Simultaneous changes in seed size,oil content and protein content driven by selection of SWEET homologues during soybean domestication     

Shoudong Wang  Shulin Liu  Jie Wang  Kengo Yokosho  Bin Zhou  Ya-Chi Yu  Zhi Liu  Wolf B Frommer  Jian Feng Ma  Li-Qing Chen  Yuefeng Guan  Huixia Shou  Zhixi Tian 《国家科学评论(英文版)》2020,7(11):1776

Soybean accounts for more than half of the global production of oilseed and more than a quarter of the protein used globally for human food and animal feed. Soybean domestication involved parallel increases in seed size and oil content, and a concomitant decrease in protein content. However, science has not yet discovered whether these effects were due to selective pressure on a single gene or multiple genes. Here, re-sequencing data from >800 genotypes revealed a strong selection during soybean domestication on GmSWEET10a. The selection of GmSWEET10a conferred simultaneous increases in soybean-seed size and oil content as well as a reduction in the protein content. The result was validated using both near-isogenic lines carrying substitution of haplotype chromosomal segments and transgenic soybeans. Moreover, GmSWEET10b was found to be functionally redundant with its homologue GmSWEET10a and to be undergoing selection in current breeding, leading the the elite allele GmSWEET10b, a potential target for present-day soybean breeding. Both GmSWEET10a and GmSWEET10b were shown to transport sucrose and hexose, contributing to sugar allocation from seed coat to embryo, which consequently determines oil and protein contents and seed size in soybean. We conclude that past selection of optimal GmSWEET10a alleles drove the initial domestication of multiple soybean-seed traits and that targeted selection of the elite allele GmSWEET10b may further improve the yield and seed quality of modern soybean cultivars.  相似文献   

Household Socioeconomic Status and Parental Investments: Direct and Indirect Relations With School Readiness in Ghana     

Sharon Wolf  Dana Charles McCoy 《Child development》2019,90(1):260-278

This study examines how parent socioeconomic status (SES) directly and indirectly predicts children's school readiness through pathways of parental investment. Data come from direct assessments with preschool children and surveys with their primary caregivers in Ghana at the start of the 2015–2016 school year (N = 2,137; M_age = 5.2 years). Results revealed SES-related gaps in all parental investment characteristics and child school readiness skills. Preschool involvement served as the primary mediating mechanism in the path from SES to most school readiness skills, though it did not predict executive function. The number of books in the household was marginally positively predictive of early literacy, whereas at-home stimulation was negatively related to motor, literacy, and numeracy skills.  相似文献   

Relationships between perceived attributes of innovations and their subsequent adoption     

Glenn S. Allan  W. C. Wolf Jr. 《Peabody Journal of Education》2013,88(4):332-336

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Editorial     

Teresa Cremin  Barbara Comber  Shelby Wolf 《Literacy》2007,41(2):55-61

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Eine Methode zur Konstruktion robuster Klassenhierarchien     

Arne Frick  Rainer Neumann und Wolf Zimmermann 《Informatik - Forschung und Entwicklung》1997,12(4):186-195

Zusammenfassung. In diesem Beitrag wird eine Methode zur Konstruktion robuster Klassenhierarchien vorgestellt. Hierzu wird aus den überlegungen bezüglich der polymorphen Verwendung von Klassen [2] eine Vorgehensweise zur Konstruktion von Klassenhierarchien abgeleitet. Die Begriffe Konformit?t und Spezialisierung werden verfeinert, indem nicht mehr s?mtliche Methoden einer Klasse, sondern Teilmengen davon betrachtet werden. Dies führt zum Begriff der partiellen Konformit?t. In Erweiterung von [2] sind partiell konforme Klassen dann polymorph verwendbar, wenn der Anwendungskontext, der sich aus der Benutzung der Klasse ergibt, sich ausschlie?lich auf konforme Methoden erstreckt. Diese Eigenschaft ist statisch zur übersetzungszeit überprüfbar. Damit k?nnen Fehlbenutzungen bereits zur übersetzungszeit ausgeschlossen werden. Eingegangen am 24. Dezember 1996 / Angenommen am 15. Oktober 1997  相似文献   

Computers: An introduction     

Richard Wolf 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1968,14(2):134-140

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Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes     

A. Zaher  S. Li  K. T. Wolf  F. N. Pirmoradi  O. Yassine  L. Lin  N. M. Khashab  J. Kosel 《Biomicrofluidics》2015,9(5)

Implantable drug delivery systems can provide long-term reliability, controllability, and biocompatibility, and have been used in many applications, including cancer pain and non-malignant pain treatment. However, many of the available systems are limited to zero-order, inconsistent, or single burst event drug release. To address these limitations, we demonstrate prototypes of a remotely operated drug delivery device that offers controllability of drug release profiles, using osmotic pumping as a pressure source and magnetically triggered membranes as switchable on-demand valves. The membranes are made of either ethyl cellulose, or the proposed stronger cellulose acetate polymer, mixed with thermosensitive poly(N-isopropylacrylamide) hydrogel and superparamagnetic iron oxide particles. The prototype devices'' drug diffusion rates are on the order of 0.5–2 μg/h for higher release rate designs, and 12–40 ng/h for lower release rates, with maximum release ratios of 4.2 and 3.2, respectively. The devices exhibit increased drug delivery rates with higher osmotic pumping rates or with magnetically increased membrane porosity. Furthermore, by vapor deposition of a cyanoacrylate layer, a drastic reduction of the drug delivery rate from micrograms down to tens of nanograms per hour is achieved. By utilizing magnetic membranes as the valve-control mechanism, triggered remotely by means of induction heating, the demonstrated drug delivery devices benefit from having the power source external to the system, eliminating the need for a battery. These designs multiply the potential approaches towards increasing the on-demand controllability and customizability of drug delivery profiles in the expanding field of implantable drug delivery systems, with the future possibility of remotely controlling the pressure source.  相似文献   

Exploring the experiences and responses of LGBTQ+ adolescents to school-based sexuality education     

Shereen C. Naser  Katherine Clonan-Roy  Kimberly A. Fuller  Elizabeth A. Goncy  Nicole Wolf 《Psychology in the schools》2022,59(1):34-50

The purpose of this study is to describe the experiences of lesbian, gay, bisexual, transgender, questioning, intersex, two spirit, and queer (LGBTQ+) youth with school-based sexuality education (SBSE), as well as to document strategies LGBTQ+ youth are using to address their evolving and specific sexual health needs outside of SBSE. Researchers conducted focus groups with 17 adolescents (ages 14–18) from urban and suburban Midwestern cities. Results of this study indicate LGBTQ+ youth find SBSE to be heteronormative, cisgender focused, and primarily focused on pregnancy and disease prevention, which contributes to LGBTQ+ youth experiences of exclusion. In response to SBSE that did not meet student needs, participants reported seeking sexual health information outside of SBSE. Other sources included family and other trusted adults, the Internet, and community resource centers. Students reported variable rates of use and trustworthiness across these resources. Results of this study suggest that school personnel should consider alternatives to traditional SBSE models to meet the needs of LGBTQ+ youth, and that an important part of SBSE should include guidelines for Internet safety.  相似文献   

Neurocognitive predictors of reading outcomes for children with reading disabilities     

Frijters JC  Lovett MW  Steinbach KA  Wolf M  Sevcik RA  Morris RD 《Journal of learning disabilities》2011,44(2):150-166

This study reports on several specific neurocognitive process predictors of reading outcomes for a sample of 278 children with reading disabilities. Three categories of response (i.e., poor, average, and good) were formed via growth curve models of six reading outcomes. Two nested discriminant function analyses were conducted to evaluate the predictive capability of the following models: (a) an intervention and phonological processing model that included intervention group, phonological awareness, and rapid naming and (b) an additive cognitive neuropsychological model that included measures of memory, visual processes, and cognitive or intellectual functioning. Over and above the substantial explanatory power of the base model, the additive model improved classification of poor and good responders. Several of the cognitive and neuropsychological variables predicted degree of reading outcomes, even after controlling for type of intervention, phonological awareness, and rapid naming.  相似文献   

Sprachförderung von Kindern und Jugendlichen aus Zuwandererfamilien     

Jennifer Paetsch  Katrin M. Wolf  Petra Stanat  Annkathrin Darsow 《Zeitschrift für Erziehungswissenschaft》2014,17(2):315-347

Children and adolescents of families with immigrant background are less successful in the German education systems than those without immigrant background. These differences can largely be explained by deficits in the language of instruction, indicating a lack of learning opportunities in the second language. The present paper investigates how it is possible to reduce language disparities before children enter school on the one hand and during the course of schooling on the other hand. This is being done by presenting the current state of research on the acquisition of a second language. In particular, recent findings on the influence of the quantity and quality of early childhood education on the language acquisition of children are summarized. Furthermore, findings on the effectiveness of attending all-day schools and of current programs for language instruction are presented. Finally, potential avenues for further development of language instruction as well as for future research are discussed.  相似文献