Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels     

Michael Sponder  Ioana-Alexandra Campean  Michael Emich  Monika Fritzer-Szekeres  Brigitte Litschauer  Jutta Bergler-Klein 《Journal of sports sciences》2017,35(21):2129-2134

Cathepsin S (CS) was shown to play a key role in cancer progression, atherosclerosis, heart valve disease, insulin resistance and diabetes mellitus. The present prospective study aimed to investigate the influence of sports on CS, interleukin-6 (Il-6) and high-sensitivity C-reactive protein (hsCRP) levels.

Ninety-eight of 109 participants completed the study. Ergometries were performed at baseline and after 8 months to evaluate/quantify the performance gain. Blood samples were taken at baseline and every 2 months. CS was measured by ELISA (enzyme-linked immunosorbent assay). Compared to the control group (mean performance gain ?3.41 ± 4.62%) we observed a significant physical-activity-induced increase of CS levels (3.45–3.73 ng · ml^?1; P = 0.027) and a significant decrease of Il-6 (2.43–1.91 pg · ml^?1; P = 0.031) and hsCRP-levels (0.11–0.09 mg · dl^?1; P = 0.001) in the intervention group (mean performance gain: 12.13 ± 6.32%). Furthermore, the tendency of the progression was significant for CS and Il-6 (P = 0.002/0.033).

We could show a significant sports-induced decrease of the classic inflammation parameters hsCRP/Il-6, probably expressing a downregulation of permanently prevalent inflammation processes. Simultaneously CS levels increased significantly. Our results show that increasing CS amounts are not simply to equal with an enhanced inflammation status and might even have beneficial effects on inflammation and angiogenesis.  相似文献   

Three dimensional couette flow and heat transfer through a porous medium with variable permeability     

Chaudhary?R.?C.?Email author  Sharma?Pawan?Kumar 《浙江大学学报(A卷英文版)》2003,4(2):181-185

This paper reports research on the effects of variations in injection velocity and permeability on the heat transfer and flow through a highly porous medium between two horizontal parallel plates situated at constant distance with constant suction by the upper plate. Due to this type of variation in injection velocity and in permeability the flow becomes three dimensional. The governing equations are solved by adopting complex variable notations to obtain the expressions for the velocity and temperature field. The skin-friction along the main flow direction and rate of heat transfer are discussed with the help of graphs.  相似文献   

Teacher Empathy and Attitudes Towards Individuals with Disabilities     

Monika Parchomiuk 《International Journal of Disability, Development & Education》2019,66(1):56-69

The article presents research results of a study aimed at determining the correlation between empathy understood as a personality disposition and general attitudes towards individuals with disability. The sample consisted of 300 special education teachers working with persons with intellectual disabilities in primary and secondary schools and institutions of rehabilitation, and 280 general education teachers working with able-bodied students in primary and secondary schools. Two instruments were used: Empathic Understanding of Other People Questionnaire, and the Scale of Attitudes towards Individuals with Disability. In the group of special education teachers, only Syndrome 2 of empathy was statistically significant for shaping the attitudes, whereas among teachers, Syndromes 1, 3 and 4 were significant. In Syndromes 1, 2 and 4, including the highest level of emotional, cognitive, motivational and communication aspects of empathy, the correlations were positive as expected. In the case of Syndrome 3, including the considerable level of cognitive empathy, the correlation was negative.  相似文献   

WOMEN IN DISTANCE STUDY ‐ WOMEN STUDENTS AT THE FERNUNIVERSITAT IN HAGEN (FEDERAL REPUBLIC OF GERMANY)     

Michaele Hetzel  Monika Schneidereit  Angela Schuch 《Higher Education in Europe》1981,6(3):18-22

The authors take up the hypothesis that distance education was also meant to facilitate the access of women to higher education. Recent studies carried out at the University for Distance Education at Hagen show that results do not always match expectations. By analysing in detail the causes for this partial failure, the authors come forward with some remedial proposals.

The authors are all members of the staff of Hagen University.  相似文献   

Effect of Tara (Caesalpinia spinosa) Pod Powder on the Oxidation and Colour Stability of Pork Meat Batter During Chilled Storage     

Monika Skowyra  Urszula Janiewicz  Anna Marietta Salejda  Gra?yna Krasnowska  María Pilar Almajano 《Food Technology and Biotechnology》2015,53(4):419-427

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A study of usage of symbols and opinionated words in annotation for modeling literature survey experiences     

Archana Shukla  Banshi D. Chaudhary 《Education and Information Technologies》2015,20(1):91-111

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Perspective Paper: Assessing Air Quality as Part of a Physical Therapy Plan of Care     

Dennis C. Sobush  Monika Burrescia 《Cardiopulmonary Physical Therapy Journal》2011,22(1):20-24

Purpose: The purposes of this clinical perspective paper are (1) to expand physical therapists’ awareness to the topic of air quality as a health priority when providing professional services; and (2) to provide templates for screening the indoor clinical environments and patient profiles to avert respiratory exacerbations, especially in persons with asthma. Summary of Key Points: The location where a physical therapist practices determines the air quality indices to which a person is exposed. Poor indoor air quality can expose a person to even greater compromise of respiration (ie, Sick Building Syndrome) than outdoor air quality secondary to an array of factors like building materials, the ventilation exchange rate of an enclosed space, chemicals used in cleaning, and humidity. Statement of Conclusions: Extrinsic (ie, environmental) and intrinsic (eg, pre-disposition to airway hypersensitivity) factors must be accounted for by physical therapists to safeguard their patients and themselves from experiencing respiratory compromise and/or distress as a result of a treatment session or their place of employment. Recommendations: Efforts to screen indoor environments for potential triggers and patient risk profiles for abnormal airway reactivity should routinely be undertaken. Individualized Action Plans should be prospectively prepared and readied for implementation when warranted.Key Words: asthma, Sick Building Syndrome, indoor air quality, respiratory impairment  相似文献   

A strategy for detection of inconsistency in evaluation of essay type answers     

Archana Shukla  Banshi D. Chaudhary 《Education and Information Technologies》2014,19(4):899-912

The quality of evaluation of essay type answer books involving multiple evaluators for courses with large number of enrollments is likely to be affected due to heterogeneity in experience, expertise and maturity of evaluators. In this paper, we present a strategy to detect anomalies in evaluation of essay type answers by multiple evaluators based on the relationship between marks/grades awarded and symbolic markers, opinionated words recorded in answer books during evaluation. Our strategy is based on the results of our survey with evaluators, analysis of large number of essay type evaluated answer books and our own experiences regarding grievances of students regarding marks/grades. Results of both survey and analysis of evaluated answer books identified underline, tick and cross as frequently used markers compared to circle and question mark. Further, both opinionated words and symbolic markers identified through the survey are used by evaluators to express either positive or negative sentiments. They have differential usage pattern of these symbols as single evaluator and as one amongst multiple evaluators. Tick and cross have well define purposes and have strong correlation with marks awarded. However, the underline marker is being used for dual purpose of expressing both correctness and incorrectness of answers. Our strategy of inconsistency detection first identifies outliers based on the relationship between marks/grades awarded and number of symbols and/or opinionated words used in evaluation. Subsequently, marks and number of symbolic markers of outliers are compared with peer non-outlier answer books having same marks but different number of markers used. Such outlier answer books are termed as anomalous. We discovered 36 anomalies out of total 425 evaluated answer books. We have developed a prototype tool to facilitate online evaluation of answer book and to proactively alert evaluators of possible anomalies.  相似文献   

Pathways From Childhood Sociomoral Sensitivity in Friendship,Insecurity, and Peer Rejection to Adult Friendship Quality     

Annekatrin Steinhoff  Monika Keller 《Child development》2020,91(5):e1012-e1029

Across the life span, friendship is an important component of people’s support networks. This article explores the developmental roots of adult friendship intimacy and satisfaction, taking into consideration the early interplay between sociomoral sensitivity in friendship, insecurity in peer contexts, and peer rejection. Data (N = 176) came from the longitudinal study “Individual Development and Social Structure.” Respondents were surveyed repeatedly from age 7 to 37 years. Autoregressive cross-lagged panel models show that sociomoral sensitivity in friendship protects adolescents from peer rejection and is reciprocally associated with insecurity. Childhood and adolescent sociomoral sensitivity antecede early adult friendship intimacy, which, in turn, antecedes friendship satisfaction in mid-adulthood. The findings indicate a sequence of pathways from sociomoral sensitivity developed early in life to friendship quality in adulthood.  相似文献   

Block scheduled versus traditional biology teaching—an educational experiment using the water lily     

Christoph Randler  Konstanze Kranich  Monika Eisele 《Instructional Science》2008,36(1):17-25

In this study, we compared a traditional teaching sequence (four distinct lessons) with a block schedule dealing with the ecological adaptations of the water lily. The educational unit contained original plant material and both experimental groups received the same tasks and working sheets. Pupils worked together in groups of three to four pupils in a self-regulated manner, carrying out hands-on experiments. However, both groups differed in their time schedule (four distinct lessons of 45 min versus one block of 180 min). Pupils from the traditionally scheduled education performed significantly better in the immediate post-test while these differences merged in retention.  相似文献