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The aims of this study were to examine the changes in plasma concentrations of inflammatory cytokines induced by training and competition in professional cyclists. We report the serum concentrations of interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-a), tumour necrosis factor receptors I and II (TNFR-I and -II) in a prospective, randomized, double-blind trial involving the administration of AM3 (Inmunoferon), an oral booster immunomodulator, or placebo to 16 professional cyclists (n = 8 in each group) for 65 consecutive days. Serum was collected just before treatment began (baseline), at the end of pre-competition training, before the mountain stage of the competition (60 days), 4 h after finishing this stage (62 days), and 18 h after the fifth and last day of competition (65 days). To determine the normal levels of cytokines and soluble TNF receptors, individual samples from 14 moderately trained healthy controls were studied. After 60 days of training, the serum concentrations of IL-6 did not differ significantly from those at the beginning of the study for either group of cyclists (placebo and AM3). A significant rise was seen in IL-6 concentrations in both the AM3 and placebo groups at 62 days, 4 h after finishing the mountain stage. The increase was significantly greater in the placebo group than in the AM3 group. At 65 days of treatment, 18 h after the fifth and last day of competition, IL-6 concentrations were similar to those recorded at the end of the training, but were significantly higher in the placebo group than in the AM3 group. At the end of training, serum TNFR-I concentrations in both groups of cyclists were significantly lower than at baseline. The concentrations of serum TNFR-I and -II both 4 h after finishing the mountain stage and 18 h after the fifth and last day of competition were significantly higher than those recorded after training in both groups. Professional cycling competition is associated with increases in serum IL-6 and TNFR-I and -II concentrations. Inmunoferon treatment reduced significantly the concentrations of IL-6 but not those of TNFR-I and -II. 相似文献
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Urquhart C Thomas R Ovens J Lucking W Villa J 《Health information and libraries journal》2010,27(4):277-285
Background: Various methods of impact assessment for health library services exist, including a toolkit developed for the UK. The Knowledge, Resource and Information service (KRIS) for health promotion, health service commissioning and public health (Bristol area, UK) commissioned an independent team at Aberystwyth University to provide an impact assessment and evaluation of their services and to provide evidence for future planning. Objective: The review aimed to provide an action plan for KRIS through assessing the impact of the current service, extent of satisfaction with existing services and views on desirable improvements. Methods: Existing impact toolkit guidance was used, with an adapted impact questionnaire, which was distributed by the KRIS staff to 244 users (response rate 62.3%) in early 2009. The independent team analysed the questionnaire data and presented the findings. Results: Users valued the service (93% considered that relevant information was obtained). The most frequent impacts on work were advice to patients, clients or carers, and advice to colleagues. Literature searching and current awareness services saved staff time. Many users were seeking health promotion materials. Conclusion: The adapted questionnaire worked well in demonstrating the service impacts achieved by KRIS, as well as indicating desirable improvements in service delivery. 相似文献
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This paper introduces a set of services for the creation of on-line surveys, questionnaires, exams and self-assessment tests within a virtual community system used in e-learning settings. The system, called ＂Online Communities＂, is a dynamic web application used as platform for blended learning activities by the Faculty of Economics of the University of Trento. The functionalities added to the platform are contextualized into virtual communities, where activities take place. This allows us to create, submit and analyze questionnaires within and/or outside the boundaries of a community. Furthermore, the system allows to manage libraries of queries organized by the teacher/administrator of the community according to topics and levels of difficulty, in order to produce tests and generate self-assessment sessions on behalf of students. The addition of a questionnaire/ poll/self-assessment tool to a virtual community system can add a lot of interesting features, mainly using the inheritance mechanism implemented among different hierarchically-connected communities. This paper will present these functionalities and highlight one of these services, precisely the one dedicated to self-assessment. In the system, self-assessment tests have indeed a double nature： （1） They are useful to students for checking their own level of preparation; and （2） They are useful to lecturers as an indicator of the level of preparation reached by the students. In order to encourage the use of the system within the whole educational process, and not to limit the real use of the service to the period of the final exams only, the possibility has been foreseen for each participant to share his/her own test results, comparing them with the other members of the community, and even offering real ＂challenges＂, thus transforming passive and ＂solitary＂ learning into something much more stimulating and ＂social＂. 相似文献
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García-López J Rodríguez-Marroyo JA Juneau CE Peleteiro J Martínez AC Villa JG 《Journal of sports sciences》2008,26(3):277-286
The aims of this study were to measure the aerodynamic drag in professional cyclists, to obtain aerodynamic drag reference values in static and effort positions, to improve the cyclists' aerodynamic drag by modifying their position and cycle equipment, and to evaluate the advantages and disadvantages of these modifications. The study was performed in a wind tunnel with five professional cyclists. Four positions were assessed with a time-trial bike and one position with a standard racing bike. In all positions, aerodynamic drag and kinematic variables were recorded. The drag area for the time-trial bike was 31% higher in the effort than static position, and lower than for the standard racing bike. Changes in the cyclists' position decreased the aerodynamic drag by 14%. The aero-helmet was not favourable for all cyclists. The reliability of aerodynamic drag measures in the wind tunnel was high (r > 0.96, coefficient of variation < 2%). In conclusion, we measured and improved the aerodynamic drag in professional cyclists. Our results were better than those of other researchers who did not assess aerodynamic drag during effort at race pace and who employed different wheels. The efficiency of the aero-helmet, and the validity, reliability, and sensitivity of the wind tunnel and aerodynamic field testing were addressed. 相似文献
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大多数教育工作者都认为问题解决很重要,但是他们对什么是问题解决持有不同观点,在怎样教给学生问题解决的本领上也没有达成一致意见。各种不同观点主要集中于将问题解决视为教育目标、教育方法以及技能训练之间的差异问题上。其一,目标型问题解决不应只限于良构问题解决,而应该延伸到现实问题解决;其二,对初学者来说,方法型问题解决有其明显的局限性,给予这些学习者足够帮助,对于培养他们的问题解决能力具有重要作用;其三,技能型问题解决不应被看作是只在培养专长过程的初期才会出现,而应被视为在系统1模式与系统2模式中平行发展的一个过程。总结以上观点,综合学习设计模式完全可以用来促进此三种类型的问题解决,并其本回答了问题解决最好应该怎样教的问题。 相似文献
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Real‐world phenomena simulation models, which can be used to engage middle‐school students with probability, are described. Links to R instructional material and easy‐to‐use code are provided to facilitate implementation in the classroom. 相似文献
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In this study we compare the distribution of parental educational styles and the scores reported both by parents and students for various family characteristics (acceptance, control, involvement, and expectations) and socio‐demographic factors (socio‐economic status, family structure, number of children, and order of birth of the children) in a group of adolescents with normal achievement (n?=?105) and in a group which present low achievement (n?=?205). Likewise, we examine which variables best predict academic achievement in the two groups and of adolescents. The results indicate differences in the distribution of parental styles in the two groups for the majority of the variables analysed. We also observed a differential pattern in the prediction of academic success. In the group of adolescents with normal academic achievement, socio‐demographic variables better predict achievement; for students with low achievement, family variables play a more important role in predicting achievement. 相似文献
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