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2013年4月26日至5月8日,江苏省江阴市高级中学师生一行共22人前往德国,访问罗伯特·科赫学校。在德期间,我们与德国师生进行了广泛的交流,见闻不少,感触颇多。罗伯特·科赫学校建立于1970年,位于巴伐利亚州(Bavaria)距州府慕尼黑(Munich)100多公里的德根道尔夫市(Deggendorf),美丽的多瑙河在它旁边缓缓流淌。罗伯特·科赫学校是以当地1905年获得诺贝尔医学奖的罗伯特·科赫(Robert 相似文献
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INTRODUCTIONFibroblastgrowthfactor (FGF)isanangio genicandmitogenicpolypeptidethatcanpromotecellproliferationanddifferentiationinawideva rietyofcelltypes (Goldfarb ,1 990 ;Basilicoetal.,1 992 ) .TheFGFfamilyhasmanymemberswithsimilaraminoacidsequenceandbiologicala… 相似文献
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Human acidic and basic fibroblast growth factors (aFGF and bFGF) are classic and well characterized members of the heparin-binding
growth factor family. Heparin is generally thought to play an extremely important role in regulating aFGF and bFGF bioactivities
through its strong binding with them. In order to unravel the mechanism of the interactions between heparin and FGFs, and
evaluate the importance of heparin sulfate groups' binding with FGFs, surface plasmon resonance analyses were performed using
IAsys Cuvettes System. Heparin and its regioselectively desulfated derivatives were immobilized on the cuvettes. aFGF and
bFGF solutions with different concentrations were pipetted into the cuvettes and the progress of the interaction was monitored
in real-time by Windows-based software, yielding kinetic and equilibrium constants for these interactions. In addition, in
order to reduce the delicate difference among the cuvettes, inhibition analyses of mixtures of FGFs and immobilized native
heparin by modified heparins were also done. The data from these two methods were similar, indicating that all sulfate groups
at 2-O, 6-O and N- in heparin were required for the binding to aFGF; and that their contribution to the binding was in the
order 2-O, N- and 6-O-sulfate group. In contrast, definite contribution of the 6-O-sulfate group to the binding with bFGF
was most apparent, while the other two sulfate groups appeared to be necessary in the order 2-O and N-sulfate group. These
methods established here can be used for analysing the effect of sulfate groups in heparin on the binding with other human
FGF members or other heparin-binding proteins.
The project supported by the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry
of China and Zhejiang Provincial Natural Science Foundation of China (301306) 相似文献
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沈国新 《黄冈师范学院学报》1989,(4)
设给定了初始项 xk 及常数 ak(k=0,1,…,m—1),a_0≠0,则称满足递推关系 x_n+m=(?)的数列为 m 阶线性齐次递推数列.它的通项问题有一个理想的、完整的结果,这是大家所熟知的.然而,它的各种拓广形式的通项求法是一个十分复杂的问题.这里,我们就常见于中数杂志及复习资料中的一种拓广形式——对于给定了初始项 xk 及常数 ak, 相似文献
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沈国新 《中学数学教学参考》1999,(6)
一、关于探索性问题的概念数学题一般分为稳定情境题和问题情境题.当然随着知识扩充、发展、延伸,问题情境题和稳定情境题可相互转化.例如解方程2x2-3=5对于低年级学生来说是问题情境题,而对于高年级学生来说是一个稳定情境题.解题就是将问题情境题转化为稳定... 相似文献
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