a standalone model. This study finds that reviewer helpfulness per day and syllables in review text strongly relates to review helpfulness. Moreover, the number of space, aux verb, drives words in review text and productivity score of a reviewer are also effective predictors of review helpfulness. The findings will help customers to write better reviews, help retailers to manage their websites intelligently and aid customers in their product purchasing decisions.  相似文献   

Strategies for publishing in English journals: A study of the perceptions of Iranian scholars          下载免费PDF全文

Mahmood Maniati  Alireza Jalilifar 《Learned Publishing》2018,31(4):355-365

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Anatomical studies on water hyacinth (Eichhornia crassipes (Mart.) Solms) under the influence of textile wastewater     

Mahmood Q  Siddiqi MR  Islam Eu  Azim MR  Zheng P  Hayat Y 《Journal of Zhejiang University. Science. B》2005,6(10):991-998

Water hyacinth (Eichhornia crassipes (Mart.) Solms) is a prolific free floating aquatic macrohpyte found in tropical and subtropical parts of the earth. The effects of pollutants from textile wastewater on the anatomy of the plant were studied. Water hyacinth exhibits hydrophytic adaptations which include reduced epidermis cells lacking cuticle in most cases, presence of large air spaces (7∼50 μm), reduced vascular tissue and absorbing structures. Textile waste significantly affected the size of root cells. The presence of raphide crystals was noted in parenchyma cells of various organs in treated plants. Project (No. 30070017) supported by the National Natural Science Foundation of China  相似文献   

Modelling parenting styles,moral intelligence,academic self-efficacy and learning motivation among adolescents in grades 7–11     

Amal Alhadabi  Said Aldhafri  Hussain Alkharusi  Ibrahim Al-Harthy  Marwa Alrajhi  Hafidha AlBarashdi 《Asia Pacific Journal of Education》2019,39(1):133-153

The current study investigated the associations between three maternal and paternal parenting styles, moral intelligence, academic self-efficacy and learning motivation in three serial mediation models. Omani adolescents enrolled in 7th to 11th grades (N = 296) responded to an online survey containing demographic items and scales measuring the variables noted above. Results of Path Analysis indicated that the three models had a good overall fit. In detail, the three paternal styles (authoritative, authoritarian and permissive) had direct associations with moral intelligence and indirect associations with learning motivation. However, only two maternal parenting styles (i.e., authoritative and authoritarian) correlated directly with learning motivation and these two styles did not associate with moral intelligence. All effects were in the hypothesized direction except the effect of authoritative maternal and paternal styles. Moral intelligence had a positive direct correlation with students’ academic self-efficacy and learning motivation. Moral intelligence also mediated the negative associations between three types of fathers’ parenting styles and students’ motivation. Academic self-efficacy had a positive association with students’ motivation. These findings provided useful insights about the various association between external factors (e.g., parenting styles), internal factors (i.e., moral intelligence and self-efficacy) and students’ motivation among adolescents in middle and high schools.  相似文献   

Expert group formation using facility location analysis     

Mahmood Neshati  Hamid Beigy  Djoerd Hiemstra 《Information processing & management》2014

In this paper, we propose an optimization framework to retrieve an optimal group of experts to perform a multi-aspect task. While a diverse set of skills are needed to perform a multi-aspect task, the group of assigned experts should be able to collectively cover all these required skills. We consider three types of multi-aspect expert group formation problems and propose a unified framework to solve these problems accurately and efficiently. The first problem is concerned with finding the top k experts for a given task, while the required skills of the task are implicitly described. In the second problem, the required skills of the tasks are explicitly described using some keywords but each expert has a limited capacity to perform these tasks and therefore should be assigned to a limited number of them. Finally, the third problem is the combination of the first and the second problems. Our proposed optimization framework is based on the Facility Location Analysis which is a well known branch of the Operation Research. In our experiments, we compare the accuracy and efficiency of the proposed framework with the state-of-the-art approaches for the group formation problems. The experiment results show the effectiveness of our proposed methods in comparison with state-of-the-art approaches.  相似文献   

Teaching in primary schools in China and India: contexts of learning     

Fatema Anis Hussain 《Asia Pacific Journal of Education》2017,37(1):132-134

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Poly A RNA status and expression of milli (m) and micro (μ) calpains in skeletal muscle of duchenne muscular dystrophy patients     

Harleen Mangat  Tajamul Hussain  C Sundaram  MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(2):74-79

Poly A RNA status and itsin vitro translation in a rabbit reticulolysate cell free system, were assessed in the skeletal muscle of young boys with Duchenne muscular dystrophy. Compared to normals there is a significant 48% increase in poly A RNA content of dystrophic muscle and its translatability was increased by 56% based on³⁵S methionine incorporation into total protein systhesised. Immunoprecipitation of the translated products with monospecific antibodies showed that there is a 2.6 fold and a 2 fold increase in m and μ calpains respectively. This underlines the importance of both synthetic and degenerative activities in the early pathology in DMD muscle.  相似文献   

Factors affecting the perceptions of Iranian agricultural researchers towards nanotechnology     

Hosseini SM  Rezaei R 《Public understanding of science (Bristol, England)》2011,20(4):513-524

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The role of English language and international media as agents of cultural globalisation and their impact on identity formation in Kuwait     

Mohammed M. Hasanen  Ali A. Al-Kandari  Hussain Al-Sharoufi 《Globalisation, Societies & Education》2014,12(4):542-563

This study examines the influence of English language usage and international media on the strength of either national or global identity. The regression analysis of 354 responses reveals that individuals who studied at universities that use English as a medium of instruction show significant differences in the extent to which they embrace a global identity. Viewing local (Kuwaiti) television programmes and the use of the Internet predict national identity. This study discusses the social entities that are important factors in mitigating the influence of globalisation on national identity. It concludes that the argument that globalisation and Westernisation are two faces of the same coin is overstated.  相似文献