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Jonathan S. Jones Anna-Lynne R. Adlam Abdelmalek Benattayallah Fraser N. Milton 《Child development》2022,93(3):815-830
Working memory training improves children's cognitive performance on untrained tasks; however, little is known about the underlying neural mechanisms. This was investigated in 32 typically developing children aged 10–14 years (19 girls and 13 boys) using a randomized controlled design and multi-modal magnetic resonance imaging (Devon, UK; 2015–2016). Training improved working memory performance and increased intrinsic functional connectivity between the bilateral intraparietal sulci. Furthermore, improvements in working memory were associated with greater recruitment of the left middle frontal gyrus on a complex span task. Repeated engagement of fronto-parietal regions during training may increase their activity and functional connectivity over time, affording greater working memory performance. The plausibility of generalizable cognitive benefits from a neurobiological perspective and implications for neurodevelopmental theory are discussed. 相似文献
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Guilherme Giannini Artioli Craig Sale Rebecca Louise Jones 《European Journal of Sport Science》2019,19(1):30-39
AbstractCarnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease. 相似文献
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ABSTRACTThe preservation of artefacts in museum collections is profoundly affected by fluctuations in temperature and, especially, relative humidity (RH). Since the late nineteenth century, many studies have been carried out on the best way to control hygrothermal conditions. In old buildings located in maritime temperate climate zones (such as Portugal) with strong thermal inertia, and which have low ventilation rate (relative to the volume and number of visitors), daily and seasonal hygroscopic inertia may help to assure the maintenance of RH stabilization conditions. The use of expensive active systems may be minimized through the passive behaviour of internal finishing building materials. This work presents the results of an experimental laboratory study conducted in a flow chamber to demonstrate the enormous potential of hygroscopic materials in stabilizing interior relative humidity. Based in these results and in-situ monitoring in a museum housed in a building, located in Porto, with a typical construction of the 1950s (granite masonry and reinforced concrete slabs), a numerical analysis was done to quantify the influence of hygroscopic materials in stabilizing the interior relative humidity. 相似文献
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V. J. Hinton D. C. De Vivo R. Fee E. Goldstein Y. Stern 《Learning disabilities research & practice》2004,19(3):146-154
Duchenne Muscular Dystrophy (DMD) is a neurogenetic developmental disorder that presents with progressive muscular weakness. It is caused by a mutation in a gene that results in the absence of specific products that normally localize to muscle cells and the central nervous system (CNS). The majority of affected individuals have IQs within the normal range, generally with lower verbal than performance IQ scores. Prior work has demonstrated selective deficits on tests of verbal span and immediate memory. For the current study, 26 boys with DMD (and normal intellectual function) and their unaffected siblings were evaluated. Paired comparisons demonstrated that the children with DMD had significantly poorer academic achievement scores than their siblings, even though their vocabulary levels and home and educational environments were comparable. Children with DMD also had more behavioral concerns, physical disabilities, and poorer verbal memory spans. Linear regression indicated that behavioral concerns, executive function, and physical disability did not contribute substantially to academic performance, whereas performance on verbal span did. DMD presents with a selective developmental aberration in verbal span that has wide‐ranging consequences on learning skills. 相似文献
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