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Gian Paolo Caviglia Luca Cabianca Sharmila Fagoonee Fabrizio M. Gili 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2016,26(1):114-120
Introduction
Screening programs for colorectal cancer (CRC) are mainly based on a first-line fecal immunochemical test for hemoglobin (FIT). Fecal M2-type pyruvate kinase (M2-PK) has been evaluated in clinical settings showing promising results for early CRC detection. However, the impact of fecal M2-PK assessment on the performance of first-round CRC screening programs is not known. We investigated whether fecal M2-PK alone or in combination with FIT may improve CRC screening efficacy in the general population.Materials and methods
A total of 1027 asymptomatic subjects (median age 66 [59-74] years; females 504 [49.1%]), identified through the general practitioners’ rosters, were invited for the collection of 2 fecal samples for FIT and M2-PK evaluation. Participants with at least positive one fecal test were referred for colonoscopy. Quality indicators for screening performance were calculated and analyzed using Fisher’s exact test.Results
Overall, 572 subjects underwent both FIT and M2-PK assessment (participation rate 55.7%): 93 participants showed positive results for at least one test (positivity rate 16.3%). Only 10 patients were positive for both tests. Attendance rate to colonoscopy was 86.0% and a total of 65 adenomas and 7 cancers were detected. Combined use of FIT and fecal M2-PK permitted the identification of 18 more neoplasm (25%) without improving colonoscopy workload, as deduced by the comparable number needed to scope (P = 0.402).Conclusion
The addition of M2-PK testing to FIT offers the potential to detect additional neoplasms that either do not bleed or only bleed intermittently without reducing participation rate and without increasing endoscopy workload.Key words: biomarker, colorectal cancer, occult blood, M2-type pyruvate kinase, screening 相似文献3.
CR Duffy D Stewart F Pecoraro PE Riches D Farina A Macaluso 《Journal of sports sciences》2012,30(12):1311-1321
Abstract To investigate the effects of ageing on the neural control strategies governing sprint cycling on a friction-loaded cycle-ergometer, 10 older (aged 70-83yr) and 8 young (aged 19-35yr) healthy women completed seven 6-s all-out cycling trials against varying loads. Root mean square (RMS), median frequency and muscle fibre conduction velocity were determined from the vastus lateralis of the dominant limb during each pedal stroke. Peak power was 43% lower in the older group compared to the younger (p?0.001) and was accompanied by a significantly lower RMS (p?0.05). No differences were observed in the other electromyography (EMG) parameters between the groups (p?>?0.05). ΔRMS from the first to the sixth second during each trial was found to increase significantly with the development of power output in both groups (p?0.05). For the first time during an all-out 6-s cycle trial, it has been demonstrated that older women's lower mechanical power output was accompanied by a significantly lower RMS, which indicates a decline in either the number of active of motor units or a reduced discharge rate. Hence, changes in motor units can be regarded as a contributory factor to the decline of muscle power with advancing age. Overall, though, similar neural strategies are adopted in both younger and older populations. 相似文献
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Although sort has been extensively studied in many research works, it still remains a challenge in particular if we consider the implications of novel processor technologies such as manycores (i.e. GPUs, Cell/BE, multicore, etc.). In this paper, we compare different algorithms for sorting integers on stream multiprocessors and we discuss their viability on large datasets (such as those managed by search engines). In order to fully exploit the potentiality of the underlying architecture, we designed an optimized version of sorting network in the K-model, a novel computational model designed to consider all the important features of many-core architectures. According to K-model, our bitonic sorting network mapping improves the three main aspects of many-core architectures, i.e. the processors exploitation, and the on-chip/off-chip memory bandwidth utilization. Furthermore we are able to attain a space complexity of Θ(1). We experimentally compare our solution with state-of-the-art ones (namely, Quicksort and Radixsort) on GPUs. We also compute the complexity in the K-model for such algorithms. The conducted evaluation highlight that our bitonic sorting network is faster than Quicksort and slightly slower than radix, yet being an in-place solution it consumes less memory than both algorithms. 相似文献
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Luisa Berto Tommaso Favaretto Anna Saetta Fabrizio Antonelli Lorenzo Lazzarini 《Journal of Cultural Heritage》2012,13(1):7-21
The seismic assessment of art objects requires a multidisciplinary approach and the definition of a specific methodology for evaluating the level of safety and the possible interventions necessary for seismic risk prevention, finding a compromise between safety and conservation. This paper describes a first step in this direction, in which the different aspects of the procedure, from knowledge path of the art object to the structural analysis, were studied in the six Michelangelo's statues located in the “Galleria dei Prigioni” (Slaves’ Gallery) at the Accademia Gallery of Florence. We showed that the general principles and criteria expressed in the “Italian Guidelines for evaluation and mitigation of seismic-risk to cultural heritage”, which are specifically devoted to masonry constructions, could be profitably extended to other artworks, like statues, starting from historical research, geometrical survey and material characterization, up to the developing of specific methods of analysis. This research could be the base for future studies to be performed concerning the prevention of seismic damage of art objects, including both bare minimum interventions and specific devices, such as isolation systems. 相似文献
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Alberta Silvestri Serena Tonietto Francesco D’Acapito Gianmario Molin 《Journal of Cultural Heritage》2012,13(2):137-144
This work reports mainly the results of an X-ray Absorption Spectroscopy (XAS) study carried out on coloured glass tesserae from the palaeo-Christian mosaic which decorated the votive chapel of St. Prosdocimus (Padova) until its replacement with the current frescoes of Renaissance age, and which is one of the only two known mosaics in the Veneto region (Italy). The study aims at clarifying how the different local structure, oxidation state and quantity of copper influenced colour. Analysis of high-resolution Cu-K edge X-ray Absorption Near Edge Structure (XANES) and Extended X-ray Absorption Fine Structure (EXAFS) spectra showed that copper is present as cuprite (Cu2O) in orange samples and as metallic copper in red and brown ones. These phases are responsible for both the colour and opacity of the samples. In addition, Cu1+ ions linked to the oxygen atoms of the glass framework were identified in ratios of about 60% and 30% of total copper in orange and red/brown samples, respectively. In blue and green samples, copper is dispersed in the glass matrix as a mixture of Cu1+ and Cu2+ ions, and no crystalline phases are visible. In this context, the Cu1+ and Cu2+ contents in glass were also quantified thanks to suitable standards, demonstrating that, when Cu2+ is the main chromophorous ion, colour intensity is directly correlated to its content in the glass. In particular, in green and blue samples, coloured by copper, Cu2+ content varies from 26% to 56% of total copper, and the higher contents of Cu2+ are shown by more intensely coloured samples. It should be stressed here that the green colour of the analysed tesserae is given by the physical interaction of blue colour, due to Cu2+ ions, and yellow colour, due to Pb antimonates used as opacifiers. 相似文献
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Anne-Sophie Hayek Claudia Toma Sofia Guidotti Dominique Oberlé Fabrizio Butera 《European Journal of Psychology of Education - EJPE》2017,32(1):97-112
At school, pupils often cooperate on common projects and must coordinate their different individual actions. However, grades are pervasively used even in cooperative situations, which make the pupils’ differences in achievement and their relative rank salient and may reduce their inclination to work constructively with others. Thus, we hypothesized that grades would elicit disruptive interactions and reduce performance in a cooperative cognitive-motor task necessitating inter-individual coordination of members. In a study with 5th graders, grades (vs. a neutral concept) were primed at the onset of a cooperative group interaction. Results showed that, although pupils were set to work cooperatively, priming grades (vs. neutral concepts) harmed inter-individual coordination by eliciting more negative dominant behaviours among pupils during interactions, which decreased group performance. 相似文献
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Previous studies with university students have shown that resource interdependence during cooperative dyadic work on texts
produces two different dynamics in student interaction and learning. Working on complementary information produces positive
interactions, but a good quality of information transmission is needed to foster student learning. Working on identical information
produces a confrontation of viewpoints but also encourages a threatening social comparison of competence, which can be detrimental
for learning. The aim of present study is to test the moderating role of a partner’s competence in two peer-learning methods
by manipulating a partner’s competence through a confederate. Results indicate that a partner’s competence is beneficial when
students work on complementary information while it is detrimental when students work on identical information. 相似文献
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Luca Merigo Manuel Beschi Fabrizio Padula Antonio Visioli 《Journal of The Franklin Institute》2018,355(2):774-802
In this paper we propose a new event generator, which has strong noise-filtering capabilities, to be used in event-based control systems with a PIDPlus controller. An approximate frequency analysis is performed in order to characterize the event generator system and tuning guidelines are provided for its design parameter. Simulation and experimental results obtained with a laboratory setup demonstrate the effectiveness of the methodology in providing a satisfactory performance related to set-point and load disturbance step responses with a total variation that is significantly reduced with respect to the standard cases. 相似文献
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Business cycles modify firms’ incentives to innovate and the direction of innovation. By introducing a new measure of patent unconventionality this paper explores the impact of the business cycle on firms’ technological search strategies. We find that during upturns firms generate inventions characterized by a higher level of technological unconventionality. We also find that financially resilient and diversified firms produce more unconventional patents. While patent unconventionality is associated with technological impact and market value, firms extract more value by investing in unconventional inventions in downturns. 相似文献