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Seitaro Kumamoto Kenshiro Nakatake Souichiro Fukuyama Keiichiro Yasuda Yusuke Kitamura Masaaki Iwatsuki Hideo Baba Toshihiro Ihara Yoshitaka Nakanishi Yuta Nakashima 《Biomicrofluidics》2020,14(6)
To study an environmental or biological solution, it is essential to separate its constituents. In this study, a 3D-deformable dynamic microfilter was developed to selectively separate the target substance from a solution. This microfilter is a fine metallic nickel structure fabricated using photolithography and electroplating techniques. It is gold-coated across its entire surface with multiple slits of 10–20 μm in width. Its two-dimensional shape is deformed into a three-dimensional shape when used for fluid separation due to hydrodynamic forces. By adjusting the pressure applied to the microfilter, the size of the gap created by deformation can be changed. To effectively isolate the target substance, the relationship between the solution flow rate and the extent of microfilter deformation was investigated. The filtration experiments demonstrated the microfilter’s ability to isolate the target substance with elastic deformation without undergoing plastic deformation. Additionally, modification of the microfilter surface with nucleic acid aptamers resulted in the selective isolation of the target cell, which further demonstrates the potential application of microfilters in the isolation of specific components of heterogeneous solutions. 相似文献
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The aim of this study was to determine the variations in substrate utilization between men and women matched for ventilatory threshold (Tvent) during incremental arm cranking and leg cycling exercise at 70, 85, 100 and 115% of the mode-specific Tvent. Recreationally active men (n=12) and women (n=10) with similar values for percentage of peak oxygen consumption at Tvent participated in the study. Ventilatory equivalence, excess CO2 and modified V-slope methods were used concurrently to determine Tvent. The participants performed 5 min of exercise at each of 70, 85, 100 and 115% Tvent during both arm cranking and leg cycling exercise. The females were tested during the early follicular phase for all trials. A two-way mixed-design analysis of variance was performed to test for differences between the sexes. When carbohydrate and fat oxidation were expressed relative to total fat-free mass, carbohydrate oxidation during arm cranking and leg cycling was significantly higher in men than women at each percentage of Tvent. In contrast, women showed significantly higher fat oxidation across intensities during both arm cranking and leg cycling. Our results suggest that when substrate utilization is expressed relative to total fat-free mass, women appear to maintain a higher rate of fat and lower rate of carbohydrate oxidation than men during both incremental arm cranking and leg cycling exercise relative to Tvent. 相似文献
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Tsutomu Hirao Manabu Okumura Norihito Yasuda Hideki Isozaki 《Information processing & management》2007,43(6):1521
The high quality evaluation of generated summaries is needed if we are to improve automatic summarization systems. Although human evaluation provides better results than automatic evaluation methods, its cost is huge and it is difficult to reproduce the results. Therefore, we need an automatic method that simulates human evaluation if we are to improve our summarization system efficiently. Although automatic evaluation methods have been proposed, they are unreliable when used for individual summaries. To solve this problem, we propose a supervised automatic evaluation method based on a new regression model called the voted regression model (VRM). VRM has two characteristics: (1) model selection based on ‘corrected AIC’ to avoid multicollinearity, (2) voting by the selected models to alleviate the problem of overfitting. Evaluation results obtained for TSC3 and DUC2004 show that our method achieved error reductions of about 17–51% compared with conventional automatic evaluation methods. Moreover, our method obtained the highest correlation coefficients in several different experiments. 相似文献
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Yoshihisa Hirakawa Mayu Yasuda Uemura Chifa Chiang Atsuko Aoyama 《Educational gerontology》2018,44(4):211-219
The purpose of this study is twofold: to assess the acceptance and usefulness of Nagoya University Small Private Online Courses, which is an online end-of-life care educational program through popular social media designed to supplement traditional end-of-life care education among healthcare professionals and to get constructive feedback with the aim of enhancing the impact of the program on fundamental knowledge of and attitudes toward end-of-life care provision. All 107 participants nationwide enrolled in this educational program completed the entire study. We found evidence of the beneficial effect of the social media strategies on participants’ knowledge and practice toward end-of-life care. In addition, data analyses provided insights into modifiable factors associated with learners’ active participation. 相似文献
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Abstract The aim of this study was to determine the variations in substrate utilization between men and women matched for ventilatory threshold (T vent) during incremental arm cranking and leg cycling exercise at 70, 85, 100 and 115% of the mode-specific T vent. Recreationally active men (n = 12) and women (n = 10) with similar values for percentage of peak oxygen consumption at T vent participated in the study. Ventilatory equivalence, excess CO2 and modified V-slope methods were used concurrently to determine T vent. The participants performed 5 min of exercise at each of 70, 85, 100 and 115% T vent during both arm cranking and leg cycling exercise. The females were tested during the early follicular phase for all trials. A two-way mixed-design analysis of variance was performed to test for differences between the sexes. When carbohydrate and fat oxidation were expressed relative to total fat-free mass, carbohydrate oxidation during arm cranking and leg cycling was significantly higher in men than women at each percentage of T vent. In contrast, women showed significantly higher fat oxidation across intensities during both arm cranking and leg cycling. Our results suggest that when substrate utilization is expressed relative to total fat-free mass, women appear to maintain a higher rate of fat and lower rate of carbohydrate oxidation than men during both incremental arm cranking and leg cycling exercise relative to T vent. 相似文献
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