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This paper draws attention to some questions thrown up by the increased circulation of mass-produced cultural commodities sourced from Asia in the relatively new markets of the region. Juxtaposing the short-lived success of the Indian star Rajnikant in Japan in the late 1990s and the unsuccessful attempt to promote Korean films in the Indian theatrical circuits a decade later, the paper argues that in spite of their considerable differences both instances foreground the difficulties cultural industries of Asia have in generating revenues in the region's markets. The paper goes on to elaborate on a model of stardom, exemplified by Rajnikant, which has evolved as a direct response to the challenges posed by low value markets.  相似文献   
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The implications of subclinical hypothyroidism (SCH) are many amongst which the most important is progression to overt hypothyroidism. Other debatable aspects are its association with cardiovascular risk, neuromuscular and psychiatric dysfunction, increased predisposition to developing metabolic syndrome and an underlying pro-inflammatory state. We aimed to study the lipid profile, lipoprotein(a) [Lp(a)] and hsCRP levels and insulin resistance in a group of patients with SCH in a referral hospital and see if any significant differences exist between them and euthyroids. This is a case–control study where the selection of controls and cases was based on the thyroid profile. Subjects were selected on their visit to clinical biochemistry lab for thyroid function tests. 33 euthyroids were taken as controls (Group I) and 38 patients comprising of subclinical hypothyroids were grouped as cases (Group II). Serum thyroid stimulating hormone (TSH) was in the range of 0.5–5.0 mIU/L for euthyroids and for subclinical hypothyroids the concentration of TSH was more than 5 mIU/L. The concentration of tri-iodothyronine (T3) and thyroxine (T4) were in normal reference range in both the groups. Individual lipid profile parameters failed to show a significant p value between cases and controls. The LDL/HDL ratio was highly significant (p value < 0.0001) and hsCRP was also statistically between the two groups (p value = 0.0054). Lp(a) and insulin resistance did not differ significantly. SCH is a common disorder that frequently progresses to overt hypothyroidism. This study underlines the importance of LDL/HDL ratio rather than measurement of individual lipid profile parameters in bringing to light the dyslipidemic state associated with SCH. Moreover the use of hsCRP to detect an underlying pro-inflammatory state in SCH can also be emphasized.  相似文献   
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Context

In this article we considered knowledge transfer (KT) in global software development (GSD) from two perspectives, state-of-the-art and state-of-the-practice, in order to identify what are the challenges that hamper the success of KT in global software teams, as well as to find out what are the mitigation strategies that can be used to overcome such challenges.

Objectives

The overall aim of this work is to provide a body of knowledge for enabling successful KT in GSD settings. This is achieved by an in-depth understanding of KT challenges and mitigation strategies, both from the perspective of literature and industry. It also identifies the similarities and differences in challenges and strategies gathered from literature studies and industrial experts.

Methods

In order to fulfill the aim of the research, we collected data through a systematic literature review (SLR) and conducted interviews with industrial experts. Through the SLR we found 35 primary studies relevant to our objectives. We also conducted eight interviews of experienced industrial professionals from eight different multinational companies world-wide. For analyzing the data we used grounded theory and cross-case analysis.

Results

In total, 60 different challenges and 79 unique mitigation strategies are identified from both SLR and interview results. The challenges and mitigation strategies are grouped into three core categories of personnel, project and technology factors, thus giving rise to a conceptualization called as 2PT factors. There are greater numbers of challenges and mitigation strategies in the project and personnel factors, highlighting the complex interplay of project-related and human-intensive issues in GSD projects, while the technology factor plays the role as facilitator in transferring knowledge. The study also maps the mitigation strategies to challenges, which can guide practitioners in their selection of strategies to use for overcoming KT challenges in GSD.

Conclusions

We conclude that effective management of project and personnel factors, facilitated by technological factors, are crucial for a successful transfer of knowledge in GSD projects. Thus in future, the researchers and practitioners need to focus on the 2PT factors for ensuring effective KT in GSD settings.  相似文献   
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The concept of smart tourism remains fuzzy when it comes to practice because of the lack of clarity on the roles and responsibilities of stakeholders in addition to complex institutional ecosystem that exist within the tourism industry. Further, trust and safety of the data generated due to the advancement of smart tourism in varied institutional arrangements pose huge challenges. Extant literature proposes that the application of decentralized ledger promises possible solutions to most of these problems due to the inherent features of the Blockchain technology. This suggestion raises two practical questions. First, does the sophisticated additional layer adds complexity to its practical application? Second, will the suggested solutions really lead to a win-win for all the stakeholders involved? In this study, we use Ostrom's action arena to examine the exchanges (information, contractual and monetary) between various stakeholders in a BCT enabled smart tourism of a Blockchain enabled tourism industry to answer these two questions.  相似文献   
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Assessment of the dielectrophoresis (DEP) cross-over frequency (fxo), cell diameter, and derivative membrane capacitance (Cm) values for a group of undifferentiated human embryonic stem cell (hESC) lines (H1, H9, RCM1, RH1), and for a transgenic subclone of H1 (T8) revealed that hESC lines could not be discriminated on their mean fxo and Cm values, the latter of which ranged from 14 to 20 mF/m2. Differentiation of H1 and H9 to a mesenchymal stem cell-like phenotype resulted in similar significant increases in mean Cm values to 41–49 mF/m2 in both lines (p < 0.0001). BMP4-induced differentiation of RCM1 to a trophoblast cell-like phenotype also resulted in a distinct and significant increase in mean Cm value to 28 mF/m2 (p < 0.0001). The progressive transition to a higher membrane capacitance was also evident after each passage of cell culture as H9 cells transitioned to a mesenchymal stem cell-like state induced by growth on a substrate of hyaluronan. These findings confirm the existence of distinctive parameters between undifferentiated and differentiating cells on which future application of dielectrophoresis in the context of hESC manufacturing can be based.  相似文献   
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Paraproteinemia is characterised by clonal proliferation of plasma cells. A common laboratory finding in paraproteinemia being a monoclonal peak in serum protein electrophoresis (M band). But there are factors which produce a peak similar to M spike in serum protein electrophoresis and these factors are known as pseudoparaproteins. This case report discusses a rare cause of pseudo M spike in a known case of autoimmune hemolytic anaemia due to administration of drug-Rituximab, a monoclonal antibody by itself.  相似文献   
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Sensitization to ingested foods is a known fact and several food allergens have been characterized. It has been observed in our survey that the people complained of allergic symptoms after consumption of the vegetableVigna sinensis. In this study, the experiments were carried to investigate the IgE antibody response against the green seed extract of vigna sinensis in mice and found that the primary, secondary and tertiary immunization with or without adjuvant by different doses induced a significant production of IgE antibodies. The presence of IgE antibodies in the mice sera were determined by passive cutaneous anaphylaxis and enzyme linked immunosorbent assay. It was also confirmed that these allergens were found to be heat resistant and shared a common epitope(s) with the other legume foods, as evidenced by the cross-reactive studies.  相似文献   
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