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1.
K. Poornima M. Cariappa K. Asha H. P. Kedilaya M. Nandini 《Indian journal of clinical biochemistry : IJCB》2003,18(2):197-205
An adequate antioxidant reserve which is usually present in a vegetarian diet is associated with higher life expectancy. On
the other hand habitual consumption of fish is associated with lower risk of cardiovascular diseases which is attributed to
the polyunsaturated fatty acids (PUFA) present in it. However the PUFA are readily susceptible to oxidation leading to the
formation of free radicals which is known to be involved in the causation of several diseases.
The oxidant-antioxidant status of 23 vegetarians and 22 fish eaters was studied by determining the plasma lipid peroxides
measured as malondialdehyde (MDA) and the antioxidants, viz. glutathione (GSH), ascorbic acid, ceruloplasmin and uric acid.
Results show that the ascorbic acid values were significantly higher in vegetarians. In addition, MDA correlated negatively
with ascorbic acid only in vegetarians. However, correlation of MDA with glutathione showed a significant negative correlation
only in fish eaters. There was no statistically significant difference in the MDA, GSH, ceruloplasmin and uric acid levels.
The mechanism behind these findings are not clear and needs to be explored. 相似文献
2.
Afzal Ahmad Rukmini Mysore Srikantiah Charu Yadav Ashish Agarwal Poornima Ajay Manjrekar Anupama Hegde 《Indian journal of clinical biochemistry : IJCB》2016,31(4):458-462
The cause of more insulin resistance in female than males are still unknown. To know the cause from early life, normal values of relevant parameters are required. So, aim of this study was to determine the reference levels of glucose and insulin in cord blood of term newborns and to examine their effects on gender, placental and birth weight of term newborns. In cross sectional study 60 consecutive term newborns were included from constituent hospitals. Placental and birth weights were measured and cord blood was collected for estimation of serum insulin and plasma glucose. Plasma glucose estimation was done by auto analyzer (GOD–POD method) and serum insulin analysis was done using Insulin ELISA Kit. After analysis, mean ± 2SD used for estimating cord blood insulin and glucose levels, which were 10.1 ± 7.8 μIU/mL and 67.8 ± 33.8 mg/dL respectively. Correlation of insulin with both birth weight and placental weight were r = 0.359 and 0.41 respectively; p < 0.001. Interestingly we found higher insulin levels in females as compared to male newborns in spite of having lower birth weight in them. In conclusion this study reported the levels of insulin and glucose in cord blood of term newborns. Incidentally, this is the first study as per our knowledge to report significant correlation between cord blood insulin, glucose with birth weight, placental weight and gender in south India. Female newborns had higher insulin levels than males, despite lesser birth weight can be attributed to intrinsic insulin resistance in them. 相似文献
3.
Diabetics showed significantly raised levels of total and LDL cholesterol, (257.0±68.88 mg% 173.5±67.7mg% respectively) compared
to controls matched with age, sex and socioeconomic status. No significant difference was observed in these parameters in
diabetics with and without retinopathy. 相似文献
4.
Vashist SK Kaur I Bajpai RP Bharadwaj LM Tewari R Raiteri R 《Journal of Zhejiang University. Science. B》2006,7(9):683-685
We report an important observation that the surface conductivity of antibody layer immobilized on polylysine-coated glass
substrate decreases upon the formation of complex with their specific antigens. This change in conductivity has been observed
for both monoclonal and polyclonal antibodies. The conductance of monoclonal mouse IgG immobilized on polylysine-coated glass
substrate changed from 1.02×10−8 Ω−1 to 1.41×10−11 Ω−1 at 10 V when complex is formed due to the specific biomolecular interactions with rabbit anti-mouse IgG F(ab′)2. Similar behavior was observed when the same set up was tested in two clinical assays: (1) anti-Leishmania antigen polyclonal
antibodies taken from Kala Azar positive patient serum interacting with Leishmania promastigote antigen, and (2) anti-p21
polyclonal antibodies interacting with p21 antigen. The proposed concept can represent a new immunodiagnostic technique and
may have wide ranging applications in biosensors and nanobiotechnology too. 相似文献
5.
M. Cariappa K. Poornima M. Nandini K. Asha H. P. Kedilaya 《Indian journal of clinical biochemistry : IJCB》2005,20(1):103-108
Habitual consumption of moderate amounts of fish is associated with reduced mortality from coronary heart disease. However
the beneficial effects of fish enriched diet seem contradictory, due to the susceptibility of the PUFAs in them to oxidation.
It is also acclaimed that vegetarians in general, have a lower serum total cholesterol and LDL-cholesterol and a better antioxidant
status. This contradiction was the basis for the study, where the validity of the above finding was tested in a general population
consuming a vegetarian or predominantly fish diet as a regular dietary habit. The oxidant status and the lipid profile of
23 vegetarians and 22 fish eaters was studied by estimating the plasma lipid peroxides measured as malondialdehyde (MDA) and
the lipid parameters viz. Total Cholesterol (TC), HDL-Cholesterol (HDL-C) and triglycerides (TG). Statistical analysis was
carried out to compare the MDA values and the lipemic status between the two groups. MDA was also correlated with the various
lipid indices among the study groups. None of the compared and correlated values was statistically significant, although certain
altered trends were seen. From this study, it may be concluded that oxidant status and lipid profile does not vary significantly
in the two groups, suggesting that neither a vegetarian diet nor a fish diet has a definite benefit over the other. 相似文献
6.
Of late blended learning is a popular choice of training in India. To assess the effectiveness of Human Compute Interaction (HCI) in blended mode, evaluation by trainee group was undertaken. The trainees with a background in commerce evaluated the blended learning system using a Likert type evaluation form. Due to the non-parametrical nature of data, we adopt RIDIT method to analyze data. The novel approach in this paper is the use of RIDIT method to analyze qualitative HCI features quantitatively. The trainee feedback has provided an understanding of the extent to which blended learning is acceptable. The evaluation provides insight into level of preference given among human-human, human-computer and technology aspect by trainees. This evaluation looks promising and provides opportunity for further developments in blending HCI features into blended learning environment to provide worthwhile and relevant learning opportunities. 相似文献
7.
This mixed‐methods study probed the effectiveness of three kinds of objects (video, theory, metaphor) as common reference points for conversations between online learners (student teachers). Individuals’ degree of detail‐focus was examined as a potentially interacting covariate and the outcome measure was learners’ level of tacit knowledge related to their practice (teaching). Analysis was conducted using hierarchical linear modeling and significant results were followed up with a qualitative theme analysis. An interaction between reference point type and detail‐focus was found, demonstrating a positive effect of detail‐focus within the metaphor condition. Unexpectedly, some participants interpreted the metaphors in ways other than those intended, leading to differences in the kinds of understandings developed. The study indicated that a conceptual frame is an important characteristic of a reference point that will be truly taken in common, and that metaphors need additional framing to be viable in this role. Implications for online learning conversation design are discussed. 相似文献
8.
Arvind Kumar Poornima Tewari Sibasis S. Sahoo Arvind Kumar Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(2):10-17
A total of 172 first degree relatives (FDRs) and 178 controls were included in this study. All the cases and controls were
subjected to various anthropometric measurements, fasting and postprandial glucose estimation, fasting insulin measurement
and fasting lipid profile. Results revealed the prevalence of Impaired Fasting Glucose (IFG) (cases 37% Vs controls 11.6%),
Impaired Glucose Tolerance (IGT) (cases 34.3% Vs controls 11.2%) and diabetes (cases 11.05% controls 3.37%) was significantly
higher in first degree relatives. Insulin resistance was measured using various methods, which included fasting plasma insulin
(FPI), Homeostasis Model Assessment for Insulin Resistance (HOMAIR), insulin sensitivity index (ISI) (Mffm/l). Prevalence of insulin resistance (Insulin Resistance) as observed comparing FPI
and HOMAIR in cases and controls was 43.6% and 11.24% (P=0.005) and 37.8% and 12.47% (P=0.000) respectively. Prevalence of IR (Insulin
Resistance) observed in cases having Normal Glucose Tolerance (NGT), Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance
(IGT) and diabetes mellitus measuring FPI Vs HOMAIR was 37.5% vs 30.2%, 45% vs 40%, 38.98% vs 37.28% and 36.84% vs 31.57% as accordingly. However, ISI (Mffm/l) was not found
to be a promising index for IR due to its poor specificity. Though HOMA is taken as gold standard for measurement of IR globally,
our study observed fasting plasma insulin representing high sensitivity (89.7%) and specificity (93.3%) as compared to HOMA.
Thus FPI had emerged in this work as a simple and reliable test for diagnosing insulin resistance across the population susceptible
to develop diabetes including FDRs. 相似文献
9.
Pradeep Venkatesh Garg Satpal Lalit Verma Tewari Hem Kumar Sheena Garg 《Indian journal of clinical biochemistry : IJCB》2001,16(1):9-14
Antioxidants are a small group of substances that protect living cells from the destructive consequences of powerful oxidizing
intermediates that can be formed from oxygen. Situations in which pro-oxidant mechanisms within the body are more active than
the antioxidant mechanisms (oxidative stress) predispose and contribute to the pathogenesis of several ailments in various
organs of the body. In the eye, pro-oxidant factors have been blamed for the causation of diseases such as age related macular
degeneration and senile cataract. The role of pro-oxidants in the genesis of certain diseases is well established however,
the effectivity of antioxidants provided to the body by dietary supplementation is inconclusive. In this article we provide
a review on the basic concepts of antioxidant-pro-oxidant interaction in relation to its effects on the eye. 相似文献
10.
Poornima Padmanabhan 《Educational Media International》2013,50(2):81-95
Low-cost laptop programs attempt to address gaps in access to computers in developing countries. However, the translation of computing access from intention to actuality is mediated by many situational factors. This research presents a case study of how access to a set of laptops donated to a school for socially disadvantaged children in India was shaped by social, logistical, economic and value considerations. Findings illustrate how principles of equity driving the program clashed with limited resources to produce conditions that constrained student agency. Additionally, external dependencies for laptops, knowledge and support restricted the school’s ability to provide computing access, and set up uncomfortable internal inequalities within the school. Access increased for just one class of students, and even they only used the laptops for limited time periods, in pairs, and under direct supervision. Seven important access considerations related to equity, resources and agency are identified to support strategic planning of future laptop programs. 相似文献