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Wojciech Szczęsny Magdalena Kuligowska-Prusińska Stanisław Dąbrowiecki Jakub Szmytkowski Adrian Reśliński Maciej Słupski 《Journal of Zhejiang University. Science. B》2018,19(1):65-70
Purpose
Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls.Materials and methods
The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA).Results
A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group.Conclusions
The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.2.
Danuta Ro?? Przemys?aw Adamczyk Joanna Boinska Robert Szafkowski Irena Ponikowska Katarzyna Stankowska Barbara Góralczyk Barbara Ruszkowska-Ciastek 《Journal of Zhejiang University. Science. B》2015,16(5):404-411
Objective
The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy.Methods
The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m2. Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m2.Results
In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced.Conclusion
The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.3.
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Sliding mode control of manipulators using first-order equations of motion with diagonal mass matrix
Przemys?aw Herman 《Journal of The Franklin Institute》2005,342(4):353-363
This paper presents a proposition of a sliding mode controller for a rigid manipulator expressed in terms of the generalized velocity components (GVC) vector. Introduction of GVC (Trans. ASME J. Appl. Mech. 62 (1995) 216) together with generalized positions leads to two first-order decoupled equations of motion instead of a single second-order equation. It is shown that the new controller, stable in the sense of Lyapunov, has different properties and can, according to Slotine and Li (Int. J. Robotics Res. 6 (1987) 49), give better performance than the classical sliding mode controller. Both control algorithms were tested on a 3 d.o.f., 3-D Yasukawa-like robot. 相似文献
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AbstractThe world of radical football fans across Europe is dominated by anti-system groups. While their sympathies in the west of the continent are mostly leftist, the ultras in the east tend to display right-wing attitudes. Poland makes a particularly interesting case in point, as the most intensive and emotional ideological criticism of the processes of ‘transformation’ and ‘modernisation’ is to be observed at the stadiums. As a result of historical developments, opposition against the system in the country can only be expressed using Catholic–patriotic symbolism, which in the case of collective actions of radical football supporters has produced sociocultural and aesthetic effects not to be found anywhere else in Europe. 相似文献
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In this paper we consider the problem of designing an efficient supply strategy for logistic systems with perishable goods. In the analyzed systems, the stock at a distribution center is used to fulfill an unknown, time-varying market demand. The stock deteriorates exponentially, and is replenished with delay from a remote supply source. The objective is to specify a supply strategy such that high level of demand satisfaction is obtained despite unknown pattern of demand variations. As opposed to the previous approaches based mainly on heuristics and static optimization, we apply formal design methodology of sliding-mode control and discrete-time dynamical optimization. We show that the designed controller ensures full demand satisfaction irrespective of the value of delay and the demand uncertainty. Moreover, with the application of appropriate reaching law, the controller is demonstrated to conform to the supplier capacity limitations, and it outperforms the classical order-up-to policy in terms of higher service level, smaller holding costs, and smaller order-to-demand variance ratio. 相似文献