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1.
In this part we shall outline the challenges one faces while developing time-domain radiofrequency (RF) EPR imaging spectrometer for in vivo studies. Time-domain or FT-EPR is quite a different animal compared to the CW modality. The evolution of FT-EPR instrumentation at the National Cancer Institute, NIH, USA and representative examples of application in cancer research are outlined in this article. 相似文献
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Sankaran Ramanathan 《亚洲交流杂志》2013,23(2):65-91
This article synthesizes the findings of two empirical surveys carried out in 1986 and 1990 in Malaysia. It also presents a brief historical background of the political process in the country, as well as an overview of the Malaysian media. Finally, it touches on the latest general elections in Malaysia, held in 1995, and their implications. 相似文献
3.
Treacy DJ Sankaran SM Gordon-Messer S Saly D Miller R Isaac SR Kosinski-Collins MS 《CBE life sciences education》2011,10(1):18-24
In introductory laboratory courses, many universities are turning from traditional laboratories with predictable outcomes to inquiry-inspired, project-based laboratory curricula. In these labs, students are allowed to design at least some portion of their own experiment and interpret new, undiscovered data. We have redesigned the introductory biology laboratory course at Brandeis University into a semester-long project-based laboratory that emphasizes concepts and contains an element of scientific inquiry. In this laboratory, students perform a site-directed mutagenesis experiment on the gene encoding human γD crystallin, a human eye lens protein implicated in cataracts, and assess the stability of their newly created protein with respect to wild-type crystallin. This laboratory utilizes basic techniques in molecular biology to emphasize the importance of connections between DNA and protein. This project lab has helped engage students in their own learning, has improved students' skills in critical thinking and analysis, and has promoted interest in basic research in biology. 相似文献
4.
EPR (Electron Paramagnetic Resonance) imaging is particularly useful in monitoring hypoxic zones in tumors which are highly resistant to radiation and chemotherapeutic treatment. This first part of the article covers aspects of CW (continuous wave) imaging with details of FT (pulsed Fourier Transform)-EPR imaging covered in Part 2, to be published in the next issue of Resonance. 相似文献
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Siva Sankaran Kris Sankaran Tung Bui 《Decision Sciences Journal of Innovative Education》2023,21(2):68-82
Applying Herzberg's motivation-hygiene theory, we studied the determinants of student satisfaction in using R in a Decision Support Systems course that previously used Excel to teach Data Mining and Business Analytics (DMBA). The course is a degree requirement, and prior programming experience is not a prerequisite. We hypothesized that motivators for student satisfaction with R would include: (i) an intrinsic interest in DMBA, (ii) a perception that R is a better tool than Excel for DMBA, and (iii) a favorable view of R as a facilitator of career advancement. We postulated that the hygiene factor was the compulsory course requirement to learn R, a new and challenging language to students in this study. Data from 120 students, analyzed using Principal Component Analysis (PCA) and Generalized Additive Modeling (GAM), showed that motivators were positively related to satisfaction while hygiene factors were neutral. Students showed willingness to take on a harder challenge in exchange for intrinsic and future career benefits. The model can be useful in curriculum design or career advisement to increase student satisfaction in learning new software skills while meeting market demands. 相似文献
7.
Fluid and electrolyte balance in elite male football (soccer) players training in a cool environment
There are few data in the published literature on sweat loss and drinking behaviour in athletes training in a cool environment. Sweat loss and fluid intake were measured in 17 first-team members of an elite soccer team training for 90 min in a cool (5°C, 81% relative humidity) environment. Sweat loss was assessed from the change in body mass after correction for the volume of fluid consumed. Sweat electrolyte content was measured from absorbent patches applied at four skin sites. Mean (?± s) sweat loss during training was 1.69?±?0.45 l (range 1.06?-?2.65 l). Mean fluid intake during training was 423?±?215 ml (44?-?951 ml). There was no apparent relationship between the amount of sweat lost and the volume of fluid consumed during training (r 2 = 0.013, P = 0.665). Mean sweat sodium concentration was 42.5?±?13.0 mmol?·?l?1 and mean sweat potassium concentration was 4.2?±?1.0 mmol?·?l?1. Total salt (NaCl) loss during training was 4.3?±?1.8 g. The sweat loss data are similar to those recorded in elite players undergoing a similar training session in warm environments, but the volume of fluid ingested is less. 相似文献
8.
Shedid SM Saada HN Eltahawy NA Hammad AS 《Indian journal of clinical biochemistry : IJCB》2018,33(3):314-321
Radiation induced brain damage is associated with impairment of mitochondrial functions, variations in the level of neurotransmitters, and oxidative stress. Mitochondrial function is closely linked to the level of neurotransmitters since the precursors are supplied by the Kreb’s cycle intermediates. The objective of this study was to evaluate the influence of pantothenic acid, an essential component in the synthesis of Coenzyme A (CoA), on the activity of the Krebs cycle enzymes, isocitrate dehydrogenase (IDH), α-ketoglutarate dehydrogenase (α-KGDH), and succinate dehydrogenase (SDH); the level of aspartic, glutamic and GABA; the activity of transaminases, and oxidative stress, in the cerebrum of γ-irradiated rats. Pantothenic acid (26 mg/Kg) was orally administered to the rats, 2 h after irradiation and during the following 5 days. Animals were sacrificed the 7th day post-irradiation. The exposure of male albino rats to γ-rays (5 Gy) has triggered oxidative stress notified by a significant elevation in the level of malondialdehyde (MDA), an end product of lipid peroxidation, associated to a significant decrease in the content of phospholipids, and the antioxidant compound glutathione (GSH). The activity of IDH, α-KGDH, and SDH, has significantly decreased, while the level of aspartic, glutamic and GABA has significantly increased. In parallel to these changes, the activity of alanine and aspartate transaminase has significantly increased, compared to their values in the control rats. Pantothenic acid treatment, has significantly attenuated oxidative stress; enhanced the activity of IDH, α-KGDH, and SDH; minimized the increase in the level of amino acids and the activity of transaminases, compared to their values in the cerebrum of irradiated rats. In conclusion, pantothenic acid could improve the level of neurotransmitters amino acids, which depends on the enzymatic activities of Krebs cycle and linked to oxidative stress. 相似文献
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Praxedes SM de la Rosa 《Asia Pacific Education Review》2005,6(2):170-178
Excellence in teaching has always been a demanding and absorbing concern in institutions of higher learning. Earlier studies,
which are numerous, have often dealt with the measurement of teacher qualities but have largely failed to explain the phenomenon
of excellence in practice. This study focused on the outstanding professional teachers’ candid revelations of their subjective
experiences of becoming and being excellent in their craft. Findings of the study indicated that love is the touchstone of
excellence in teaching: that is, loving the students, loving knowledge and loving the teaching process. 相似文献
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In recent years, HIV-positive athletes hove increasingly made the headlines. leading to questions and concerns regarding HIV transmission through sport. Based on limited understanding and irrational fear. athletes have been excluded from sport competitions or encouraged to retire prematurely. In other cases. they have been subjected to random, mandatory HIV testing prior to sport competition. Because HIV/AIDS is a medical and social problem, information from health-related sources is included in this analysis, including the modes of HIV transmission. This analysis focuses on further issues related to rights, obligations, risks, privacy, and policy. The growing dilemma for the sport professionals to weigh an athlete's right to privacy against their own duty to warn in the decision-making process is examined, with a discussion on mandatory HIV testing for athletes. Guidelines based on principles of medical ethics are offered to aid sport practitioners in providing all athletes with the best possible service. 相似文献