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Editor's note: The Association for College and Research Libraries (ACRL) made the following research agenda available in the February 2003 issue of College & Research Libraries News (Vol. 64, No. 2, pp. 108–113; reprinted with permission). Although this agenda has already been published, we believe it still merits reprinting, especially within the pages of an internationally focused research journal. The questions raised in ACRL's agenda indeed do deserve investigation, and the results of those investigations should appear in the scholarly literature. We encourage anyone who addresses those questions to first examine Developing Research & Communication Skills: Guidelines for Information Literacy in the Curriculum (Philadelphia, PA: Middle States Commission on Higher Education, 2003). This important report links information literacy with assessment and demonstrates the importance of that topic to an educational accreditation body. Furthermore, that linkage adds to (and rounds out) the research agenda. Clearly, information literacy as defined in that report is a topic of interest to anyone in education—higher education or other. 相似文献
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Ekaidem IS Bolarin DM Udoh AE Etuk SJ Udiong CE 《Indian journal of clinical biochemistry : IJCB》2011,26(2):187-192
Plasma fibronectin (FN) levels in obese/overweight and non-obese pregnant women were evaluated as a possible risk factor for
preeclampsia. A total of one hundred and sixty three pregnant women attending antenatal clinic at University of Calabar Teaching
Hospital participated in the study and sixty non-pregnant women served as control. About 77 (47.24%) of the pregnant women
were followed up for any subsequent development of preeclampsia during the pregnancy. Fibronectin levels in plasma were measured
by ELISA assay and serum total protein, urea and creatinine were determined spectrophotometrically. The mean plasma FN concentration
of non-obese pregnant women in first trimester was lower than those of the non-pregnant women by 24%, but however, increased
to the non-pregnant level in second and third trimesters. Obese/overweight pregnant women had significantly (P < 0.05) higher values than non-obese pregnant women in second and third trimesters. FN in obese/overweight pregnant women
correlated positively with mean arterial blood pressure (MAP: r = 0.414, P = 0.04). About 28.57% of the pregnant women with FN above cut off point of 330 μg/ml at 18–24 weeks of gestation developed
preeclampsia. This value increased to 40.0% when only the obese/overweight women were considered. On analysis of both fibronectin
>330 μg/ml and MAP > 90, the predictive value increased to 66.7%. We therefore conclude that elevated FN may be regarded as
a risk factor of preeclampsia especially among the obese women. 相似文献
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Itemobong S. Ekaidem Monday I. Akpanabiatu Friday E. Uboh Offiong U. Eka 《Indian journal of clinical biochemistry : IJCB》2007,22(2):36-40
Folic acid and vitamin B12 are very important vitamins needed for normal cellular metabolic activities. The effects of folic acid and vitamin B12 on liver integrity of growing Wistar albino rats following therapeutic dose of phenytoin administration were investigated.
The activities of serum AST, ALT, ALP were investigated. Serum total protein level and lipid profile were also measured as
indices of biochemical changes. The ingestion of phenytoin alone in rats significantly reduced serum protein while AST, ALT
activities incresed as compared to the control (P<0.05). Supplementation of phenytoin with oral administration of 70microgram/kg
body wt of folic acid resulted in a significant reversal in serum total protein and suppression in serum AST and ALT activities.
Vitamin B12 supplementation did not afford any significant protection against the effect of phenytoin ingestion but rather phenytoin
toxicity was exacerbated in this study. However, the combined effects of vitamin B12 and folic acid ameliorated the effects of phenytoin on serum enzymes of experimental rats. The effect of combination of phenytoin
with folic acid or folic acid and vitamin B12 is an interesting finding. Supplementation of phenytoin with folic acid or combination of these vitamins may be recommended
for the purpose of ameliorating the adverse biochemical changes which are associated with phenytoin therapy. Further work
is ongoing to help elucidate the effects of phenytoin and these vitamins on oxidative stress inducing mechanism. 相似文献
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Anthony J. Usoro Aniebietabasi S. Obot Itemobong S. Ekaidem Okon E. Akaiso Alphonsus E. Udoh O. Akinloye 《Indian journal of clinical biochemistry : IJCB》2015,30(1):59-65
Prostate carcinoma is the most frequently diagnosed malignancy and the second leading cause of death as a result of cancer in men in the US and other parts of the world. There are conflicting reports on the serum levels of testosterone and 17β-estradiol (E2) in benign prostatic hyperplasia (BPH) and prostate cancer. This study was designed to evaluate the serum concentrations of these hormones in patients with these disorders. Serum levels of prostate specific antigen (PSA), total testosterone and estradiol were determined in 228 subjects comprising of 116 subjects with BPH, 62 subjects with prostate cancer (CaP) and 50 age-matched apparently healthy controls, using ELISA methods. PSA levels were significantly elevated (p < 0.05) in BPH subjects than controls, while there was no significant difference (p > 0.05) in testosterone and estradiol levels of these subjects. PSA and estradiol levels were significantly higher (p < 0.05) in CaP subjects than in controls, while there was no observed significant difference (p > 0.05) in testosterone levels. CaP subjects had significantly raised PSA, testosterone, and estradiol levels than BPH subjects. The mean molar ratio of testosterone: E2 was lowest among CaP patients (134:1) and highest among controls (166:1). Significant positive correlation between PSA and 17β-estradiol was observed in prostate disorders (BPH and CaP patients: r = 0.347; p = 0.000). Significant negative correlations between testosterone and PSA were also observed among BPH patients (r = −0.221, p = 0.049) and control subjects (r = −0.490, p = 0.000). No significant correlation existed between testosterone and PSA in CaP patients (r = 0.051, p = 0.693). Correlations between age and estradiol in both BPH and CaP were not significant (p > 0.05). This study has shown that, there was a significant increase in serum estradiol in CaP subjects, while the testosterone levels in both BPH and CaP subjects were not different from those of controls. 相似文献
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