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1.
Kavita Shalia Sudha Savant Vijaya A. Haldankar Tulip Nandu Poonam Pawar Siddhi Divekar V. K. Shah Purvi Bhatt 《Indian journal of clinical biochemistry : IJCB》2012,27(1):74-82
To analyse the association of high sensitivity C-reactive (hsCRP) protein levels and −717A/G single nucleotide polymorphism
of CRP with acute myocardial infarction (AMI) in the Indian population. Study population included 100 MI cases wherein 32
patients had experienced previous MI (MI-Group-1), 68 MI cases were recruited at presentation (MI-Group-2) and equal number
of age and gender matched healthy individuals. hsCRP levels were determined by ELISA and genotyping of −717A/G was carried
out by polymerase chain reaction-based restriction digestion method. The −717A/G genotypes did not influence hsCRP level and
their distribution did not differ between groups. However, in the present study hsCRP demonstrated significant correlation
with BMI in controls of both the genders and with triglycerides in females of AMI at presentation who otherwise are with low
risk profile. Identifying traditional risk factors associated with inflammation may help in controlling the acute event. 相似文献
2.
Jeannie L. Pridmore Randy V. Bradley Nikhil Mehta 《Decision Sciences Journal of Innovative Education》2010,8(2):289-311
In introductory information technology (IT) courses, communicating technical concepts so that they can be comprehended by all students, technical and nontechnical, has been a concern. Another challenge in such courses is to teach the real‐world applicability of technical concepts. In this conceptual article, we focus on a relatively unexplored issue in IT education—which instructional method is more effective in improving the learning outcomes of all students taking introductory IT courses. In doing so, we consider two instructional methods, lecture and multimedia case studies, and argue that either of these instructional methods, adopted singly, will be perceived by students as less effective in accomplishing learning outcomes than adopting a combination of the two instructional methods. Our arguments both augment existing knowledge about the differential influence of lecture and multimedia case studies on students’ learning outcomes and questions the wisdom of adopting either of these methods singly in introductory IT courses. We derive insights from the literature and anecdotal evidence, presented as four propositions, which illustrate the relationship between the two instructional methods and the specific learning outcomes students perceive they affect. 相似文献
3.
Drug metabolism involves the enzymatic conversion of therapeutically important chemical species to a new molecule inside the human body. The process may result in pharmacologically active, inactive, or toxic metabolite. Drug metabolic process involves two phases, the occurrence of which may vary from compound to compound. In this article, we discuss the basics of drug metabolism, the process, metabolising organs and enzymes (especially CYP450) involved, chemistry behind metabolic reactions, importance, and consequences with several interesting and significant examples to epitomize the same. We also cover the factors influencing the process of drug metabolism, structure-toxicity relationship, enzyme induction and inhibition. 相似文献
4.
Researchers have emphasized on the need for advances in knowledge management (KM) research to better understand how organizations accrue benefits from their knowledge resources. Thus, an integrated approach, rooted in the theoretical streams of knowledge-based view, KM and institutional theory, is proposed to explain how a successful KM program creates value. The approach discusses four organizational capabilities that firms need to develop simultaneously to create KM-enabled value, and identifies possible organizational actions to develop these capabilities. Various feedback and feed-forward processes, originating inside as well as outside the firm, integrate these capabilities into a KM-enabled value creation cycle (VCC). Key propositions were developed, and were examined with the help of three case studies. 相似文献
5.
Rachel Lord Keith George John Somauroo Nikhil Jain Kristin Reese Martin D. Hoffman 《European Journal of Sport Science》2016,16(8):1014-1022
Background: Prolonged strenuous exercise has a profound effect on cardiac function. The right heart may be more susceptible to this imposition; yet, right-sided chest leads have not been utilised in this setting. Methods: Thirty highly trained athletes at the 2014 Western States 100-mile Endurance Run from Squaw Valley to Auburn, California (body mass 68?±?12?kg, age 45?±?10?years, 57?±?15?miles per week) were recruited for the study. Pre- and post-race, a right-sided 12-lead ECG was obtained and data were extracted for P, R and S waves, J point, ST segment and T wave amplitude. Data were compared using Students T-test and statistical significance set as P?Results: There was a significant increase in P wave amplitude (29%) and QTc interval (4%) pre- to post-race from standard 12-lead ECG. From the right-sided12-lead ECG, a 23% (P?=?.01) and 38% (P?=?.03) increase in J point amplitude in V1R and V2R and a 22% (P?=?.05) increase in ST segment integral in V2R and V3R were evident. T wave inversion was evident in leads V2R–V6R in 50–90% of athletes, respectively. Close examination revealed marked heterogeneity in individual ECGs. Conclusions: Completion of a 100-mile ultra-marathon resulted in significant changes in the right-sided ECG alongside more marked responses in specific individuals. P wave, ST segment and T wave changes post-race are indicative of acute exercise-induced right heart electrical adaptation. 相似文献
6.
Ranjana Singh Rajesh K. Singh Anil K. Tripathi Nikhil Gupta Ajai Kumar Anil K. Singh Abbas A. Mahdi Rajendra Prasad Raj K. Singh 《Indian journal of clinical biochemistry : IJCB》2004,19(1):14-20
The circadian periodicity of plasma lipid peroxide levels and activities of superoxide dismutase (SOD), catalase (CAT) and
glutathione peroxidase (GPx) were studied in 50 clinically, bacteriologically and radiologically proven fresh cases of pulmonary
tuberculosis (age: 21–45 years) and 60 age-matched healthy volunteers with diurnal activity from 06∶00 to about 22∶00 and
nocturnal rest. A marked circadian variation in plasma lipid peroxide level was recorded in healthy subjects and pulmonary
tuberculosis patients with significant amplitude and acrophase around 16∶21 and 17∶12 respectively. The acrophase tended to
be delayed in tuberculosis patients. Furthermore, a statistically significant circadian rhythm was found in SOD, CAT and GPx
activities in normal volunteers and pulmonary tuberculopsis patients. SOD and CAT enzyme activity was noted to be maximum
at 06∶00 and minimum at 00∶00 in tuberculosis patients. The circadian acrophase for GPx activity was recorded at 16∶15 in
normals and around 22∶45 in patients. Moreover, the activity was found to be decreased at all sampling hours during 24-hours
sleep-awake period in patients in comparison to healthy counterparts. The MESOR and circadian amplitude also decreased markedly.
The decreased activity of measured antioxidant enzymes in pulmonary tuberculosis patients could probably be associated with
oxidative stress and/or decreased anti-oxidant defensive mechanism in such patients. 相似文献
7.
Over the series of articles on circadian rhythms, we saw that living organisms exhibit daily rhythms in multiple behaviours and physiological processes. Although some rhythms may be passive responses to 24 h environmental cycles, many are regulated by endogenous-rhythmgenerating machinery called circadian clocks. We have introduced the concept of circadian clocks, their organization and the underlying molecular mechanisms. In this article, we will dwell upon one of the most fundamental questions pertaining to circadian clocks, ‘Why do we have them?’. The aim of this article is not to provide answers, but to discuss the efforts and strategies used to address this question and critically evaluate explanations proposed till date. 相似文献
8.
Singh B Goswami B Gupta N Bajaj AD Mallika V 《Indian journal of clinical biochemistry : IJCB》2011,26(1):41-45
Preterm delivery is a major contributor for neonatal mortality. Intensive research is underway to establish a reliable biomarker
that can ascertain the risk of preterm delivery in pregnant women. The aim of our study was to evaluate the role of various
biochemical parameters as potential biomarker for risk assessment for preterm labor. Forty women presenting with preterm labor
and 40 women who delivered at term were included in the study. Parameters that were evaluated include corticotrophin (ACTH),
prolactin, thyroid stimulating hormone (TSH), ferritin and Alkaline Phosphatase (ALP). Serum ACTH, ferritin, ALP and Ferritin/Iron
ratio were significantly higher in the subjects who delivered prematurely as compared to the controls. Comparison of sensitivity,
specificity, likelihood ratio, positive and negative predictive values for different cut offs for ACTH, ferritin, ALP and
ferritin/iron ratio was carried out. Ferritin emerged as the best marker with area under curve of 0.96 as compared to 0.88
for ACTH, 0.825 for ALP and 0.735 for ferritin/iron ratio. Our study establishes the superiority of ferritin as a predictive
biomarker for preterm labor as compared to the rest of the parameters evaluated. 相似文献
9.
Harshini Sriram Twinkle Khanka Shweta Kedia Priyanka Tyagi Sitaram Ghogale Nilesh Deshpande Gaurav Chatterjee Sweta Rajpal Nikhil V Patkar Papagudi G Subramanian Sumeet Gujral Syed Hasan Prashant R Tembhare 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(3)
IntroductionMicroRNAs are small, non-coding RNA molecules that are becoming popular biomarkers in several diseases. However, their low abundance in serum/plasma poses a challenge in exploiting their potential in clinics. Several commercial kits are available for rapid isolation of microRNA from plasma. However, reports guiding the selection of appropriate kits to study downstream assays are scarce. Hence, we compared four commercial kits to evaluate microRNA-extraction from plasma and provided a modified protocol that further improved the superior kit’s performance.Materials and methodsWe compared four kits (miRNeasy Serum/Plasma, miRNeasy Mini Kit from Qiagen; RNA-isolation, and Absolutely-RNA MicroRNA Kit from Agilent technologies) for quality and quantity of microRNA isolated, extraction efficiency, and cost-effectiveness. Bioanalyzer-based Agilent Small RNA kit was used to evaluate quality and quantity of microRNA. Extraction efficiency was evaluated by detection of four endogenous control microRNA using real-time-PCR. Further, we modified the manufacturer’s protocol for miRNeasy Serum/Plasma kit to improve yield.ResultsmiRNeasy Serum/Plasma kit outperformed the other three kits in microRNA-quality (P < 0.005) and yielded maximum microRNA-quantity. Recovery of endogenous control microRNA i.e. hsa-miR-24-3p, hsa-miR-191-5p, hsa-miR-423-5p and hsa-miR-484 was higher as well. Modification with the inclusion of a double elution step enhanced yield of microRNA extracted with miRNeasy Serum/Plasma kit significantly (P < 0.001).ConclusionWe demonstrated that miRNeasy Serum/Plasma kit outperforms other kits and can be reliably used with a limited plasma quantity. We have provided a modified microRNA-extraction protocol with improved microRNA output for downstream analyses. 相似文献
10.
Megan Dutton Janine Gray Danielle Prins Nikhil Divekar Nicholas Tam 《Journal of sports sciences》2020,38(10):1096-1104
ABSTRACT This study aimed to describe stationary overhead throwing biomechanics in South African cricketers, considering playing level, and relative to baseball. Kinematics and ground reaction forces were collected during throwing trials. Inverse dynamics was used to calculate joint kinetics. Inter-subject variability was calculated using the coefficient of variance. A one-dimensional statistical parametric mapping ANOVA was conducted to assess differences between the kinematic waveforms in elite and amateur cricketers (p < 0.05). Fifteen cricketers (elite = 8; amateur = 7) participated in this study. The basic parameters of a cricketer’s throwing action are described. Substantial inter-subject variability was noted for all variables, except lumbopelvic movement. Cricketers presented with 74.9 ± 27.3° glenohumeral external rotation and 94.8 ± 23.7° elbow flexion, at maximum external rotation (MER). Amateur cricketers displayed decreased elbow flexion range of motion between 2-14% of the throwing cycle (F = 9.365;p = 0.01); greater shoulder (121.0vs85.9 N; F = 0.36,p = 0.021) and elbow compression (105.6vs72.8 N;F = 0.007,p = 0.043), and superior shoulder force (203.1vs115.5 N;F = 2.43,p = 0.022) at MER, when compared with elite cricketers. Cricketers display similarities to baseball pitchers when throwing overhead from a stationary position. The “preparatory arc” utilised is different to the wind-up noted for baseball. The forces exerted on the shoulder and elbow, in amateur cricketers specifically, are substantially greater at MER and may indicate the potential risk for injury. 相似文献