排序方式： 共有17条查询结果，搜索用时 15 毫秒
1.
Emad F. Eskander Ahmed A. Abd-Rabou Shaymaa M. M. Yahya Ashraf El Sherbini Mervat S. Mohamed Olfat G. Shaker 《Indian journal of clinical biochemistry : IJCB》2014,29(1):3-7
Viral infection with hepatitis C virus (HCV) has a high propensity in becoming chronic and it is the major cause of hepatocellular carcinoma (HCC) worldwide. This review was basically established to illustrate the putative role of the P53 gene Arg72Pro polymorphism on various cancer models and viral infections, focusing on HCV and HCC incidences. Authors studied the 72 G/C single base substitution of P53 gene at codon 72 using various polymorphic techniques. Intriguingly, authors investigated that the P53 codon 72 plays a crucial role as risk factor in several cancer models. Others found that there is no association between codon 72 genotypes and HCV disease severity or liver cancer. Moreover, the lack of a significant relationship between this polymorphism and risk of HCC shows that it does not predispose towards hepatocarcinogenesis and the frequent loss of the proline allele in HCV-associated carcinogenesis of the liver plays some critical role in hepatocarcinogenesis. Amazingly, there is a significant correlation between male homozygotes for P53 72Pro with HCV type 1b infection. However, there was no significant difference between the P53 polymorphism and HCV genotypes 2a and 2b. It was concluded that the P53 gene polymorphism at codon 72 has been investigated as potential risk factor in several cancer models and HCV infections. 相似文献
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Shaymaa M. M. Yahya Shadia A. Fathy Zakaria A. El-Khayat Safinaz E. El-Toukhy Ahmed R. Hamed Marwa G. A. Hegazy Heba K. Nabih 《Indian journal of clinical biochemistry : IJCB》2018,33(1):21-30
Hepatocellular carcinoma (HCC) is a hypervascular primary liver cancer characterized by rapid progression, besides, resistance to traditional chemotherapeutic agents. It has been shown that microRNAs play critical roles in regulation of tumor cell sensitivity to drugs through modulating the expression of genes involved in drug transport. The present study investigated whether restoration of miR-122 in HCC cells could alter the cell cycle distribution and the expression of multidrug resistance (MDR)-related genes (ABCB1, ABCC1, ABCG2 and ABCF2). After overexpression of miR-122 in HepG2 cells treated or untreated with doxorubicin doses, total RNAs and protein extracts were isolated for application of QRT-PCR and western blotting techniques. Moreover, cell cycle distribution was monitored by flow cytometry. Our results revealed that, the over expression of miR-122 in HepG2 cells treated or untreated with doxorubicin could modulate the sensitivity of cells to chemotherapeutic drug through downregulation of MDR-related genes, ABCB1 and ABCF2. Interpretation of cell cycle distribution revealed that, the anti-proliferative effect of miR-122 is associated with the accumulation of cells in G0/G1 phase. Moreover, treatment with miR-122 and doxorubicin resulted in high percentage of HCC cells in G0/G1 phase. Taken together, our findings revealed that, overexpression of miR-122 inhibited HCC cell growth by inducing cell cycle arrest and this arrest is associated with down-regulation of MDR-related genes. 相似文献
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This article explores immigrant mothers’ experiences and perspectives on early learning to identify the underlying principles of parents’ learning theories and their concerns about pedagogic practices at school. It employs data from interviews with nineteen immigrant mothers that reveal a discord between learning beliefs and practices at home and school. The paper argues that mothers’ cultural capital may shape their perspectives on learning, which may subsequently influence their children’s cultural capital and interests. Supporting children’s learning at school requires examining home learning beliefs so that teachers can establish a two-way exchange of knowledge, ideas and perspectives with common objectives of respecting differences and exploring possible reconciliation of differences. This paper urges educators to bridge home and school through engaging in dialogue with parents so that parents’ cultural capital and their understanding about play-based learning work to their children’s advantage. 相似文献
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The complexity of modern chemical and petrochemical plants is becoming increasingly problematic in the recent years. At the same time, the demands to ensure safety and reliability of process operations rise. Early detection of abnormal event in complex real systems decrease maintenance cost and lead to guarantee the safety of human operators and environment. In the present work, a fault detection (FD) method which exploits the advantages of black-box modeling and statistical measure for fault detection in real chemical process as a distillation column is proposed. This technique is developed by applying the Nonlinear Auto-Regressive Moving Average with eXogenous input (NARMAX) model and Bhattacharyya distance (BD). In order to determine the NARMAX model, a real data set recorded during normal operations is used. Then, the BD is used to quantify on-line the dissimilarity between the current and reference probability distributions of the residual obtained from the NARMAX model for fault detection purposes. The ability of the proposed FD approach is demonstrated using real fault of separation unit. The obtained results indicate that the developed technique produces favorable performance compared to the conventional Cumulative Sum (CUSUM) test. 相似文献
5.
Dusdal Jennifer Powell Justin J. W. Baker David P. Fu Yuan Chih Shamekhi Yahya Stock Manfred 《Minerva》2020,58(3):319-342
The world’s third largest producer of scientific research, Germany, is the origin of the research university and the independent, extra-university research institute. Its dual-pillar research policy differentiates these organizational forms functionally: universities specialize in advanced research-based teaching; institutes specialize intensely on research. Over the past decades this policy affected each sector differently: while universities suffered a lingering “legitimation crisis,” institutes enjoyed deepening “favored sponsorship”—financial and reputational advantages. Universities led the nation’s reestablishment of scientific prominence among the highly competitive European and global science systems after WWII. But sectoral analysis of contributions to science, technology, engineering, mathematics, and medical and health journal publications (1950–2010) finds that Germany’s small to medium-sized independent research institutes have made significant, growing contributions, particularly in publishing in higher impact journals proportionally more than their size. Simultaneously—despite dual-pillar policy implications—the university sector continues to be absolutely and relatively successful; not eclipsed by the institutes. Universities have consistently produced two-thirds of the nation’s publications in the highest quality journals since at least 1980 and have increased publications at a logarithmic rate; higher than the international mean. Indeed, they led Germany into the global mega-science style of production. Contrary to assumed benefits of functional differentiation, our results indicate that relative to their size, each sector has produced approximately similar publication records. While institutes have succeeded, the larger university sector, despite much less funding growth, has remained fundamental to German science production. Considering these findings, we discuss the future utility of the dual-pillar policy.
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The aim of this research is to describe and investigate a sample of school gifted students' intrinsic and extrinsic motivations, and the role of their parents in fostering motivational achievements in Jordan. In the study, 122 gifted students were selected to complete a questionnaire (adapted from Pelletier, Fortier and Vallerand et al.) investigating the mentioned constructs. Results showed that students were highly intrinsically and extrinsically motivated. The results also showed significant correlation between intrinsic and extrinsic motivations and perceived competence and parental support scales except for parental control. Other interesting findings were also found regarding the aforementioned constructs. The results further reveal some significant differences in control, achievement goal, amotivation and competence support between genders and education of parents. The possible implications of and recommendations from these findings will be discussed. 相似文献
8.
Chiong Ing Tiong Yahya Azli Mohammed Rafiq Abdul Kadir Samion Syahrullail 《浙江大学学报(A卷英文版)》2012,13(8):633-640
The effects of the mechanical factors with applied loads on the tribological performance of refined, bleached and deodorised (RBD) palm stearin (PS) were studied using a four-ball tribotester. All the RBD PS results were simultaneously compared with the additive-free paraffinic mineral oil (PMO). The experiments were carried out using different loads with a constant speed in order to gain a better understanding of the mechanical processes that occurred during the experiment. For each experiment, the temperature was increased to 75 °C and was run for 1 h. In a mechanical system, lubricant plays an important role in reducing wear and friction. PS exists as a semi-solid at room temperature after the fractionation process from oil palm. Due to the increasing rate of pollution to the environment, vegetable oil was chosen as the test lubricant with regard to its biodegradability. Other advantages of vegetable oil are that it is more easily harvestable and non-toxic compared to petroleum-based oil, which made it a suitable candidate. From the experiment, RBD PS is found to have a better friction constraint reduction compared with additive-free PMO. 相似文献
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Hind Al-Fadda Maha Al- Yahya 《美中教育评论》2010,7(7):100-106
This paper reports on the students＇ experiments of using blogs to encourage themselves to do pre-class reading assignment and reflections after class. The sample in the study included five ESL （English as a Second Language） graduate students in a course of teaching methods, and 90 software engineering students in an undergraduate information technology program. Results indicated that there was a positive attitude towards the use of blogs for pre-class preparation and post-class reflections. However, considering the successful experience, it is important to consider the class size, students＇ educational level, and the type of reading assignment. 相似文献