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1.
Ramesh Chander Farhan Rizvi A. K Khanna Ram Pratap 《Indian journal of clinical biochemistry : IJCB》2003,18(2):71-79
Guggulsterone, a mixture of cis (E) and trans (Z) isomers (7∶3 w/w) was synthesized from 16-DPA. The isomers were separated
by column chromatography and evaluated for cardioprotective and antioxidant activities. Myocardial necrosis induced by isoproterenol
in rats caused marked increase in serum creatine phosphokinase and glutamate pyruvate transaminase. Simultaneously in ischemic
heart, phospholipase, xanthine oxidase and lipid peroxides were enhanced following depletion of glycogen, phospholipids and
cholesterol. Treatment with guggulsterone and its both isomers at the dose of 50 mg/kg po., significantly protected cardiac
damage as assessed by the reversal of blood and heart biochemical parameters in ischemic rats. The cardioprotective activity
of guggulsterone and of both the isomers were compared with that of gemfibrozil at the same doses. Guggulsterone and both
the isomers at tested concentrations (5–20mM) inhibited oxidative degradation of lipids in human low-density lipoprotein and
rat liver microsomes induced by metal ionsin vitro. The drug counteracted against the generation of superoxide anions (O2) and hydroxyl radicals (OH−) in non-enzymic test systems. It is suggested that cardioprotective and antioxidant activities of synthetic guggulsterone
and guggulsterone obtained from gum resinCommiphora mukul that contains isomers E & Z in the ratio of 46∶54w/w are the same. 相似文献
2.
Suresh Chander Jain Bandana Talukdar 《Indian journal of clinical biochemistry : IJCB》1995,10(2):62-65
The effect of 40 days yoga training in 30 hospitalized non-insulin dependent diabetes mellitus (NIDDM) patients has been investigated after stopping the medication. Blood glucose response to oral glucose load measured as area index total (AIT), glycated haemoglobin (GHb) plasma lipids and lipoproteins measurements before and after yoga training have been compared. Yoga training resulted in a significant improvement in AIT, GHb and plasma triglycerides and cholesterol levels. The data suggest that yoga training along with diet and medical management provides an important metabolic control in NIDDM and may have a role in primary prevention of diabetes mellitus. 相似文献
3.
Ramesh Chander A. K. Khanna Kanwal Raj A. K. Rastogi 《Indian journal of clinical biochemistry : IJCB》2005,20(1):153-159
Indian black tea; CTC leaf and dust, produced by Tata Tea Limited, Kolkata, (India) was studiedin vitro as potential scavenger of oxygen free radicals. Super oxide anions were generated in a system containing xanthine—xanthine
oxidase (enzymic system) and by NADH- phenozine methosulphate (non enzymic system). Anions were assayed in terms of uric acid
formation and reduction of nitroblue tetrazolium salt, which were shown to be suppressed by tea extracts. Extracts from both
leaf and dust also inhibted the formation of hydroxyl radicalsin vitro in the enzymic system comprising hypoxanthine—Cu+2—sodium ascorbate and xanthine oxidase and in non enzymic system of deoxyribose—Cu+2—sodium ascorbate and H2O2 as well as the Cu+2 induced lipid peroxidation in human low density lipoprotein. Feeding with black tea in normal rats for sixty days increased
their antioxidant activity and their liver microsomes were shown to be protected against peroxidation of lipids as stimulated
by metal ions with enzymic or non enzymic reactants. Furthermore feeding with tea extracts in normal as well as triton WR—1339
induced hyperlipidemic rats caused decrease in their plasma levels of total cholesterol, phospholipids and triglycerides.
The antioxidant and lipid lowering activities of both extracts from CTC leaf and dust tea was comparable and may be due to
the presence of natural products like catechin and others. 相似文献
4.
Jyothi M. P. D’souza Sindhu Harish Vinitha Ramanath Pai Chitra Shriyan 《Indian journal of clinical biochemistry : IJCB》2017,32(2):200-206
Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia. 相似文献
5.
Ishrat Husain Ramesh Chander Jitendra Kumar Saxena Abbas Ali Mahdi Farzana Mahdi 《Indian journal of clinical biochemistry : IJCB》2015,30(1):72-77
The antidyslipidemic activity of Ocimum sanctum leaf extract was studied in streptozotocin induced diabetic rats. In this model, there was significant increase in plasma markers of diabetic-dyslipidemia following diminution of lipid metabolizing enzymes. Oral administration of leaf extract (500 mg/kg b.w.p.o.) for 15 days resulted in significant decrease in diabetogenic and dyslipidemia parameters; namely blood glucose, glycosylated hemoglobin, lipid peroxide, free fatty acids, small dense low density lipoprotein, lipid and protein components of plasma lipoproteins, adipose and liver. The regulation of lipids was accompanied by stimulation of postheparin lipolytic activity, reactivation of lecithin cholesterol acyl transferase and hepatic lipoprotein lipase enzymes. The results of the present study demonstrated antidyslipidemic and antioxidant activities in leaf extract of O. sanctum which could be used in prevention of diabetic-dyslipidemia and related complications. 相似文献
6.
If we adopt the definition that an earthquake is shaking of the earth due to natural causes, then we may argue that earthquakes
have been occurring since the very beginning of the earth about 4.5 billion years ago. 相似文献
7.
Harish Kumar Argyro Elisavet Manoli Ian R. Hodgkinson Paul Downward 《Sport Management Review》2018,21(5):549-562
Sport delivery systems, aimed at facilitating sports participation, represent an inter-institutional, cross-sector collaboration. Researchers focusing on the impact of different levels of sport provision from policy, through facilities, to end users remains limited. The authors address this gap in knowledge through a mixed- methods approach to examine sport participation from the perspective of the whole delivery system. Specifically, focusing on a County Sport Partnership region in the UK, the authors examine sport participation from the policy (macro), facility (meso), and end user (micro) levels. Regional heads responsible for sport development and delivery participated in semi-structured interviews, facility-level managers completed a survey, and end-users across public, private, and outsourced facilities participated in focus groups. Results show a clear divergence between the sport policy goals across the private and public sectors, with significant differences observed between facility types on their social and commercial objectives and their prioritized stakeholder groups. The divergence has little impact on user participation or expression of health, wellbeing, and social capital, offering new evidence on the role of neoliberalism in sport delivery systems. 相似文献
8.
Can dams and reservoirs cause earthquakes? 总被引：1，自引：0，他引：1
Ramesh Chander 《Resonance》1999,4(11):4-13
No! Not on their own. But, stresses and pore pressure due to natural causes may already have accumulated in crustal rocks
at some dam sites to near critical levels for fresh faulting or renewed slip on nearby pre-existing faults. The stresses and
pore pressure induced by impoundment of reservoirs there may marginally abet the tendencies to such failures and even trigger
or induce earthquakes by being the proverbial last straw. 相似文献
9.
Ozge Ozberk Ramesh Chander Sharma Gokmen Dagli 《International Journal of Disability, Development & Education》2019,66(6):598-609
ABSTRACTThe aim of this study is to determine primary school administrators’ and teachers’ opinions about the quality of their schools; the school administrators and teachers’ knowledge about Total Quality Management and quality tools and the quality tools used in primary schools. The research has been carried out with a qualitative approach and it is in the case study pattern. The participants consisted of 16 teachers and 4 school administrators working in primary schools in North Cyprus. The participants were chosen via maximum sampling method. The findings show that the current situation in schools contradicts with the basic principles of Total Quality Management. It was determined that school administrators were ignorant about Total Quality Management and none of the teachers and school administrators had previously heard the concept of quality tools. Teachers and school administrators mentioned disabled students as an issue. It seems like teachers have problems in behaving in the right way towards these students. They do not know how to improve these students’ talents because they are not educated on the subject. Via tools of quality teachers and school administrators may find reasons and solutions for issues like people with disabilities and plan events to promote disability awareness. 相似文献
10.
Harish Karnick 《Resonance》2014,19(3):208-221
This article discusses the programming language LISP. The language was created by John McCarthy for an artificial intelligence application. LISP was the first functional language based on a mathematical theory of computation. It has been standardized and is still used fairly widely. The language also had a huge influence on later languages. Its implementation introduced interpreted languages, source-level debugging and garbage collection. These facilities are a common denominator for many languages today. We discuss the mathematical foundations of LISP the interpreter and briefly touch on its influence on other languages and its status today. 相似文献