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Since Makita's report (1968), it has been believed that reading disabilities in Japan are extremely rare. However, this argument does not correspond with teachers’observations in elementary schools in Japan. This study tried to re-examine the incidence and characteristics of reading disabilities in Japan. Standardized reading ability and intelligence tests were conducted for 5th grade elementary school children of various districts. It was found that 18.7% of children have one year delay, and 10.9% of children have two or more years delay. This shows that Makita's claim of rarity of incidence of reading disabilities in Japan is incorrect. 相似文献
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Jang K Xu Y Tanaka Y Sato K Mawatari K Konno T Ishihara K Kitamori T 《Biomicrofluidics》2010,4(3):32208
Recently, interest in single cell analysis has increased because of its potential for improving our understanding of cellular processes. Single cell operation and attachment is indispensable to realize this task. In this paper, we employed a simple and direct method for single-cell attachment and culture in a closed microchannel. The microchannel surface was modified by applying a nonbiofouling polymer, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, and a nitrobenzyl photocleavable linker. Using ultraviolet (UV) light irradiation, the MPC polymer was selectively removed by a photochemical reaction that adjusted the cell adherence inside the microchannel. To obtain the desired single endothelial cell patterning in the microchannel, cell-adhesive regions were controlled by use of round photomasks with diameters of 10, 20, 30, or 50 μm. Single-cell adherence patterns were formed after 12 h of incubation, only when 20 and 30 μm photomasks were used, and the proportions of adherent and nonadherent cells among the entire UV-illuminated areas were 21.3%±0.3% and 7.9%±0.3%, respectively. The frequency of single-cell adherence in the case of the 20 μm photomask was 2.7 times greater than that in the case of the 30 μm photomask. We found that the 20 μm photomask was optimal for the formation of single-cell adherence patterns in the microchannel. This technique can be a powerful tool for analyzing environmental factors like cell-surface and cell-extracellular matrix contact. 相似文献
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A prediction model of foreign language reading proficiency based on reading time and text complexity
In textbooks, foreign （second） language reading proficiency is often evaluated through comprehension questions. In case, authentic texts are used as reading material, such questions should be prepared by teachers. However, preparing appropriate questions may be a very demanding task for teachers. This paper introduces a method for automatically evaluating proficiency, wherein comprehension questions are not required. This method assesses a learner＇s reading proficiency on the basis of the linguistic features of the text and the learner＇s reading time. A reading model following this method predicted reading proficiency with an ER （error rate） of 18.2%. This ER is lower than those of models proposed in previous studies. Furthermore, the ER of the authors＇ reading model for various learner groups classified by their RS （reading speeds） was examined. The result of this examination showed that the error rate was the lowest for the group of learners with fast RS. 相似文献
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Immunoassay is one of the important applications of microfluidic chips and many methodologies were reported for decreasing sample∕reagent volume, shortening assay time, and so on. Micro-enzyme-linked immunosorbent assay (micro-ELISA) is our method that utilizes packed microbeads in the microfluidic channel and the immunoreactions are induced on the beads surface. Due to the large surface-to-volume ratio and small analytical volume, excellent performances have been verified in assay time and sample∕reagent volume. In order to realize the micro-ELISA, one of the important processes is the immobilization of antibody on the beads surface. Previously, the immobilization process was performed in a macroscale tube by physisorption of antibody, and long time (2 h) and large amount of antibody (or high concentration) were required for the immobilization. In addition, the processes including the reaction and washing were laborious, and changing the analyte was not easy. In this research, we integrated the immobilization process into a microfluidic chip by applying the avidin-biotin surface chemistry. The integration enabled very fast (1 min) immobilization with very small amount of precious antibody consumption (100 ng) for one assay. Because the laborious immobilization process can be automatically performed on the microfluidic chip, ELISA method became very easy. On-demand immunoassay was also possible just by changing the antibodies without using large amount of precious antibodies. Finally, the analytical performance was investigated by measuring C-reactive protein and good performance (limit of detection <20 ng∕ml) was verified. 相似文献
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Kihoon Jang Yo Tanaka Jun Wakabayashi Reina Ishii Kae Sato Kazuma Mawatari Mats Nilsson Takehiko Kitamori 《Biomicrofluidics》2012,6(4)
Demand for analysis of rare cells such as circulating tumor cells in blood at the single molecule level has recently grown. For this purpose, several cell separation methods based on antibody-coated micropillars have been developed (e.g., Nagrath et al., Nature 450, 1235–1239 (2007)). However, it is difficult to ensure capture of targeted cells by these methods because capture depends on the probability of cell-micropillar collisions. We developed a new structure that actively exploits cellular flexibility for more efficient capture of a small number of cells in a target area. The depth of the sandwiching channel was slightly smaller than the diameter of the cells to ensure contact with the channel wall. For cell selection, we used anti-epithelial cell adhesion molecule antibodies, which specifically bind epithelial cells. First, we demonstrated cell capture with human promyelocytic leukemia (HL-60) cells, which are relatively homogeneous in size; in situ single molecule analysis was verified by our rolling circle amplification (RCA) method. Then, we used breast cancer cells (SK-BR-3) in blood, and demonstrated selective capture and cancer marker (HER2) detection by RCA. Cell capture by antibody-coated microchannels was greater than with negative control cells (RPMI-1788 lymphocytes) and non-coated microchannels. This system can be used to analyze small numbers of target cells in large quantities of mixed samples. 相似文献
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Takayoshi Yoshioka Hitoshi Nishizawa Takehiko Tsukamoto 《Community College Journal of Research & Practice》2013,37(5-6):373-378
This article describes a method used to provide mathematics students in colleges of engineering in Japan with supplementary exercises to aid in their learning. The impact of this effort is also described. An online support function enables instructional personnel to individualize the exercise for students whose abilities vary widely. Individualizing exercises helps students to understand a mathematical method used to solve a problem and also the mathematical idea or concept upon which the method is based. The program described here consists of activities that supplement those in the regular lesson. They are designed to help those students who failed to meet certain course objectives or to solve the problems given in the lesson. Students using the individualized program are allowed to select the problems from among the problem exercises available based on the course objectives that they have not yet satisfied. The online support function of the learning environment that the authors developed assists teaching personnel in the otherwise time-consuming preparation of individualizing these activities. Students determine how well they did on the objectives in the regular lesson by visting the Web page for the course. Information is provided on the impact of the activities on student performance in a fundamental mathematics course in the authors college. 相似文献
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The within-trial contrast hypothesis (WTC) provides a more parsimonious explanation for the phenomenon that humans and animals prefer outcomes that follow more effortful events to outcomes that follow less effortful events (Zentall, 2013). We conducted two WTC experiments with human adults. In Experiment 1, we manipulated the difficulty of a preceding event by varying the interresponse time and the limited-hold interval during differential reinforcement with a low response rate schedule, to examine the effect of effort on the preference for the subsequent stimuli. In Experiment 2, we attempted to identify the variables that had affected the results of Experiment 1, by manipulating time as the delay of reinforcement. The results showed preferences based on WTC only when participants made a high rate of incorrect responses in the preceding event, which was used as an index of the strength of individual effort. These results extend the findings of previous human WTC studies and suggest that the difficulty of a task could serve as an aversive event that affects the WTC effect. It is possible that an index based on performance in the preceding event would provide useful information for predicting the contrast effect. 相似文献
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Quamrul?HasanEmail author Marcelo?Machado Masatoshi?Tsukamoto Katsuhiro?Umemoto 《知识管理研究与实践》2006,4(2):162-169
In the last decade, there has been increasing pressure on academic laboratories to produce practical results. The last 10 years also have seen a growing interest in knowledge management, a management discipline believed to enhance organizations’ innovative capability by the sharing and creation of knowledge. While most knowledge management cases refer to the business setting, we believe that the introduction of these practices can also enhance knowledge creation and knowledge sharing within and among research units. This paper focuses on a pilot study being conducted at a Japanese public graduate university – JAIST – under a Center of Excellence (COE) program that was established to bring the performance of research laboratories up to a world class level in productivity by applying the theories and tools of knowledge science. This study is a cooperative effort between the School of Knowledge Science, doing research on knowledge management and systems, and two research laboratories in the School of Materials Science, doing basic and applied research on materials science. The goal of this project is to enhance materials science students’ capabilities so that they become successful creators of new scientific knowledge. A group of seven graduate research students volunteered for the study. As one of the first steps, we introduced a formal and periodic written reporting system that motivates students to think strategically about their experiments, helps them to improve their communications skills, and enables students to self-evaluate their skills and supervisors to evaluate the students’ skills as well as monitor their progress and developments in a formalized way. Since the project is relatively new, these preliminary results are associated with a generalized awareness and participation of the students in the project. However, we are expecting to obtain more concrete results, that is, quantifiable improvements in scientific production, in the near future. 相似文献
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